Biomedical Applications of Proteomics

  • ID: 2183026
  • Book
  • 452 Pages
  • John Wiley and Sons Ltd
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The first book to provide an overview over applications of proteomics in the discovery of new diagnostic, prognostic and therapeutic targets. Examples of applications are presented for the most important diseases like heart and cardiovascular disorders, cancer, infectious diseases and diseases of the nervous system. Aspects of pharmatoxicology as well as bioinformatics are also included.

Authors form the U.S., Europe and Australia contribute with their specific expertise. They are professionals from research institutions, hospitals and companies.

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Preface

SECTION I: ASPECTS OF BIOMEDICAL RESEARCH

Proteomics in Biomedicine –

A Tool, a Science or an Art?

SECTION II: BLOOD VESSELS

Antibody–Based Vascular Targeting: Proteomic Techniques for the Identification and Quantitation of Membrane Proteins on Endothelial Cells

Vasculature, Vascular Disease and Atherosclerosis

Discovery of New Diagnostic Markers of Stroke

SECTION III: CANCER

Unravelling Biological Pathways and the Identification of Clinical Markers and Targets in Renal Cancer

HSP27 in Cancer

Proteomic Approaches for Biomarker Discovery in Colorectal Cancer

Clinical Proteomics: Ovarian Cancer

Protein Expression Profiling Analysis in Hematopoietic Stem Cells: Phenotypic Characterization of Mesenchymal Stem Cells

Lymphoblastoid and Lymphoma Cells

SECTION IV: PHARMACO–TOXICOLOGY

Chemoresistance in Cancer Cells

Diabetes Mellitus: Complex Molecular Alterations)

SECTION V: INFECTIOUS DISEASES

Proteome Approach to Infectious Diseases

New Insights Into HIV Lymphocyte Infection

Modifications of Host–Cell Proteomes Induced by Herpes Virus Type 1

Francisella Tularensis

SECTION VI: CENTRAL NERVOUS SYSTEM

Proteomics in Clinical Neurosciences

Human Cerebrospinal Fluid

Proteomic Applications for Molecular Assessment of Alzheimer′s Disease

SECTION VII: MASS SPECTROMETRY AND BIOINFORMATICS

MALDI MS Imaging in Biomedical Research

Protein Variations: Resources and Tools
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"In spite of the complexity of many diseases as well as proteomic approaches that may be applied, the style of the book is generally clear and straightforward in its presentation."

Proteomics

"This book is a good reference resource for all academic and other researchers who are interested in how proteomics is applied in biomedicine."

E–STREAMS

"... a nice overview of biomedical proteomics applications."

Clinical Chemistry

"...those new to the field can use the book to quickly catch up on applications of proteomics. ... the book [is also] a great resource for literature and techniques."

Environmental Health Perspectives

"...this book is a compendium of biomedical publications covering a wide range of state–of–the–art proteomic techniques and aimed to give a detailed view what current proteomic technologies can serve for in biomedical research. The clear style of the book and its straightforward presentations provides profound insight to scientists. Furthermore, it serves as a good resource for literature and techniques for academic and other researchers interested in the implementation of proteomics in biomedicine. (...) Overall the editors provide a comprehensive overview on biomedical proteomics applications for both, protein analysts familiar with state–of–the–art proteome technologies as well as physicians in molecular medicine."

Arneimittel–Forschung/Drug Research

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