Aziridines and Epoxides in Organic Synthesis

  • ID: 2183054
  • Book
  • 516 Pages
  • John Wiley and Sons Ltd
1 of 4
Aziridines and epoxides are among the most widely used intermediates in organic synthesis, acting as precursors to complex molecules due to the strains incorporated in their skeletons. Besides their importance as reactive intermediates, many biologically active compounds also contain these three–membered rings.

Filling a gap in the literature, this clearly structured book presents the much needed information in a compact and concise way. The renowned editor has succeeded in gathering together excellent authors to cover synthesis, applications, and the biological aspects in equal depth.

Divided roughly equally between aziridines and epoxides, the twelve chapters discuss:

∗ Synthesis of aziridines

∗ Nucleophilic ring–opening of aziridines and epoxides

∗ Organic synthesis with aziridine building blocks

∗ Vinyl aziridines in organic synthesis

∗ Diastereoselective aziridination reagents

∗ Synthetic aspects of aziridinomitocene chemistry

∗ Biosynthesis of biologically important aziridines

∗ Organic catalysis of epoxide and aziridine ring formation

∗ Metal–mediated synthesis of epoxides

∗ Asymmetric epoxide ring opening chemistry

∗ Epoxides in complex molecule synthesis

∗ Biological activity of epoxide–containing molecules

A high–quality reference manual for academic and industrial chemists alike.

Note: Product cover images may vary from those shown
2 of 4
ASYMMETRIC SYNTHESIS OF EPOXIDES AND AZIRIDINES FROM ALDEHYDES AND IMINES

Asymmetric Epoxidation of Carbonyl Compounds

Asymmetric Aziridination of Imines

VINYLAZIRIDINES IN ORGANIC SYNTHESIS

Direct Synthesis of Vinylaziridines

Ring–opening Reactions with Nucleophiles

Isomerization Including Rearrangement

Cycloaddition

Electron Transfer to Vinylaziridines

ASYMMETRIC SYNTHESES WITH AZIRIDINECARBOXYLATE AND AZIRIDINEPHOSPHONATE BUILDING BLOCKS

Preparation of Aziridine–2–carboxylates and Aziridine–2–phosphonates

Reactions of Aziridine–2–carboxylates and Aziridine–2–phosphonates

Applications in Natural Product Syntheses

SYNTHESIS OF AZIRIDINES

Overview and General Features

METALATED EPOXIDES AND AZIRIDINES IN SYNTHESIS

Metalated Epoxides

Metalated Aziridines

METAL–CATALYZED SYNTHESIS OF EPOXIDES

Oxidants Available for Selective Transition Metal–catalyzed Epoxidation

Epoxidations of Olefins Catalyzed by Early Transition Metals

Chromium–, Molybdenum–, and Tungsten–catalyzed Epoxidations

Manganese–catalyzed Epoxidations

Rhenium–catalyzed Epoxidations

Iron–catalyzed Epoxidations

Ruthenium–catalyzed Epoxidations

CATALYTIC ASYMMETRIC EPOXIDE RING–OPENING CHEMISTRY

Enantioselective Nucleophilic Addition to Meso–Epoxides

Kinetic Resolution of Racemic Epoxides

Enantioselective Rearrangements of Epoxides

EPOXIDES IN COMPLEX MOLECULE SYNTHESIS

Synthesis of Complex Molecules by Intramolecular Ring–opening of Epoxides with Heteronucleophiles

Synthesis of Complex Molecules by Ring–opening of Epoxides with C–Nucleophiles

Epoxy Glycals

Synthesis of Complex Molecules by Rearrangement Reactions of Epoxides

VINYLEPOXIDES IN ORGANIC SYNTHESIS

Synthesis of Vinylepoxides

Transformations of Vinylepoxides

THE BIOSYNTHESIS OF EPOXIDES

Cytochrome P450 Monooxygenases

Flavin–dependent Epoxidases

Dioxygenases

Epoxidation through Dehydrogenation

Dehalogenases

AZIRIDINE NATURAL PRODUCTS –

DISCOVERY, BIOLOGICAL ACTIVITY AND BIOSYNTHESIS

Mitomycins and Related Natural Products

The Azinomycins

Other Aziridine Natural Products

EPOXIDES AND AZIRIDINES IN CLICK CHEMISTRY

Epoxides in Click Chemistry

Aziridines in Click Chemistry

Aziridinium Ions in Click Chemistry

Note: Product cover images may vary from those shown
3 of 4

Loading
LOADING...

4 of 4
"... should therefore be included in the library of every chemistry department. Experts in the field of catalysis and organic synthesis in both academia and industry will value the book as a very important "spring–loaded" source of information."

Angewandte Chemie

Note: Product cover images may vary from those shown
5 of 4
Note: Product cover images may vary from those shown
Adroll
adroll