Only 30 years ago there was very little interest in the study of the pathology of HCC due to the fact that most HCCs were detected in the advanced stages when patients were given a prognosis of only three to six months. In more recent years there have been enormous advances made in the clinical diagnosis of liver cancer, in particular through imaging and the establishment of follow–up systems in high–risk populations.
This book covers the vast advances made in clinical diagnosis aiding earlier detection, while addressing the recent progress made in treatment of HCC to enable successful therapy.
It reviews the full range of pathological information of HCC based on the study of surgical cases and biopsy materials, along with images, to help compare findings that may be encountered by pathologists.
The developments in imaging have also led to the identification of equivocal small nodular lesions suggestive of premalignant lesions or early–stage HCC. These present a diagnostic and therapeutic challenge for both pathologists and clinicians. This text makes special reference to developments in detection of early–stage HCC and premalignant lesions which can increase effective treatment.
1. The background to hepatocellular carcinoma and the liver.
2. Premalignant lesions of hepatocellular carcinoma.
3. Pathomorphologic characteristics of early–stage small hepatocellular carcinoma.
4. Morphologic evolution of hepatocellular carcinoma: from early to advanced.
5. Angioarchitecture of hepatocellular carcinoma.
6. Advanced hepatocellular carcinoma.
7. Multicentric occurrence of hepatocellular carcinoma.
8. Combined hepatocellular carcinoma and cholangiocarcinoma.
9. Nodular lesions mimicking hepatocellular carcinoma.
10. Biopsy diagnosis of tumorous lesions of the liver.
11. Chemoprevention of hepatocellular carcinoma.