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Tuberous Sclerosis Complex. From Basic Science to Clinical Phenotypes. Edition No. 1. International Review of Child Neurology

  • ID: 2224219
  • Book
  • January 2003
  • Region: Global
  • 328 Pages
  • John Wiley and Sons Ltd
"This is clearly the most authoritative and contemporary statement of current knowledge yet published."
from the Foreword by H. Sarnat

Tuberous sclerosis is the prototype of a category of malformations uniquely characterized by disturbances in cellular differentiation and growth. It presents with a complex association of different neurological phenotypes, including seizures, cognitive impairments and autism. It is important not only because it is a relatively common hereditary neurological disease with high morbidity, but because it has implications in other pathological processes, such as dysplasia and neoplasia, hamartoma formation and other disturbances in morphogenic processes.

This book correlates new genetic data and basic science, covers clinical presentation, reviews the historical background and current diagnostic criteria, and deals with the recent advances in neuropathology, molecular genetics and neurobiology which give a better understanding of the pathogenesis of the disease.

Paediatricians and child neurologists will find this book uniquely useful.

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Index.

Foreword by H. Sarnat.

Preface

  1. Historical background, Paolo Curatolo
  2. Diagnostic criteria, Paolo Curatolo
  3. Neurological manifestations, Paolo Curatolo and Magda Verdecchia
  4. Seizures, Paolo Curatolo and Stefano Seri
  5. Intellectual and cognitive impairments, Patrick F. Bolton
  6. Autism, Michael Dowling and Paolo Curatolo
  7. Neuroimaging, Alessandro Bozzao, Guglielmo Manenti and Paolo Curatolo
  8. Positron emission tomography, Eishi Asano, Diane C. Chugani and Harry T. Chugani
  9. Dermatologic and stomatologic manifestations, Sergiusz Jozwiak and Robert Schwartz
  10. Ophthalmologic manifestations, Sergiusz Jozwiak
  11. Renal involvement, Sergiusz Jozwiak
  12. Cardiac and vascular involvement, Sergiusz Jozwiak
  13. Hepatic, lung, splenic and pancreatic involvement, Sergiusz Jozwiak and Paolo Curatolo
  14. Molecular genetics, David J. Kwiatkowski, Mary Pat Reeve, Jeremy P. Cheadle and Julian R. Sampson
  15. Neuropathology, Masashi Mizuguchi and Okio Hino
  16. Molecular neurobiology, Peter B. Crino
  17. Future directions, Paolo Curatolo
Note: Product cover images may vary from those shown
Paolo Curatolo
Note: Product cover images may vary from those shown
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