Thus, drug discovery has turned to the novel field of peptidomimetics, i. e. to design non–peptide compounds mimicking the pharmacophore and thus the activity of the original peptide. These novel compounds open up new perspectives in drug design by providing an entire range of highly specific pharmaceuticals that have a high bioavailability.
In particular, the following classes of pseudo–peptides are introduced and examined with regard to their chemical properties, pharmacological activity, as well as practical aspects of synthesis:
∗ Pyrrole–imidazole polyamides
∗ DNA–like peptide nucleic acids
∗ Alpha–helical peptide nucleic acids
∗ DNA–cleaving pseudo–peptides
The first work drawing together knowledge gained on different types of pseudo–peptides with drug properties, this book is an essential resource for drug developers and bioorganic chemists working with those compounds.
Beta–peptides, gamma–peptides and isosteric backbones: New scaffolds with controlled shapes
Regulation of gene expression with pyrrole–imidazole polyamides
Peptide nucleic acid: A pseudo–peptide with DNA–like properties
Alpha–helical peptide nucleic acids
"... the editor of this book has brought together a number of excellent reviews for obtaining up–to–date information in the areas of research covered, and I highly recommend it." (Victor J. Hruby, Department of Chemistry, University of Arizona, Journal of Medicinal Chemistry, 2005, Vol. 48, No. 8)
"In view of the thoroughly up–to–date coverage of the topics in this book, it can be highly recommended for drug developers and bioorganic chemists working with pseudopeptides, and for all researchers who are interested in the field of nucleic acid chemistry." (Angewandte Chemie, Volume 43, Oct. 2004)