Modern Biooxidation. Enzymes, Reactions and Applications

  • ID: 2183107
  • Book
  • 318 Pages
  • John Wiley and Sons Ltd
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Filling a gap in the literature, leading expert editor5s and top international authors present he field of biooxidation from an academic and industrial point of view, taking many examples from modern pharmaceutical research. Topics range from the characterization to technical applications of different oxidoreductases, making this volume of high interest not only for those working in biotechnology but also for organic synthetic chemists, among others.

Keywords:

  • Biocatalytic Applications of PQQ–and FAD–Dependent Dehydrogenases, Laccase, Baeyer–Villiger Monooxygenases, and Cytochrome P450 Monooxygenases
  • Bioreactors for Drug–Discovery, –Development and –Biotechnology
  • Engineering Substrate Specificity; Enantio–and Regioselectivity
  • Approaches to Cofactor Recycling and Substituting
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1. INTRODUCTION AND HISTORY

2. BIOOXIDATION FOR MEDICAL AND PHARMACEUTICAL RESEARCH

2.1 Preparation of Drug Metabolites Using Fungal and Bacterial Strains

2.2 Liver Monooxygenases

2.3 Recombinant Human Liver Monooxygenases in Pharmacological Research

2.4 Human Cytochrome P450 Monooxygenases –

A General Model of Substrate Specificity and Regioselectivity

2.5 Steroid Oxidation

3. BIOOXIDATION FOR BIOCATALYSIS AND ORGANIC SYNTHESIS

3.1 Selective Microbial Oxidations in Industry

3.2 PQQ– and FAD–Dependant Oxidases

3.3 Laccases and their Applications

3.4 Dioxygenases and their Applications

3.5 Heme Monooxygenases: A Superfamily, their Substates and their Applications

3.6 Electroenzymologie with Monooxygenases: Challenges, Perspectives and Practical Considerations

3.7 Baeyer–Villiger Monooyxgenases

3.8 Heme Monooxygenases: The Reductase Issue

3.9 A Modular Approach to Biotransformation Using Microbial Cytochromes

4. PLANT MONOOXYGENASES AND THEIR APPLICATIONS

5. COFACTOR REGENERATION

6. BIOOXIDATION IN INDUSTRY

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Rolf D. Schmid
Vlada Urlacher
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