With its coverage of the theory, practice and latest achievements in x–ray crystallography, this book will benefit any researcher in structural biology.
Albrecht Messerschmidt is head of a research group at Max–Planck–Institute for Biochemistry in Martinsried, Germany, department of proteomics and signal transduction headed by Matthias Mann. He gained his PhD in Crystallography at the Humboldt University in Berlin under Bill Kleber. After working on the X–ray crystallography of small biological molecules he moved to the field of X–ray crystallography of biomacromolecules, working in the department of structural research under Nobel laureate Robert Huber. He gained his lecturing qualification in the field of physical biochemistry at the faculty of biology of the University of Constance in 1996, where he was appointed extraordinary professor in 2002.
The author has published great number of scientific papers and is one of the editors of the three volume Handbook of Metalloproteins, published by Wiley.
Principles of X–ray Diffraction by a Crystal
Methods for Solving the Phase Problem
Model Building and Refinement
Time–resolved X–ray Crystallography
PART B CASE STUDIES FOR DIFFERENT KINDS OF X–RAY CRYSTAL STRUCTURE DETERMINATION OF BIOMACROMOLECULES
Space Group Determination and Data Reduction
Phase Determination by MIRAS Technique
Phase Determination by MAD Technique
Phase Determination by Molecular Replacement
Difference Fourier Technique
Map Improvement by NCS Averaging and other Methods
Automated Model Building
Structure Validation and PDB–Submission
" this book is reasonably well organized and covers all the relevant theory and much of the practical applications of the field." (Journal of the American Chemical Association, August 6, 2008)
I would highly recommend this book to someone who is thinking about or already using X–ray crystallography. (The Yale Journal of Biology and Medicine, March 2008)