In the last two decades tremendous strides in the field of mechanical support have extended the lives of countless sufferers of congestive heart failure, who total close to 1% of the US population. This technology has saved the lives of patients with acute heart failure due to heart attacks, dilated cardiomyopathies and post–cardiotomy shock and sustained patients with end stage congestive heart failure until a precious donor organ has become available for transplantation. In an attempt to address the growing imbalance between demand and supply of donor hearts, and armed with great hope and excitement, investigators are now examining these devices as potential alternatives to cardiac transplantation.
Cardiac Assist Devices is organised into three main sections, encompassing 30 up–to–date chapters written by the leading authorities in the field. Part I presents an overview of the field of mechanical support, with emphasis placed on the perioperative management of patients requiring mechanical support. New and controversial issues like bridging to recovery, economic impact and immunobiology of assist devices are explored. Part II introduces the currently available devices, focusing on the individual characteristics of the most widely used extracorporeal and intracorporeal ventricular assist devices, including detailed illustrations, implantation techniques, device limitations, and results and outcomes. Part III explores the most promising devices and technologies currently undergoing preclinical evaluation, including the developer′s descriptions and availability forecasts.
This book will be of greatest interest to cardiologists, circulatory physiologists, cardiac anaesthesiologists, critical care physicians, cardiac surgeons, and other healthcare professionals who are challenged daily with the care of patients with acute and chronic heart failure.
Bill Frist, MD.
Part I: General Aspects of Mechanical Support.
1. Clinical Left Heart Assist Devices: A Historical Perspective.
O.H. Frazier, MD, John M. Fuqua, Jr., and David N. Helman, MD.
2. Physiology of Ventricular Interactions During Ventricular Assistance.
David J. Farrar, PhD.
3. Device Selection.
Benjamin C. Sun, MD.
4. Options for Mechanical Support in Pediatric Patients.
Tom R. Karl, MD and Stephen B. Horton, MD.
5. Anesthetic Considerations During Left Ventricular Assist Device Implantation.
Marc L. Dickstein, MD, Berend Mets, MB, ChB, FRCA, PhD, and Mark J.S. Heath, MD.
6. Perioperative Management of Bleeding.
Clifford H. Van Meter, Jr., MD.
7. Management of Perioperative Right–Sided Circulatory Failure.
Jonathan M. Chen, MD and Eric A. Rose, MD.
8. Perioperative Management of Arrhythmias in Recipients of Left Ventricular Assist Devices.
Matthew Williams, MD and James Coromilas, MD.
9. Management of Vasodilatory Hypotension after Left Ventricular Assist Device Placement.
Michael Argenziano, MD and Donald W. Landry, MD, PhD.
10. Left Ventricular Recovery During Left Ventricular Assist Device Support.
Johannes Mueller, MD and Roland Hetzer, MD.
11. Exercise Performance in Patients with Left Ventricular Assist Devices.
Donna Mancini, MD and Ainat Beniaminovitz, MD.
12. Outpatient Support.
Katherine A. Catanese, MSN and David L.S. Morales, MD.
13. Rehabilitation of the Ventricular Assist Device Recipient.
Theresa M. Morrone, MS, PT, C.C.S. and Lori A. Buck, MS, PT, C.C.S.
14. Quality of Life Issues Associated with the Use of Left Ventricular Assist Devices.
Peter A. Shapiro, MD.
15. Economic Considerations of LVAD Implantation.
Alan J. Moskowitz, MD, Deborah L. Williams, MPH, Anita Tierney, MPH, Ronald G. Levitan, BS, Joshua Zivin, PhD, and Annetine C. Gelijns, PhD.
16. Immunobiology of Left Ventricular Assist Devices.
Jan–Hendrik Ankersmit, MD and Silviu Itescu, MD.
Part II: Available Devices:.
A. Extracorporeal Devices.
17. Extracorporeal Support: Centrifugal Pumps.
Jack J. Curtis, MD and Colette Wagner–Mann, DVM, PhD.
18. Extracorporeal Support: The ABIOMED BVS 5000.
G. Kimble Jett, MD and Robert R. Lazzara, MD.
19. Extracorporeal Support: The Thoratec Device.
D. Glenn Pennington, MD, Timothy E. Oaks, MD, and Douglas P. Lohmann, M.Eng..
20. Extracorporeal Membrane Oxygenation in Adults.
Richard J. Kaplon, MD and Nicholas G. Smedira, MD.
21. Extracorporeal Support: The Berlin Heart.
Matthias Loebe, MD, PhD, Friedrich Kaufmann, and Roland Hetzer, MD, PhD.
Part II: Available Devices:.
B. Intracorporeal Devices.
22. Intracorporeal Support: The Intra–aortic Balloon Pump.
David N. Helman, MD and Gus J. Vlahakes, MD.
23. Intracorporeal Support: Thermo Cardiosystems Ventricular Assist.
Daniel J. Goldstein, MD.
24. Intracorporeal Support: Novacor Left Ventricular Assist System.
Naraynan Ramasamy, PhD, Rita L. Vargo, MSN, RN, Robert L. Kormos, MD, and Peer M. Portner, Phd.
25. Intracorporeal Support: Cardiowest Total Artificial Heart.
Jack Copeland, MD, Francisco Arabia, MD, Richard Smith, MSEE, and Paul Nolan, PhDPart III: Future Devices.
26. Axial Flow Pumps.
Joseph J. DeRose, Jr., MD and Robert K. Jarvik, MD.
27. The DeBakey Ventricular Assist Device.
George P. Noon, MD, Deborah Morley, PhD, Suellen Irwin, RN, and Michael E. DeBakey, MD.
28. Epicardial Compression Mechanical Devices.
John H. Artrip, MD and Daniel Burkhoff, MD, PhD.
29. The Pennsylvania State University Totally Implantable LVAD and Total Artificial Heart.
Sanjay M. Mehta, MD and Walter E. Pae, Jr., MD.
30. The HeartSaver VAD: A Fully Implantable VAD for Long–Term Support.
Tofy Mussivand, Paul J. Hendry, Roy G. Masters, and Wilbert J. Keon