Chiral Separation Techniques. A Practical Approach. 3rd, Completely Revised and Updated Edition

  • ID: 2183108
  • Book
  • 641 Pages
  • John Wiley and Sons Ltd
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Chirality describes the fact that a particular molecule can have a "right–hand" structure or its mirrored "left–hand" structure, both of which may display very different characteristics. For example, a "right–hand" structure can be an important active substance for a drug while its "left–hand" variation is highly toxic. For this reason, chiral separation techniques are indispensable for production and safety testing in biotechnology, food and pharmaceutical industries.

Thoroughly revised, with either entirely new or completely updated contents, this is a practical manual for the small and large–scale preparation of enantiomerically pure products. The result is a vital resource for meeting the highest purity standards in the manufacture of chiral pharmaceuticals, food additives and related compounds. All the approaches covered here are highly relevant to modern manufacturing and quality control schemes in the pharmaceutical and biotech industries, addressing the increasingly important issue of drug safety in view of tougher regulatory standards worldwide.
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1 Enantiomeric separations using macrocyclic glycopeptide stationary phases

2 The Role of Polysaccharides in Chiral Separations by Liquid Chromatography and Capillary Electrophoresis

3 Analytical and preparative potential of immobilized polysaccharide–derived chiral stationary phases

4 Chiral separations using supercritical fluid chromatography

5 Chiral ligand exchange in HPLC and CE

6 Advances in Simulated Moving Bed Chromatographic separations

7 Less common applications of enantioselective HPLC using the SMB technology in the pharmaceutical industry

8 Enatiomer Separation by Chiral Crown Ether Stationary phases

9 Chiral Separation of amino acids and hydroxy acids in HPLC with copper(II) complexes added to the eluent

10 Chiral Capillary Electrophoresis

11 Techniques in preparative chiral separations

12 Separation of enantiomers using molecularly imprinted polymers

13 Enantioselective Biosensors

14 Chiral analysis using CEC–UV and CEC–MS

15 Chiral analysis using MEKC–UV and MEKC–MS

16 Polarimeter Chiral Detectors in Enantioseparations

17 Preparative Chiral Chromatography – a powerful and efficient tool in drug discovery
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From reviews of the first edition:

′Publication of this book is timely, and of immense value to the growth of this field′

Journal of Food Science

′A team of experts from academic and industrial laboratories throughout the world have compiled their findings and experience to make this book an exceptionally timely and unique contribution to the field′

European Journal of Drug Metabolism

′The dense mass of information contained in this book will make it a valuable resource ...′

Chemical Engineering Research

′... this is a worthwhile addition to the expanding chiral literature and the book should be of value to those working in this field′

The Analyst

′This book is a valuable reference and should find a readership among scientists in the field of pharmaceutical sciences.′

Chirality

′...this book can be recommended to analysts confronted with chiral separations.′

Journal of Chromatography A

′In conclusion this is a useful volume written on the whole by workers in the field and deserving a place in the bench of doing chiral separations.′

Human and Experimental Technology

"Outstanding international contributors have agreed to share their knowledge and experience with the engaged readers and have compiled a valuable source in this special important scientific field. Each chapter of this book represents an overview of its chosen topic."

– Advances in Food Sciences, 2001; Vol. 23; No. 1

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