The Power of Functional Resins in Organic Synthesis

  • ID: 2183171
  • Book
  • 683 Pages
  • John Wiley and Sons Ltd
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Since work–up procedures in industry are both time– and energyconsuming processes, the interest in solid phases for industrial purposes is very high. For this reason, fast and simple synthesis has become a major focus of research over the last few years. Applications of solid–phase synthesis range from biomolecules and small molecules to high–throughput separation purification, combinatorial high–throughput chemistry right up to nanotechnologies.

While many books cover solid phase synthesis and combinatorial synthesis, this is unique in exclusively covering the other aspects of solid–phase synthesis. As such, it contains everything you need to know – from supported reagents, to scavengers, resins, and the synthesis of natural products.

An invaluable companion for all chemists and biochemists working in university research and industry.
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INTRODUCTION

The (Classic Concept of) Solid Support

Molecularly Imprinted Polymers

Nanoparticles Functionalized with Bioactive Molecules: Biomedical Applications

SOLID–SUPPORTED REAGENTS AND SCAVENGERS

Oxidizing and Reducing Reagents

Base and Acid Reagents

Nucleophilic, Electrophilic, and Radical Reactions

Coupling and Introducing Building Block Reagents

Supported/Tagged Scavengers for Facilitating High–Throughput Chemistry

Metal Scavengers

RESIN–BOUND CATALYSTS

Polymer–Supported Organocatalysts

Transition Metal Catalysts

Chiral Auxiliaries on Solid Support

Immobilized Enyzmes in Organic Synthesis

RESINS FOR SOLID–PHASE SYNTHESIS

Acid–Labile Resins

Base/Nucleophile–Labile Resins

Safety–Catch and Traceless Linkers/Resins in SPOS

Photolabile and Miscellaneous Linkers/Resins

SOLID–PHASE SYNTHESIS OF BIOMOLECULES. THE STATE OF THE ART (FROM THE RESIN POINT OF VIEW)

Peptides

Oligonucleotides and their Derivatives

Oligosacharides

High Throughput Synthesis of Natural Products
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Fernando Albericio
Judit Tulla–Puche
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