Oral Precancer. Diagnosis and Management of Potentially Malignant Disorders

  • ID: 2222869
  • Book
  • 236 Pages
  • John Wiley and Sons Ltd
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This pioneering book brings together the latest research on precancer conditions of the oral cavity and their specific application to the dental field. In addition to providing a scientific and evidence–based survey of the disparate sources of oral precancer research, this book presents practical information, proposing a rational basis for an interventional clinical management protocol. It will be an invaluable resource for dental practitioners as well as specialists in oral medicine and oral and maxillofacial surgery.

Written and edited by prominent researchers in the field, Oral Precancer furnishes its readers with a balanced approach to this highly topical subject and delivers a concise summary of the current understanding of the nature and behaviour of potentially malignant oral disorders.

KEY FEATURES
Compiles recent research on precancer conditions of the oral cavity
Provides practical information for dentists seeking to apply research in clinical scenarios
Includes reference sections in each chapter listing relevant review articles
Contains a chapter devoted to illustrative case histories
Full of high quality colour clinical photos

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List of Contributors

Preface

Acknowledgements

1. Introduction

General Introduction

Epidemiology

Prevention Treatment Strategies

Terminology

Summary

References

2. Structure and Function of Oral Mucosa

Introduction

Applied Anatomy of the Oral Cavity

Function of the Oral Mucosa

The Microanatomy of Oral Mucosa

Regional Variation of Oral Mucosa

Oral Epithelial Cell Kinetics

Oral Epithelial Cell Proliferative Activity

Anatomical Site Predilection for Oral Carcinogenesis

Summary

References

3. Oral Carcinogenesis

Introduction

Oral Cancer and Precancer

The Progression Model for Oral Cancer

Aetiology and Risk Factors

Patient and Risk Factor Profiling

Summary

References

4. Clinical Presentation of Oral Precancer

Introduction

Clinical Terminology

Precancerous (Premalignant) Lesions

Precancerous (Premalignant) Conditions

Multiple Lesion Disease

Summary

References

5. Diagnostic Methods

Introduction

Screening

Clinical Examination Techniques

Vital Tissue Staining

Light Based Detection Systems

Brush Biopsy and Exfoliative Cytology

Clinical Diagnosis in Practice

Summary

References

6. Pathological Aspects of Oral Precancer

Introduction

Biopsy Techniques

The Role of the Pathologist

Histopathological Features of Oral Potentially Malignant Disorders

Grading of Dysplasia

Limitations in Conventional Pathological Techniques

Summary

References

7. Management of Oral Precancer

Introduction

Risk Factor Modification

Observation versus Intervention

Medical Treatment

Surgical Treatment

Interventional Laser Surgery

Combined Treatment Modalities

Patient Follow Up and Surveillance

Summary

References

8. Clinical Outcome

Introduction

Clinical Outcome Studies

Patient Cohort Studies

Definitions of Clinical Outcome

Newcastle Patient Cohort Studies

Patient Follow Up

Prediction of Clinical Outcome

Summary

References

9. Malignant Transformation and Oral Cancer Development

Introduction

The Risk of Progression to Oral Carcinoma

Malignant Transformation versus Oral Cancer Development

Interventional Laser Surgery and Oral Cancer Prevention

The Newcastle 10 Year Follow Up Study

High and Low Risk Patients

Clinical Signs of Oral Squamous Cell Carcinoma

Diagnosis and Management of Unexpected Malignancy

Prognosis for the Transformed Patient

Summary

References

10. The Future

Introduction

Prevention of Oral Precancer

Early Diagnosis of Potentially Malignant Disease

Interventional Management Strategies in the Future

Individualised Patient Treatments Biomarkers and Targeted Chemoprevention

Future Research Directions

Summary

References

11. Case Histories

Introduction

Diagnosis of Unexpected Malignancy

Multiple Lesion Disease Responding to Conservative Management

Multiple Lesion Disease Requiring Repeated Laser Treatments

Proliferative Verrucous Leukoplakia

Localised Oral Lichenoid Reaction

Multiple Oral Lichenoid Reactions

Widespread Dysplastic Oral Lichenoid Reactions

An Immunosuppressed Patient

Chronic Hyperplastic Candidosis

Tobacco Associated Hyperkeratosis

Malignant Transformation in Longstanding Non–erosive Lichen Planus

Summary

12. Conclusions

Oral Cancer Potentially Malignant Disorders

Clinical Management

Patient Care Pathways

Public Health Strategies

Future Directions

Index

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Peter Thomson
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