The lungs accommodate the entire cardiac output, and the pulmonary vessels are well known for their metabolic and endocrine functions, as well as gas exchange. The interaction of the pulmonary circulation with the cellular elements of blood has received less attention. Interactions of Blood and the Pulmonary Circulation covers many topics of interest to the clinician. In particular, chapters on sickle cell anemia provide a wealth of information on mechanisms of vascular occlusion, suggesting new approaches to treatment for the cardiologist and the pulmonary and intensive care physician. Intensivists will also enjoy the chapters on the role of leukocytes and inflammation in lung injury, and those on the contribution of platelets and thrombosis in pulmonary hypertension. The long–term management of chronic thromboembolic pulmonary hypertension is covered in detail.
SECTION I. Introduction.
Chapter 1. The Development of Concepts of the Interaction of Blood and the Pulmonary Circulation. (Deborah A. Quinn and Charles A. Hales).
SECTION II. Erythrocytes.
Chapter 2. The Endothelium in Sickle Cell Disease. (Robert P. Hebbel).
Chapter 3. Thrombin, Endothelial Gap Formation, and Erythrocyte Adhesion. (Stephen H. Embury and Neil M. Matsui.
Chapter 4. Adhesion of Sickle Erythrocytes to Extracellular Matrix. (Cheryl A. Hillery).
Chapter 5. Mechanisms of Monocyte Migration Following Sickle Erythrocyte Adherence to Endothelium (Vijay K. Kalra, Suresh Selvaraj, and Caage Johnson).
Chapter 6. Inflammation Causing Adhesion of Sickle Erythrocytes to Endothelium. (Timothy M. Wick).
Chapter 7. Phospholipids Products from Activated Polymorphonuclear Cells: Potential role in Sickle Red Blood Cell Microvascular Occlusion. (Johnson Hayes, Jr., and Boniface Obiako).
Chapter 8. Potential New Approaches to the Treatment of Sickle Cell Disease. (John V. Weil and Peter A. Lane).
Chapter 9. Red Blood Cell–Derived ATP Is a Determinant of Nitric Oxide Synthesis in the Pulmonary Circulation. (Randy S. Sprague, Mary L. Ellsworth, Alan H. Stephenson, and Andrew J. Lonigro).
Chapter 10. Malaria and the Microcirculation. (May Ho).
SECTION III. Platelets.
Chapter 11. The Role of Platelets in Pulmonary Hypertension. (Andrew J. Peacock, Paul Egermayer , and G. Ian Town).
Chapter 12. Emerging Concepts of the Mechanism of Platelet Secretion. (Guy L. Reed).
Chapter 13. Platelet Activation: Communication with Integrin Cytoplasmic Domains. (Leslie V. Parise).
Chapter 14. Control of Platelet Reactivity by Endothelial Ecto–ADPase/CD39:Signifcance for Occlusive Vascular Diseases.(Aaron J. Marcus, M. Johan Broekman, Joan H.F. Drosopoulos, Naxiba Islam, Richard B. Gayule, David J. Pinsky, and Charles R. Maliszewski).
SECTION IV. Leukocytes.
Chapter 15. Neutrophil Degranulation: Mechanism of Regulation and Dysregulation in Interactions with Endothelial Cells. (Tadaatsu Imaaizumi, Matthew K. Topham, Thoams M. McIntyre, Stephen M. Prescott, and Guy A. Zimmerman).
Chapter 16. Leukocyte Adhesion and Emigration in the Lung. (S. Badley Forlow, C. Edward Rose, and Klaus Ley.
Chapter 17. In Vitro Regulation of Leukocyte Diiapedesis by the Endothelial Cell Contractile Apparatus. (Keri N. Jacobs, Irina Petrache, and Joe G. N. Garcia).
Chapter 18. Neutrophil Sequestration and Migration in Lung Microvessels: Influence of Neutrophil Heterogeneity. (Stephan F. van Eeden).
Chapter 19. leukocyte and Erythrocyte Kinetics in the Pulmonary Microcirculation. (Wiltz W. Wagner, Jr).
SECTION V. Thrombosis.
Chapter 20. Coagulation adn Fibrinolytic Factors in Pulmonary Hypertnesion. (Carolyn H. Welsh).
Chapter 21. Molecular Approaches to Identify Mechanism of Thrombus Stabilization in the Pulmonary Vasculature. (Elisabeth Gharehbaghi–Schnell and Irene M. Lang).
Chapter 22. Hypoxia–Induced Activation of Early Growth Response (Egr)–1: A Novel Pathway Mediating the Vascular Response to Oxygen Deprivation (Shi Fang Yan, David J. Pinsky, adn David M. Stern).
Chapter 23. Long–Term Sequelae Following Pulmonary Thromboendarterectomy. (William R. Auger).