Separation of Enantiomers. Synthetic Methods - Product Image

Separation of Enantiomers. Synthetic Methods

  • ID: 2183387
  • Book
  • 312 Pages
  • John Wiley and Sons Ltd
1 of 4
In one volume this book summarizes the most common synthetic methods for the separation of enantiomers, allowing an easy comparison of the different strategies described in the literature.

Alongside classical and reagent–based methods, the authors consider kinetic resolutions, dynamic kinetic resolutions, divergent reactions of racemic mixtures, and enzymatic examples of such processes, as well as a number of "neglected" cases not previously brought together.

The result is a thorough introduction to the field plus a long–needed overview of the relevant chemical, biological, and physical methods and their applications. Newcomers to the field, students as well as experienced synthetic chemists will benefit from the highly didactic presentation: Every method is presented in detail, from relatively simple separation problems to advanced synthetic resolution methods.

Note: Product cover images may vary from those shown
2 of 4
INTRODUCTION: A SURVEY OF HOW AND WHY TO SEPARATE ENANTIOMERS

Classical Methods

Kinetic Resolution (′KR′)

Dynamic Kinetic Resolution (′DKR′)

Divergent Reactions of a Racemic Mixture (′DRRM′)

Other Methods

STOICHIOMETRIC KINETIC RESOLUTION REACTIONS

Introduction

Kinetic Treatment

Chiral Reagents and Racemic Substrates

Enantiodivergent Formation of Chiral Product

Enantioconvergent Reactions

Diastereomer Kinetic Resolution

Some Applications of Kinetic Resolution

Conclusion

CATALYTIC KINETIC RESOLUTION

Introduction

Kinetic Resolution of Alcohols

Kinetic Resolution of Epoxides

Kinetic Resolution of Amines

Kinetic Resolution of Alkenes

Kinetic Resolution of Carbonyl Derivatives

Kinetic Resolution of Sulfur Compounds

Kinetic Resolution of Ferrocenes

Conclusions

APPLICATION OF ENZYMES IN KINETIC RESOLUTIONS, DYNAMIC KINETIC RESOLUTIONS AND DERACEMIZATION REACTIONS

Introduction

Kinetic Resolutions Using Hydrolytic Enzymes

Dynamic Kinetic Resolution

Deracemization

Enantioconvergent Reactions

Conclusions

DYNAMIC KINETIC RESOLUTION (DKR)

Introduction

Definition and Classification

Dynamic Kinetic Resolution (DKR)

Mathematical Expression

DKR–Related Methods

Concluding Remarks

ENANTIODIVERGENT REACTIONS: DIVERGENT REACTIONS ON A RACEMIC MIXTURE AND PARALLEL KINETIC RESOLUTION

Introduction: The Conceptual Basis for Kinetic Resolution and Enantiodivergent Reactions

Divergent RRM Using a Single Chiral Reagent: Ketone Reduction

Divergent RRM under Oxidative Conditions

Organometallic Reactions and Regiodivergent RRM

Regiodivergent RRM in Selective Reactions of Difunctional Substrates

Divergent RRM Using Two Chiral Reagents: Parallel Kinetic Resolution (PKR)

Conclusion

RARE, NEGLECTED AND POTENTIAL SYNTHETIC METHODS FOR THE SEPARATION OF ENANTIOMERS

Resolution through the Selfish Growth of Polymers: Stereoselective Polymerization

Resolution through Photochemical Methods

Combinations of Crystallization and Racemization

Destruction then Recreation of Stereocentres: Enantioselective Protonations

Dynamic Combinatorial Chemistry

Asymmetric Autocatalysis

Miscellaneous

Concluding Remarks

Index
Note: Product cover images may vary from those shown
3 of 4

Loading
LOADING...

4 of 4
An Associate Professor at The University of Sydney′s School of Chemistry, Matthew Todd gained his BA and PhD from Cambridge University, UK, where he later became a Fellow in Chemistry. Prior to taking up his current position, he was a Wellcome Trust postdoctoral fellow at the University of California, Berkeley, USA, from 1999 to 2000, and then became a lecturer in organic chemistry at the Department of Chemistry, Queen Mary, University of London from 2001 to 2005. Prof. Todd′s research group is investigating synthetic methodology, responsive metal complexes, and asymmetric catalysis. He has received awards for his work in open science, most notably his creation of the Open Source Malaria consortium that is trialling a new model of drug discovery.
Note: Product cover images may vary from those shown
5 of 4
Note: Product cover images may vary from those shown
Adroll
adroll