DNA-Pharmaceuticals. Formulation and Delivery in Gene Therapy, DNA Vaccination and Immunotherapy

  • ID: 2183686
  • Book
  • 275 Pages
  • John Wiley and Sons Ltd
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With its focus on a completely novel class of pharmaceuticals, this book collates the hitherto scarce literature about DNA drug formulation keenly desired by biotechnologists, molecular biologists and pharmacists, as well as those working in the biotechnological and pharmaceutical industries.

As such, this volume presents a wide range of gene delivery systems needed for different therapeutic applications. It fills the gap between research and clinical trials and describes pharmaceutical fundamentals for the development of efficient DNA pharmaceuticals.

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Preface

DNA Vaccines: an Overview

DNA as a Pharmaceutical: Regulatory Aspects

From Bulk to Delivery: Plasmid Manufacturing and Delivery

Minimized, CpG–Depleted and Methylated DNA Vectors: Towards Perfection in Nonviral Gene Therapy

Localized Nucleic Acid Delivery: a Discussion of Selected Methods

DNA Needle Injection

Needleless Jet Injection of Naked DNA von Nonviral in vivo Gene Transfer

Plasmid Inhalation: Delivery to the Airways

Hydrodynamic Gene Delivery

DNA Pharmaceuticals for Skin Diseases

Electrotransfection: an Overview

Electrogenetransfer in Clinical Applications

Cancer Inhibition in Mice after Systematic Application of Plasmid Driven Expression of Small Interfering RNAs

Index

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Martin Schleef
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