Biomedical Applications of Proteomics

  • ID: 2183026
  • Book
  • 452 Pages
  • John Wiley and Sons Ltd
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The first book to provide an overview over applications of proteomics in the discovery of new diagnostic, prognostic and therapeutic targets. Examples of applications are presented for the most important diseases like heart and cardiovascular disorders, cancer, infectious diseases and diseases of the nervous system. Aspects of pharmatoxicology as well as bioinformatics are also included.

Authors form the U.S., Europe and Australia contribute with their specific expertise. They are professionals from research institutions, hospitals and companies.

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Preface

SECTION I: ASPECTS OF BIOMEDICAL RESEARCH

Proteomics in Biomedicine –

A Tool, a Science or an Art?

SECTION II: BLOOD VESSELS

Antibody–Based Vascular Targeting: Proteomic Techniques for the Identification and Quantitation of Membrane Proteins on Endothelial Cells

Vasculature, Vascular Disease and Atherosclerosis

Discovery of New Diagnostic Markers of Stroke

SECTION III: CANCER

Unravelling Biological Pathways and the Identification of Clinical Markers and Targets in Renal Cancer

HSP27 in Cancer

Proteomic Approaches for Biomarker Discovery in Colorectal Cancer

Clinical Proteomics: Ovarian Cancer

Protein Expression Profiling Analysis in Hematopoietic Stem Cells: Phenotypic Characterization of Mesenchymal Stem Cells

Lymphoblastoid and Lymphoma Cells

SECTION IV: PHARMACO–TOXICOLOGY

Chemoresistance in Cancer Cells

Diabetes Mellitus: Complex Molecular Alterations)

SECTION V: INFECTIOUS DISEASES

Proteome Approach to Infectious Diseases

New Insights Into HIV Lymphocyte Infection

Modifications of Host–Cell Proteomes Induced by Herpes Virus Type 1

Francisella Tularensis

SECTION VI: CENTRAL NERVOUS SYSTEM

Proteomics in Clinical Neurosciences

Human Cerebrospinal Fluid

Proteomic Applications for Molecular Assessment of Alzheimer′s Disease

SECTION VII: MASS SPECTROMETRY AND BIOINFORMATICS

MALDI MS Imaging in Biomedical Research

Protein Variations: Resources and Tools
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Jean–Charles Sanchez
Garry L. Corthals
Denis F. Hochstrasser
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