The second edition retains the structure of the first, beginning with the basic principles of physiology and then moving into the primary approaches used in pharmacokinetic modeling, including extensive coverage of dosage regimens and adjustments, interspecies extrapolation, experimental design, data collection and analysis, and residues and withdrawal times. With broad human and animal species coverage, Comparative Pharmacokinetics is essential reading for those working in drug research and development, as well as those with advanced interest in pharmacology and toxicology in veterinary or comparative medicine.
- Provides a detailed but understandable reference on the conceptual basis of veterinary and comparative pharmacokinetics
- Covers practical applications to both animal and human medicine
- Offers essential information for ensuring that pharmacokinetics studies are correctly designed and interpreted
- Includes new chapters on quantitative structure permeability relationships and bioequivalence, as well as fully revised and expanded chapters throughout
- Presents a fully rewritten chapter on simultaneous pharmacokinetic–pharmacodynamic modeling to reflect its newly widespread role in comparative medicine
- Facilitates the reader in making conceptual linkages between theory and applications with expanded cross–referencing between topics
2 Principles of Drug Movement in the Body.
3 Quantitative Structure–Permeability Relationships (Xin–Rui Xia).
5 Distribution (with Jennifer Buur).
6 Renal Elimination.
7 Hepatic Biotransformation and Biliary Excretion (Ronald Baynes).
8 Compartmental Models.
9 Noncompartmental Models.
10 Nonlinear Models.
11 Physiological Models (Teresa Leavens).
12 Dosage Regimens.
13 Simultaneous Pharmacokinetic–Pharmacodynamic Modeling (Pierre–Louis Toutain).
14 Study Design and Data Analysis. (Jason Chittenden).
15 Bioequivalence Studies (Marilyn Martinez).
16 Population Pharmacokinetic Models (Jason Chittenden).
17 Dosage Adjustments in Disease States (Jennifer Davis).
18 Interspecies Extrapolations.
19 Tissue Residues and Withdrawal Times (Sharon Mason).