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Assisted Reproduction Techniques. Challenges and Management Options

  • ID: 2222866
  • Book
  • 466 Pages
  • John Wiley and Sons Ltd
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Assisted reproduction techniques have led to the birth of 4 million babies worldwide

Assisted reproduction techniques (ART), in particular in–vitro fertilization and intra–cytoplasmic sperm injection, are the most advanced forms of infertility treatment. They involve numerous counseling, medical, surgical and laboratory–based steps. At each step various problems and complications could be encountered that challenge even the most experienced ART practitioners. Moreover, patients with complex medical disorders may require ART, presenting further challenges.

Assisted Reproduction Techniques will stimulate resourceful thinking in the ART practitioner when faced with these challenges. It outlines various management options, the reasoning behind them, and the evidence on which they are based to enable the practitioner to choose the most suitable solution for the needs of each patient

Written by 122 internationally renowned experts, Assisted Reproduction Techniques follows the patient′s journey throughout the whole ART process, with chapters on:

  • Counseling and preparation
  • Ovarian stimulation
  • Oocyte retrieval
  • Embryo transfer
  • The luteal phase
  • The ART laboratory
  • The male patient
  • The ART pregnancy

Each of the 100 concise chapters includes clinical cases, background, evidence–based practical management options, preventive measures and key–point summaries of the important details.

Assisted Reproduction Techniques gives a wide–ranging practical guide to all those wishing to support couples who cannot conceive naturally.

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Contributors, xi

Preface, xxii

How to use this book, xxiii

Section 1: Counseling and preparation phase

1 Risk of cancer from ovarian stimulation, 3Nikos Kanakas, Miltiadis Pitsos and Themis Mantzavinos

2 Risk of early menopause following IVF treatment, 7Sesh Kamal Sunkara

3 The HIV positive female, 9Joshua U. Klein and Mark V. Sauer

4 The HIV positive male, 13Mark V. Sauer and Joshua U. Klein

5 The hepatitis B/C carrier patient, 17Suzanne P.M. Lutgens, I.H.M. Van Loo, E.C.M. Nelissen and G.A.J. Dunselman

6 The patient with cystic fibrosis, 21Tarek El–Toukhy

7 The patient on medication, 25Arri Coomarasamy

8 The patient with thrombophilia, 29Ying C. Cheong and N.S. Macklon

9 The patient with autoimmune disorders, 34Jos´e Bellver

10 The patient with malignant disease: fertility preservation, 38Arri Coomarasamy

11 The patient with heart disease, 43Natasha Thorogood and Catherine Nelson–Piercy

12 The patient with diabetes, 48Neelam Potdar and Justin C. Konje

13 The patient with thyroid disease, 51Shiao Chan

14 The patient with hyperprolactinemia, 56John Ayuk

15 The patient with polycystic ovaries, 61Adam H. Balen

16 The renal transplant patient and IVF, 65Lynne Robinson and Clara Day

17 The patient with previous pelvic irradiation, 69Vishvanath C. Karande

18 Fertility after chemotherapy, 73Nivedita Reddy

19 The patient with abnormal cervical cytology, 77Mahmood I. Shafi

20 The patient with previous borderline ovarian tumor, 80Arri Coomarasamy and Kavita Singh

21 The patient with an endometrioma, 83Luciano G. Nardo and Oybek Rustamov

22 The patient with cervical stenosis, 86Khaldoun Sharif

23 Vaccination and ART, 90Arri Coomarasamy and Dukaydah van der Berg

24 The patient with hydrosalpinx, 95Annika Strandell

25 The patient with poor ovarian reserve, 99Scott M. Nelson

26 The patient with congenital uterine anomalies, 105Sarah Creighton and Lina Michala

27 The patient with congenital cervico–vaginal anomalies, 109Sarah Creighton and Lina Michala

28 The patient with uterine fibroids, 112Haitham Hamoda and Yakoub Khalaf

29 The patient with previous Essure® sterilization, 115T. Justin Clark

30 The patient with previous endometrial ablation, 119T. Justin Clark

31 The couple with recurrent implantation failure, 124Tarek El–Toukhy

32 The patient with previous uterine artery embolization, 128Haitham Hamoda and Yakoub Khalaf

33 Endometrial polyp detected during ART treatment, 131Arri Coomarasamy

34 The obese patient, 135Mostafa Metwally and Bolarinde Ola

35 Asherman syndrome, 139Dan Yu, Enlan Xia and T.C. Li

36 The older patient, 142William Ledger

37 Requests for mild or natural cycle IVF treatment, 146Brad B. Swelstad and Suheil J. Muasher

38 The ART patient with psychosexual problems, 150Sue Elkin

39 The patient needing third–party reproduction, 153Madhurima Rajkhowa

40 Request for social egg freezing , 159Valerie L. Peddie and Siladitya Bhattacharya

41 The patient with bariatric surgery, 165Zaher O. Merhi and Harry J. Lieman

Section 2: Pituitary suppression and ovarian stimulation phase

42 Poor response during ovarian stimulation, 171Lynne Robinson and Arri Coomarasamy

43 Ovarian stimulation for IVF in a patient with previous severe ovarian hyperstimulation syndrome, 175Khaldoun Sharif

44 Unable to achieve pituitary down–regulation, 178K. Jayaprakasan and Nick Raine–Fenning

45 The patient discovered pregnant during pituitary down–regulation, 184Mohammed Khairy Mahmoud and Arri Coomarasamy

46 Ovarian cysts following pituitary down–regulation, 188Alison Taylor

47 Poor endometrial development, 192Lynne Robinson and Arri Coomarasamy

48 Missed IVF medications, 201Lynne Robinson and Arri Coomarasamy

49 The patient with a history of estrogen–receptor positive cancer, 205Murat So¨nmezer and Kutluk Oktay

50 The patient over–responding to controlled ovarian stimulation during IVF, 208Khaldoun Sharif

Section 3: Oocyte retrieval

51 General anesthesia or sedation for oocyte retrieval?, 215Andrew F. Malins

52 Delayed oocyte retrieval, 219Khaldoun Sharif

53 Empty follicle syndrome, 223George Ndukwe

54 Bleeding following oocyte retrieval, 227Annika K. Ludwig and Barbara Sonntag

55 To flush or not to flush follicles at oocyte retrieval?, 232Micah J. Hill and Eric D. Levens

56 Inaccessible ovaries at oocyte retrieval, 236Hazem Al–Rumaih

57 Endometriotic cysts at oocyte retrieval, 239Graciela Kohls and Juan A. Garc´ a–Velasco

Section 4: Embryo transfer

58 Couple splitting while embryos are in storage, 245Masoud Afnan

59 Endometrial cavity fluid identified during IVF treatment, 249Arri Coomarasamy

60 Difficult embryo transfer, 252Khaldoun Sharif

61 Excessive cervical mucus and retained embryo at embryo transfer, 257Hassan N. Sallam, Ahmed F. Galal and Fady S. Moeity

62 Life after embryo transfer, 261Kelton Tremellen

Section 5: The luteal phase

63 Vaginal bleeding in the luteal phase after IVF, 267Carol Coughlan and Bolarinde Ola

64 Pelvic infection after IVF, 271Muhammad Faisal Aslam

65 The patient presenting with ovarian hyperstimulation syndrome, 274Khaldoun Sharif

66 Adnexal torsion after IVF, 279Saioa Torrealday and Beth W. Rackow

67 Exposure to infection in the luteal phase of IVF, 283Litha Pepas and Arri Coomarasamy

Section 6: The ART laboratory

68 Total failure of fertilization after conventional IVF – rescue ICSI, 291A. Albert Yuzpe

69 Couples not wishing to create surplus embryos in IVF, 296Hossam Mohamed

70 Aneuploidy screening for advanced maternal age or repeated IVF failure, 300Haitham Hamoda and Yacoub Khalaf

71 Choosing an embryo for transfer, 304Denny Sakkas

72 Globozoospermia, 308Steven Mansell, Anne Rice, Catherine Beaton and Christopher L.R. Barratt

73 Total failure of fertilization after ICSI, 313Kaoru Yanagida

74 Refreezing of embryos, 317Jerome H. Check

75 Infection in embryo culture medium, 320Peter M.M. Kastrop

76 ICSI or IVF in nonmale–factor infertility?, 324Mohamed Aboulghar

77 The ART program during a natural or human–made disaster, 328Richard P. Dickey and Carla White

78 Using the wrong sperm or embryos in IVF, 331Khaldoun Sharif and Mutaz Al–Ahmad

Section 7: The male patient

79 Unexpected inability to produce a semen sample on the day of oocyte retrieval, 337Khaldoun Sharif

80 The azoospermic patient, 340Khaldoun Sharif

81 ART in men with Klinefelter syndrome, 344Ronnie G. Fine and Darius A. Paduch

82 ART in men with 100% immotile sperm, 349Carolina Ortega–Hrepich, Dominique Raick and Herman Tournaye

83 Request for posthumous fatherhood with perimortem surgical sperm retrieval, 353Zamip P. Patel, Heather E. Ross and Lawrence S. Ross

84 Retrograde ejaculation and anejaculation, 360Asif Muneer and Anthony Hirsh

85 Sperm retrieval in cancerous testes, 364Saad Aldousari and Armand Zini

86 Leukocytospermia and ART, 367Giuseppe Ricci

87 The infertile male patient with a genetic cause, 371Katherine L. O Flynn O Brien and Ashok Agarwal

88 Y chromosome microdeletions and ART, 376Sherman J. Silber

Section 8: The ART pregnancy

89 Unexpected number or gender of babies after IVF, 383Khaldoun Sharif

90 Suspected ectopic pregnancy after IVF, 387Vishvanath C. Karande

91 Cervical ectopic pregnancy after IVF, 391Usha Verma

92 Heterotopic pregnancy after IVF, 396Abdel–Maguid Ramzy

93 Multi–fetal pregnancy reduction after ART, 400R. Katie Morris and Mark D. Kilby

94 Multiple pregnancy after IVF: to cerclage or not to cerclage? 405Harold Gee

95 Hyperreactio luteinalis after IVF, 409Mohammad Ebrahim Parsanezhad, Leila Forooghinia and Maryam Parsa–Nezhad

96 Lactation by a commissioning mother in surrogacy, 412Frank P. Biervliet and Stephen L. Atkin

Section 9: General issues

97 Dealing with the emotional distress following failed IVF, 417Linda Hammer Burns

98 IVF when the prognosis is very poor or futile, 421Khaldoun Sharif

99 Unexpected drop in the ART clinic pregnancy rate, 425Bulent Urman and Kayhan Yakin

100 Natural fertility after IVF, 430Frank Nawroth and Annika K. Ludwig

Index, 433

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Khaldoun Sharif
Arri Coomarasamy
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