This book is among the first to give a comprehensive overview of the promising and rapidly growing field of computer modeling of the heart. The success of this new field strongly depends on the establishment of multidisciplinary exchanges of information. Accordingly, scientists from different horizons, including clinicians, basic electrophysiologists, engineers, and mathematicians, have all contributed to this succinct work.
The book′s aim is to show how computer modeling can help us to understand the mechanisms of cardiac arrhythmia and to develop new therapeutic strategies. In addition to computer simulation results, it presents the corresponding experimental data, efficiently gathering in one book research work on simulation and experiments on humans and animals.
Electrophysiologists, cardiologists, biomedical engineers, biophysicists, and others interested in the field of computer modeling of cardiac electrophysiology, will all benefit from this current, dynamic review.
Nathalie Virag, Olivier Blanc, Lukas Kappenberger.
Part I. Electrical Mapping and Modeling of Atria.
Chapter 1. Ten Years of Mapping Atrial Fibrillation.
Natasja M.S. de Groot, Maurits Allessie, MD, PhD.
Chapter 2. The Role of Deteriorated Inferoposterior Interatrial Conduction in Atrial Fibrillation.
S. Bertil Olsson, MD, PhD.
Chapter 3. Simulation of Arrhythmias in a Computer Model of Human Atria.
Olivier Blanc, MS, Nathalie Virag, PhD, Andre Nicoulin, PhD, Vincent Jacquemet, MS, Jean–Marc Vesin, PhD, Lukas Kappenberger, MD.
Chapter 4. A Realistic and Efficient Model of Excitation Propagation in the Human Atria.
Christian W. Zemlin, MS, Hanspeter Herzel, PhD, Siew Y. Ho, PhD, FRCPath, Alexandre Panfilov, PhD.
Part II. Electrical Mapping and Modeling of Ventricles.
Chapter 5. Noninvasive Electrocardiographic Imaging of Cardiac Excitation and Arrhythmia.
Yoram Rudy, PhD.
Chapter 6. Spatial Gradients in Activation Frequency: A Mechanism of Stable Ventricular Fibrillation.
José Jalife, MD, Faramarz H. Samie, PhD, Jacques Beaumont, PhD.
Chapter 7. Ventricular Excitation: Wavefronts, Electrograms and Potential Patterns.
Piero Colli–Franzone, PhD.
Chapter 8. Three–Dimensional Organization of Reentry in Fibrillating Ventricular Wall.
Arkady M. Pertsov, PhD.
Chapter 9. Action Potential Duration Alternans in a Mono–Cellular Model based on Beeler–Reuter Kinetics.
Etienne Pruvot, MD, Vincent Jacquemet, MS, Jean–Marc Vesin, PhD, Nathalie Virag, PhD, Olivier Blanc, MS, Jacques Koerfer, MD, Martin Fromer, MD, Lukas Kappenberger, MD.
Part III. Mechanical Modeling.
Chapter 10. Measurement of Ventricular and Atrial Wall Motion using Magnetic Resonance with Spin–Tagging.
Elliot McVeigh, PhD.
Chapter 11. Computational and Experimental Modeling of Ventricular Electromechanical Interactions.
Andrew McCulloch, PhD, Derrick Sung, MS, Mary Ellen Thomas, MS, Anushka Michailova, MS.
Part IV. Towards Whole Heart Modeling.
Chapter 12. Simulation of Cardiac Electrophysiology and Electrocardiography.
Frank B. Sachse, PhD, Christian Werner, MS, Gunnar Seeman, MS.
Chapter 13. Modeling of Arbitrary 3D Geometries: Application to the Atria and Ventricles.
David M. Harrild, PhD, Craig S. Henriquez, PhD.
Chapter 14. Auckland Whole Heart Model: An Integrated Computational Framework for the Construction of a Whole Organ Model of Cardiac Function.
Nicolas P. Smith, PhD, Peter J. Mulquiney, PhD, Denis Noble, PhD, Peter J. Hunter, PhD.
Part V. Options in the Treatment of Atrial Fibrillation.
Chapter 15. Mechanisms of Atrial Fibrillation.
Albert L. Waldo, MD.
Chapter 16. A Computer Model to Test Therapeutic Interventions for Atrial Fibrillation.
Nathalie Virag, PhD, Olivier Blanc, MS, Olaf Eick, MS, Jean–Marc Vesin, PhD, Lukas Kappenberger, MD.
Chapter 17. Atrial Fibrillation: A Clinician′s Standpoint.
Martin Fromer, MD.
Part VI. Options in the Treatment of Ventricular Fibrillation.
Chapter 18. Mechanisms of Ventricular Defibrillation.
Nipon Chattipakorn, MD, PhD, Raymond Ideker, MD, PhD.
Chapter 19. Induction of Reentry and Defibrillation: The Role of Virtual Electrodes.
Natalia Trayanova, PhD.
Chapter 20. Virtual Electrode Hypothesis of Stimulation of the Heart.
Igor R. Efimov, PhD.
Part VII. Discussion: Can Computer Simulations be Useful for the Development of New Therapeutic Strategies?.
Chapter 21. Arrhythmia: a Therapeutic Dilemma – Lukas Kappenberger, MD.