Post-translational Modification of Protein Biopharmaceuticals

  • ID: 2183191
  • Book
  • 390 Pages
  • John Wiley and Sons Ltd
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From the leading author in the field, known around the world for his work and his authoritative publications, the contents of this book have been selected so as to reflect their relative importance for biopharmaceuticals. As a result, around half of the book is devoted to protein glycosylation, while the remainder is made up of other modifications, such as carboxylation, hydroxylation, sulfation, amidation and proteolytic processing. A final section addresses the latest trend of engineering the modification pattern to improve a given biopharmceutical, presenting several recent case studies of successful posttranslational engineering.

This first authoritative overview of the topic is an indispensable guide for drug developers and drug manufacturers with an interest in protein pharmaceuticals.
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1 Post translational modifications in the context of therapeutic proteins; an introductory overview (Walsh)

2 Protein glycosylation; the basic science (Brookes)

3 Mammalian cell lines and glycosylation; a case study (Butler)

4 Antibody glycosylation (Jefferis)

5 Gonadotropins and the importance of glycosylation (Ulloa–Aguirre)

6 Yeast glycosylation and engineering in the context of therapeutic proteins (Sethuraman)

7 Insect cell glycosylation patterns in the context of biopharmaceuticals (Jarvis)

8 Getting Bacteria to glycosylate (Kowarik, Feldman)

9 Glycoengineering of Erythropoietin (Elliott)

10 Glycoengineering: Cerezyme as a case study (Van Patten, Edmunds)

11 Carboxylation and Hydroxylation (Brown, Stenberg)

12 C–Terminal a–Amidation (Mehta, Carpenter)

13 Disulfide bond formation (Collett)

14 Engineering in a PTM: PEGylation (Bonora, Veronese)

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"The authors and editor should be congratulated on bravely planting a first flag with a book that will stimulate many." (ChemMedChem, 2010)

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