This volume's primary goal is to provide a comprehensive understanding of recent developments and advancements in the study of ataxic disorders. Beginning with an examination of the cerebellar region, and then progressing to a fresh perspective on the clinical aspects of the various forms of ataxia, this handbook gives clinicians a state-of-the-art reference for the management of the many etiologies and neurological manifestations of ataxic disorders.
Clinicians will gain a broader understanding of generative ataxias and the genetic disorders associated with them. In addition, new neurophysiological and imaging techniques are discussed, along with an in-depth examination of the treatment and management protocols of ataxic diseases.
- A volume in the Handbook of Clinical Neurology series, which has an unparalleled reputation as the world's most comprehensive source of information in neurology
- International list of contributors including the leading workers in the field
- Describes the advances which have occurred in clinical neurology and the neurosciences, their impact on the understanding of neurological disorders and on patient care
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BASIC ASPECTS The cerebellum
structure and connections; Physiology of clinical dysfunction of the cerebellum; Oculomotor aspects of the hereditary cerebellar ataxias; Magnetic resonance and nuclear medicine imaging studies in ataxic disease; Neuropathology of degenerative ataxias; Approach to ataxic diseases
ACQUIRED ATAXIAS Acquired ataxias, infectious and para-infectious; Ataxia in patients with brain infarcts and hemorrhages; Ataxia resulting from posterior fossa tumors of childhood and other mass lesions; Nutritional cerebellar degeneration, with comments on its relationship to Wernicke disease and alcoholism; Immune-mediated acquired ataxias; Toxic agents causing cerebellar ataxias; Paraneoplastic cerebellar degeneration
DEGENERATIVE ATAXIAS Epidemiology and population genetics of degenerative ataxias; Sporadic adult onset ataxia of unknown aetiology
MITOCHONDRIAL, AUTOSOMAL RECESSIVE AND X-LINKED Overview of autosomal recessive ataxias; Friedrich's ataxia; Ataxia with vitamin E deficiency and abetalipoproteinemia; Ataxia-telangiectasia; Autosomal recessive cerebellar ataxias with oculomotor apraxia; Other autosomal recessive and childhood ataxias; Ataxia in mitochondrial disorders; Fragile X-associated tremor/ataxia syndrome
AUTOSOMAL DOMINANT Overview of autosomal dominant ataxias; Spinocerebellar ataxia type 1, 2; Machado-Joseph disease/spinocerebellar ataxia type 3; Spinocerebellar ataxia type 5, 6, 7; Clinical and genetic features of spinocerebellar ataxia type 8; Spinocerebellar ataxia type 10, 11, 12, 13, 14, 15, 20, 25, 28; Other spinocerebellar ataxias; Dentatorubral-pallidoluysian atrophy; Episodic ataxias 1 and 2
OTHER ISSUES Ataxias related to sensory neuropathies; Frontal lobe ataxia; Balance and gait problems in the elderly; Treatment and management issues in ataxic disease