Dynamic Combinatorial Chemistry

  • ID: 2183203
  • Book
  • 211 Pages
  • John Wiley and Sons Ltd
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This long–awaited first book on this exciting new field in organic and supramolecular chemistry explains the fundamentals as well as possible applications of Dynamic Combinatorial Chemistry (DCC). Authored by the ′Who′s Who′ of DCC it spans the whole range of topics: catalysts, sensors, polymers, ligands, receptors, concluding with a look at future developments and perspectives.

All set to become the standard text in the field, this one–stop reference contains everything organic, catalytic, polymer, physical and biochemists need to know.
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HISTORY AND PRINCIPLES OF DYNAMIC COMBINATORIAL CHEMISTRY

Introduction

History

Exercising Control over a DCL to Influence Species Distribution

Designing a Dynamic Combinatorial System

Conclusions

THE PRACTICE OF DYNAMIC COMBINATORIAL LIBRARIES: ANALYTICAL CHEMISTRY, EXPERIMENTAL DESIGN, AND DATA ANALYSIS

Introduction

Analytical Methods

Experimental Design

Data Analysis

Conclusions

DEVELOPMENT OF SYNTHETIC RECEPTORS USING DYNAMIC COMBINATORIAL CHEMISTRY

Introduction

Experimental Considerations

Selected Examples

Conclusion

DYNAMIC COMBINATORIAL CHEMISTRY FOR CATALYTIC APPLICATIONS

Introduction

Dynamic Combinatorial Approaches to Cage Catalysts

Dynamic Combinatorial Approaches to Transition Metal Catalysts

Conclusions

DYNAMIC COMBINATORIAL CHEMISTRY: LIGANDS FOR BIOMOLECULES

Ligand Discovery

DCC Strategies in Targeting Biological Systems

Dynamic Diversity Generation for Biological Systems

Applications of DCC in Biological Systems

Conclusions and Future Prospects

POLYMERS FORMED BY DYNAMIC COMBINATORIAL CHEMISTRY

Introduction

Dynamics in Polymers

Biasing Composition by Molecular Recognition

Conclusions and Outlook

ANALYTICAL APPLICATIONS OF DYNAMIC COMBINATORIAL CHEMISTRY

Introduction

Fluorescent Sensors

Colorimetric Sensors

Molecular Timers

Conclusions

TRENDS AND PERSPECTIVES

Introduction

Dynamic Combinatorial Libraries as Molecular Networks

Perspectives

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Joost Reek received his PhD in 1996 under Prof. R.J.M. Nolte in the field of supramolecular chemistry. Following this, he joined Prof. M.J. Crossley?s group in Sydney as a postdoctoral fellow, where he gained experience in porphyrin chemistry and Dendrimers. In 1998 he became a lecturer in the group headed by Prof. P.W.N.M. Van Leeuwen with research activities focusing on transition metal catalysis, and during this period began his own line of research into Supramolecular transition metal chemistry. He has received numerous grants, including the prestigious VICI grant, and in 2005 became a member of the young Royal Netherlands Academy of Arts and Sciences (KNAW). One year later he was appointed full professor at the University of Amsterdam. Dr. Reek currently heads a research group of about 30 people, comprising 18 PhD students and 8 postdocs, working on various topics related to supramolecular chemistry and transition metal catalysis.

Sijbren Otto received his Ph.D. degree in physical organic chemistry from the University of Groningen in the Netherlands in the group of Prof. Jan B.F.N. Engberts. After one year in the United States as a postdoctoral researcher with Prof. Steven L. Regen (Lehigh University, Bethlehem, Pennsylvania) he received a Marie Curie Fellowship and moved to the University of Cambridge, where he worked for two years with Prof. Jeremy K.M. Sanders on dynamic combinatorial libraries. He started his independent research career in 2001 as a Royal Society University Research Fellow in Cambridge. In 2009 he moved to the University of Groningen in the Netherlands where he is associated with the newly created Centre for Systems Chemistry.

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