This book provides a detailed overview of how and why such damage occurs, exploring the mechanisms whereby oxygen interacts with living cells, but particularly focusing upon the biochemical and physiological adaptations of hypoxia and their biological and medical relevance. It includes information about the cellular and molecular mechanisms of oxygen–sensing from bacteria to eukaryotic animal cells, focusing on the regulatory role of oxygen on ion channels and gene expression in various organs and tissues.
Other key topics include:
Components of the signaling pathway linking oxygen tension and transcription
The possible role of reactive oxygen intermediates in the regulation of gene expression and ion channel gating
How recent studies have characterized oxygen–sensitive ion channels
Oxygen–sensitive ion channels as mediators of the vasomotor responses to hypoxia
Changes produced by hypoxia or redox alterations
This book should be of interest to cellular and molecular biologists, pulmonary specialists, physiologists, biophysicists, as well as any professional conducting research in this field.
J. López–Barneo, E.K. Weir.
SECTION 1: GENERAL PRINCIPLES OF OXYGEN SENSING.
1. Cellular Metabolism of Oxygen: Brief Overview and Current Aspects on Peroxynitrite and Singlet Oxygen.
K. Briviba, H. Sies.
2. Reactive Oxygen Intermediates as Mediators for Regulating Ion Channel Activity and Gene Expression in the Process of Cellular Oxygen Sensing.
3. Critical Cysteine Residues in the Inactivation Domains of Voltage–Activated Potassium Channels.
SECTION 2: OXYGEN SENSORS IN BACTERIA AND PLANTS.
4. Nitrogen Fixation and Oxygen Sensing.
E. Soupène, P. Boistard.
5. Oxygen Transducers that Regulate Behavior in Bacteria.
6. Oxygen Sensing in Plants.
SECTION 3: OXYGEN SENSING AND EUCHARYOTIC GENE EXPRESSION:.
7. Oxygen–Regulated Gene Expression: A Widely Operative System Recognized Through Studies of Erythropoietin Regulation.
P.J. Ratcliffe, J.M. Gleadle, P.H. Maxwell, J.F. O′Rourke, C.W. Pugh, S.M. Wood.
8. Hypoxic Control of Erythropoietin Gene Expression.
J. Caro, S. Salceda.
9. Regulation of Hypoxia–Inducible Factor 1 Activity.
L.E. Huang, H.F. Bunn.
10. Evidence for Hydrogen Peroxide as a Signal Transduction Molecule in Oxygen–Dependent Regulation of Gene Expression.
M.F. Czyzyk–Krzeska, S.L. Kroll, W.R. Paulding.
SECTION 4: ION CHANNELS AND FUNCTIONAL RESPONSES TO HYPOXIA.
Part 1: Neurosecretory Mechanisms.
11. Oxygen–Regulation Ion Channels: Functional Roles amd Mechanisms.
J. López–Barneo, R. Montoro, P. Ortegá–Sáenz, J. Ureña.
12. Oxygen Sensing in Arterial Chemoreceptors. Role of a Novel Oxygen–Dependent Potassium Channel.
13. Potassium Channels in Carotid Body Type I Cells and their Sensitivity to Hypoxia:.
Studies in Chronically Hypoxic and Developing Rats.
14. Oxygen Sensing by Rat Chromaffin Cells: Adrenal Medulla and Carotid Body Contrasted.
C.A. Nurse, A. Jackson, R.J. Thompson, H. Zong.
15. Mechanisms of Oxygen Chemosensitivity in a Model Cell Line System.
L. Conforti, W.H. Zhu, S. Kobayashi, D.E. Millhorn.
Part 2: Vascular Smooth Muscle.
16. Oxygen Sensing in the Pulmonary Vasculature.
E.K. Weir, H.L. Reeve, S. Tolarova, D.N. Cornfield, D.P. Nelson, S.L. Archer.
17. Mechanisms of Hypoxic Pulmonary Vasoconstriction: The Role of Oxygen–Sensitive Voltage–Gated Potassium Channels.
18. Diversity of Potassium Channel Expression in Pulmonary Vascular Smooth Muscle Cells.
S.L. Archer, H.L. Reeve, J. Huang, D.P. Nelson, S. Tolarova, E. Michelakis, E.K. Weir.
19. Calcium Channels, Cytosolic Calcium and the Vasomotor Responses to Hypoxia.
A. Franco–Obregón, J. Ureña, T. Smani, S. Iwabuchi, J. López–Barneo.
20. Hypoxia, Adenosine, and KATP Channels of Coronary Arterial Smooth Muscle.
C. Dart, C.S. Davie, J.M. Quayle, G.C. Wellman, N.B. Standen.
SECTION 5: OXYGEN SENSING IN NERVE CELLS.
21. Oxygen Sensing in Neurons: Direct and Indirect Modulation of Ion Channels.
22. Ischemia and Oxidative Regulation of Neuronal Calcium–Permeable AMPA Receptors.
L. Dugan, D.M. Turetsky, D. Choi.
SECTION 6: SENSITIVITY TO HYPOXIA.
23. Short– and Long–Term Modulation of Oxygen Sensitivity: Lessons from the Carotid Body.
P. Kumar, D.R. Pepper.
24. Sensitivity to Physiologic Hypoxia.