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Allergy and Allergic Diseases. 2 Volume Set. 2nd Edition

  • ID: 2222460
  • Book
  • 2184 Pages
  • John Wiley and Sons Ltd
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Allergy and Allergic Diseases is an outstanding reference source on all aspects of allergy and allergic diseases. Covering virtually every allergic condition, from the immunological and molecular basis of the allergic response to future trends in allergic disease prevention, this new international editorial team lead by Professor Kay, have completely revised and updated the text, from both a scientific and clinical perspective.

The two volume second edition consists of more than 1800 pages contained in 98 chapters. The first volume covers growing areas on the immunological basis of allergy, particularly regulatory T cells, environmental factors in IgE production and innate immunity, as well as up to date accounts of the cells and mediators of allergic inflammation. The sections on pharmacology, physiology, allergens and animals models have also been fully revised. Volume 2 , the clinical section, contains detailed accounts of allergic conjunctivo–rhinitis, asthma, eosinophilic disorders, allergy and the skin, anaphylaxis, food and drug allergy and allergy prevention. Current approaches to treatment are addressed with emphasis on internationally agreed guidelines; there is a substantial section on allergen immunotherapy, including recent advances.

The price includes a fully searchable CD ROM of the text and a database of 100 colour images.

References were added to the text up until the book went to press, making this the most up–to–date book available in the field.

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List of Contributors ix

Foreword xvii

Preface xviii

VOLUME 1 The Scientific Basis of Allergy

Part 1 Immunology of the Allergic Response

1 Allergy and Hypersensitivity: History and Concepts 3A. Barry Kay

2 Development of Allergy and Atopy 23Catherine Thornton and Patrick G. Holt

3 T Cells and Cytokines in Asthma and Allergic Inflammation 48Chris Corrigan

4 Regulatory T Cells and Other Tolerogenic Mechanisms in Allergy and Asthma 83Catherine Hawrylowicz and Cezmi A. Akdis

5 IgE and IgE Receptors 103Brian J. Sutton, Andrew J. Beavil, Rebecca L. Beavil, and James Hunt

6 Immunoglobulin Gene Organization and Expression and Regulation of IgE 119Hannah J. Gould and David J. Fear

7 Environmental Factors in IgE Production 141Anne Tsicopoulos, Catherine Duez, and Andrew Saxon

8 Antigen–presenting Dendritic Cells and Macrophages 166Bart N. Lambrecht and Hamida Hammad

9 Innate Immunity in Allergic Disease 187Ian Sabroe

10 Signal Transduction in Allergic and Inflammatory Cells 203Rafeul Alam

Part 2 Inflammatory Cells and Mediators

11 Mast Cells: Biological Properties and Role in Health and Allergic Diseases 217Peter Bradding and Glenn Cruse

12 Eosinophils: Biological Properties and Role in Health and Disease 258Simon P. Hogan, Helene F. Rosenberg, Redwan Moqbel, Simon Phipps, Paul S. Foster, Paige Lacy, A. Barry Kay, and Marc E. Rothenberg

13 Neutrophils: Biological Properties and Role in Health and Allergic Diseases 295Alison M. Condliffe, Andrew S. Cowburn, and Edwin R. Chilvers

14 Basophils: Biological Properties and Role in Allergic Diseases 320Gianni Marone, Giuseppe Spadaro, and Arturo Genovese

15 Leukocyte Adhesion in Allergic Inflammation 337Michelle J. Muessel and Andrew J. Wardlaw

16 Airway Epithelium 366Pedro C. Avila and Robert P. Schleimer

17 Airway Vascularity in Asthma 398John W. Wilson

18 Fibroblasts and the Extracellular Matrix 412Lynne A. Murray, William G. Glass, Anuk M. Das, and Geoffrey J. Laurent

19 Immune Complexes and Complement: Their Role in Host Defense and in Disease 436Michael M. Frank and C. Garren Hester

20 Bradykinin Pathways and Allergic Disease 451Allen P. Kaplan

21 Chemokines 471James E. Pease and Timothy J. Williams

22 Neurotrophins 494Wolfgang A. Nockher, Sanchaita Sonar, and Harald Renz

23 Neuropeptides 511David A. Groneberg and Axel Fischer

24 Late–phase Allergic Reactions in Humans 524Yee–Ean Ong and A. Barry Kay

Part 3 Pharmacology

25 Antihistamines 551F. Estelle, R. Simons, and Keith J. Simons

26 Lipid Mediators: Leukotrienes Prostanoids Lipoxins and Platelet–activating Factor 566Sophie P. Farooque, Jonathan P. Arm, and Tak H. Lee

27 Theophylline and Isoenzyme–selective Phosphodiesterase Inhibitors 634Mark A. Giembycz

28 Adrenergic Agonists and Antagonists 668Tony R. Bai

29 Cholinergic Antagonists 683Nicholas J. Gross

30 Antileukotriene Agents 694Graeme P. Currie and Brian J. Lipworth

31 Glucocorticosteroids 715Peter J. Barnes

32 Immunomodulating Drugs 732Iain A.M. MacPhee

Part 4 Physiology

33 Physiologic Aspects of Asthma 749Philip W. Ind and Neil B. Pride

34 Aerosol Delivery Systems 768Thomas G. O Riordan and Gerald C. Smaldone

35 Bronchial Hyperresponsiveness 783Guy F. Joos

36 Exercise–induced Bronchoconstriction: Animal Models 794Arthur N. Freed and Sandra D. Anderson

37 Exercise–induced Bronchoconstriction: Human Models 808Arthur N. Freed and Sandra D. Anderson

38 Sensory and Autonomic Nervous System in Asthma and Rhinitis 823Bradley J. Undem and Kevin Kwong

39 Mucus and Mucociliary Clearance in Asthma and Allergic Rhinitis 840Duncan F. Rogers

40 Biology of Vascular Permeability 857Peter Clark

41 Airway Smooth Muscle 874Stuart J. Hirst

Part 5 Allergens

42 Biochemistry of Allergens and Recombinant Allergens 895Rudolf Valenta

43 Host Responses to Allergens 913Wayne R. Thomas and Belinda J. Hales

44 Allergen Extracts and Standardization 928Ronald van Ree

45 Grass Tree and Weed Pollen 942Jean Emberlin

46 Fungi as Allergens 963Cathryn C. Hassett, W. Elliott Horner, Estelle Levetin, Laurianne G. Wild, W. Edward Davis, Samuel B. Lehrer, and John Lacey

47 Dust Mites and Asthma 984Thomas A.E. Platts–Mills and Judith A. Woodfolk

48 Animal Allergens 997Adnan Custovic and Angela Simpson

49 Airborne Allergens and Irritants in the Workplace 1017Xaver Baur

50 Allergens from Stinging Insects: Ants Bees and Vespids 1123Te Piao King and Rafael I. Monsalve

51 Cockroach Allergens Environmental Exposure and Asthma 1131Martin D. Chapman and Anna Pomés

52 Food Allergens 1146Ricki M. Helm and A. Wesley Burks

53 Latex Allergy 1164Robyn E. O Hehir, Michael F. Sutherland, Alexander C. Drew, and Jennifer M. Rolland

Part 6 Animal Models of Asthma

54 Primate Models of Allergic Asthma 1187Charles G. Plopper, Suzette M. Smiley–Jewell, Lisa A. Miller, Michelle V. Fanucchi, Michael J. Evans, Alan R. Buckpitt, Mark V. Avdalovic, Laurel J. Gershwin, Jesse P. Joad, Radhika Kajekar, Shawnessy D. Larson, Kent E. Pinkerton, Laura S. Van Winkle, Edward S. Schelegle, Emily M. Pieczarka, Reen Wu, and Dallas M. Hyde

55 Airway Remodeling in Small Animal Models 1202Clare M. Lloyd

56 Are Animal Models of Asthma Useful? 1214Reinhard Pabst


VOLUME 2 Allergic Diseases: Etiology Diagnosis and Treatment

Part 7 Etiology and Pathology

57 Genetics of Asthma and Atopic Dermatitis 1225Saffron A.G. Willis–Owen, Miriam F. Moffatt, and William O.C. Cookson

58 Epidemiology of Asthma Atopy and Atopic Disease 1239Debbie L. Jarvis, Seif O. Shaheen, and Peter Burney

59 The Allergy March 1259Ulrich Wahn

60 Outdoor Air Pollution and Allergic Airway Disease 1266Gennaro D Amato

61 Indoor Air Pollution 1279Paul Harrison, Rebecca Slack, and Sanjeev Bagga

62 Molecular Immunopathology of Allergic Disease 1290Susan Foley and Qutayba Hamid

Part 8 Diagnosis of Allergic Disease

63 Principles and Practice of Diagnosis and Treatment of Allergic Disease 1321Anthony J. Frew and A. Barry Kay

64 Skin Testing in Diagnosis and Management of Respiratory Allergic Diseases 1335Pascal Demoly, Anaïs Pipet, and Jean Bousquet

65 Allergy Testing in the Laboratory 1346Steven O. Stapel and Jörg Kleine–Tebbe

66 Measurement of Markers of Inflammation in Induced Sputum and Exhaled Air 1368Ian D. Pavord and Dominick E. Shaw

Part 9 Allergic Rhinoconjunctivitis and Immunotherapy

67 Definition and Classification of Allergic Rhinitis and Upper Airways Diseases 1383Wytske Fokkens and Jean Bousquet

68 Pathophysiology of Allergic Rhinitis 1402Peter H. Howarth

69 Management and Treatment of Allergic Rhinitis 1430Jean Bousquet and Michael A. Kaliner

70 Nasal Polyps and Rhinosinusitis 1454Wouter Huvenne, Paul Van Cauwenberge, and Claus Bachert

71 Ocular Allergy 1482Avinash Gurbaxani, Virginia L. Calder, and Susan Lightman

72 Mechanisms in Allergen Injection Immunotherapy 1510Stephen J. Till and Stephen R. Durham

73 Allergen Injection Immunotherapy: Indications and Practice 1522Hans–Jørgen Malling

74 Sublingual Immunotherapy 1543G. Walter Canonica and Giovanni Passalacqua

75 Novel Approaches to Allergen Immunotherapy 1555Mark Larché

Part 10 Asthma and its Treatment

76 Definition Clinical Features Investigations and Differential Diagnosis of Asthma 1567Piero Maestrelli, Gaetano Caramori, Francesca Franco, and Leonardo M. Fabbri

77 Asthma in Infancy and Childhood 1591John O. Warner

78 Pathogenesis of Asthma 1608Stephen T. Holgate

79 Pathology of Asthma 1632Peter K. Jeffery, A. Barry Kay, and Qutayba Hamid

80 Management of Chronic Asthma 1650Peter J. Barnes

81 Anti–IgE in Persistent Severe Allergic Asthma 1661Marc Humbert, Stephen T. Holgate, Howard Fox, and Jean Bousquet

82 Occupational Asthma 1687Paul Cullinan and Anthony J. Newman Taylor

83 New Drugs for the Treatment of Allergy and Asthma 1712Trevor T. Hansel, Ed Erin Onn, Min Kon, and Peter J. Barnes

Part 11 Eosinophil–associated Disease and Hypersensitivity Pneumonitis

84 Allergic Bronchopulmonary Aspergillosis 1743André–Bernard Tonnel, Stéphanie, Pouwels–Frys, and Isabelle Tillie–Leblond

85 Extrinsic Allergic Alveolitis/Hypersensitivity Pneumonitis 1757Michael C. Zacharisen and Jordan N. Fink

86 Pulmonary Eosinophilia 1779Jean–François Cordier and Vincent Cottin

87 Hypereosinophilic Syndromes 1802Hans–Uwe Simon

Part 12 Allergy and the Skin

88 Atopic Dermatitis 1813Julia D. Proelss and Thomas Bieber

89 Contact Dermatitis 1831David I. Orton and Carolyn M. Willis

90 Urticaria and Angioedema 1853Allen P. Kaplan

91 Mastocytosis 1878Nataliya M. Kushnir–Sukhov, Dean D. Metcalfe, and Jamie A. Robyn

Part 13 Anaphylaxis and Allergy to Food and Drugs

92 Anaphylaxis 1897M. Rosario Caballero, Stephen J. Lane, and Tak H. Lee

93 Food Allergy and Eosinophilic Gastroenteropathies 1921Scott H. Sicherer and Hugh A. Sampson

94 Drug Hypersensitivity 1943Werner J. Pichler

95 Hypersensitivity to Aspirin and other NSAIDs 1966Andrzej Szczeklik, Ewa NiLankowska–Mogilnicka, and Marek Sanak

96 Insect Sting Allergy 1980Ulrich R. Müller

Part 14 Prevention of Allergic Disease

97 Prevention of Allergic Disease 1997Susan L. Prescott and Bengt Björkstén

98 Prevalence of Atopic Disorders in a Developing World: Pitfalls and Opportunities 2020Maria Yazdanbakhsh, Taniawati Supali, and Laura C. Rodrigues


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A. Barry Kay
Jean Bousquet
Patrick G. Holt
Allen P. Kaplan
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