- Test Your Problem–Solving Skills feature shows students how to approach and solve a key problem. In addition, a Solve It icon prompts students to go online to work with animated tutorials. Practice problems for all question types are found at the end of each chapter.
- The Focus On boxes (one per chapter) have been revised to include the most current developments in genetics as well as the most relevant topics to students.
- A streamlined topical coverage, vetted by a panel of genetics instructors, makes for a text that is manageable in size. This textbook will provide instructors and students with in–depth explanations of key topics frequently covered in a one–semester course.
- Animated solutions to the Solve It prompts in the text utilize Camastia Studio software, a registered trademark of TechSmith Corporation. There tutorials provide step–by–step solutions that appear as if they are written out by hand as an instructor voice–over explains each step.
- GO Problem tutorials help students build confidence as they observe a problem being worked out and then attempt to solve a similar problem on their own.
The Personal Genome.
Three Great Milestones In Genetics.
DNA As The Genetic Material.
Genetics And Evolution.
Levels Of Genetic Analysis.
Genetics In The World: Applications Of Genetics To Human Endeavors.
Chapter 2. Cellular Reproduction.
Cells And Chromosomes.
Life Cycles Of Some Model Genetic Organisms.
Chapter 3 Mendelism: The Basic Principles Of Inheritance.
Mendel′s Study Of Heredity.
Applications Of Mendel′s Principles.
Testing Genetic Hypotheses.
Mendelian Principles In Human Genetics.
Chapter 4 Extensions Of Mendelism.
Allelic Variation And Gene Function.
Gene Action: From Genotype To Phenotype.
Inbreeding: Another Look At Pedigrees.
Chapter 5 The Chromosomal Basis Of Mendelism.
The Chromosome Theory Of Heredity.
Sex–Linked Genes In Humans.
Sex Chromosomes And Sex Determination.
Dosage Compensation Of X–Linked Genes.
Chapter 6 Variation In Chromosome Number And Structure.
Rearrangements Of Chromosome Structure.
Chapter 7 Linkage, Crossing Over, And Chromosome Mapping In Eukaryotes.
Linkage Analysis In Humans.
Recombination And Evolution.
Chapter 8 The Genetics Of Bacteria And Their Viruses.
Multi–Drug–Resistant Bacteria: A Ticking Timebomb?
Viruses And Bacteria In Genetics.
The Genetics Of Viruses.
The Genetics Of Bacteria.
Mechanisms Of Genetic Exchange In Bacteria.
The Evolutionary Significance Of Genetic Exchange In Bacteria.
Chapter 9 DNA And The Molecular Structure Of Chromosomes.
Functions Of The Genetic Material.
Proof That Genetic Information Is Stored In DNA.
Proof That RNA Stores The Genetic Information In Some Viruses.
Chromosome Structure In Prokaryotes And Viruses.
Chromosome Structure In Eukaryotes.
Chapter 10 Replication Of DNA And Chromosomes.
Basic Features Of DNA Replication In Vivo.
DNA Replication In Prokaryotes.
Unique Aspects Of Eukaryotic Chromosome Replication.
Chapter 11 Transcription And RNA Processing.
Transfer Of Genetic Information: The Central Dogma.
The Process Of Gene Expression.
Transcription In Prokaryotes.
Transcription And RNA Processing In Eukaryotes.
Interrupted Genes In Eukaryotes: Exons And Introns.
Removal Of Intron Sequences By RNA Splicing.
Chapter 12 Translation and the Genetic Code
One Gene One Colinear Polypeptide
Protein Synthesis: Translation
The Genetic Code
Chapter 13 Mutation, DNA Repair, and Recombination
Mutation: Source of the Genetic Variability Required for Evolution
The Molecular Basis of Mutation
Mutation: Basic Features of the Process
Mutation: Phenotypic Effects
Assigning Mutations to Genes by the Complementation Test
Screening Chemicals for Mutagenicity: The Ames Test
DNA Repair Mechanisms
Inherited Human Diseases with Defects in DNA Repair
DNA Recombination Mechanisms
Chapter 14 The Techniques of Molecular Genetics
Basic Techniques Used to Identify, Amplify, and Clone Genes
Construction and Screening of DNA Libraries
The Molecular Analysis of DNA, RNA, and Protein
The Molecular Analysis of Genes and Chromosomes
Chapter 15 Genomics
Genomics: An Overview
Correlated Genetic, Cytological, and Physical Maps of Chromosomes
Map Position–Based Cloning of Genes
The Human Genome Project
RNA and Protein Assays of Genome Function
Chapter 16 Applications of Molecular Genetics
Use of Recombinant DNA Technology to Identify Human Genes and Diagnose Human Diseases
Molecular Diagnosis of Human Diseases
Human Gene Therapy
Production of Eukaryotic Proteins in Bacteria
Transgenic Plants and Animals
Reverse Genetics: Dissecting Biological Processes by Inhibiting Gene Expression
Chapter 17 Transposable Genetic Elements
Transposable Elements: An Overview
Transposable Elements in Bacteria
Cut–and–Paste Transposons in Eukaryotes
Retroviruses and Retrotransposons
Transposable Elements in Humans
The Genetic and Evolutionary Significance of Transposable Elements
Chapter 18 Regulation of Gene Expression in Prokaryotes
Constitutive, Inducible, and Repressible Gene Expression
Positive and Negative Control of Gene Expression
Operons: Coordinately Regulated Units of Gene Expression
The Lactose Operon in E. coli: Induction and Catabolite Repression
The Tryptophan Operon in E. coli: Repression and Attenuation
Translational Control of Gene Expression
Posttranslational Regulatory Mechanisms
Chapter 19 Regulation of Gene Expression in Eukaryotes
Ways of Regulating Eukaryotic Gene Expression: An Overview
Induction of Transcriptional Activity by Environmental and Biological Factors
Molecular Control of Transcription in Eukaryotes
Posttranscriptional Regulation of Gene Expression by RNA Interference
Gene Expression and Chromatin Organization
Activation and Inactivation of Whole Chromosomes
Chapter 20 The Genetic Control of Animal Development
A Genetic Perspective on Development
Maternal Gene Activity in Development
Genetic Analysis of Development in Vertebrates
Chapter 21 The Genetic Basis of Cancer
Cancer: A Genetic Disease
Tumor Suppressor Genes
Genetic Pathways to Cancer
Chapter 22 Inheritance of Complex Traits
Statistics of Quantitative Genetics
Analysis of Quantitative Traits
Correlations Between Relatives
Quantitative Genetics of Human Behavioral Traits
Chapter 23 Population Genetics
The Theory of Allele Frequencies
Random Genetic Drift
Populations in Genetic Equilibrium
Chapter 24 Evolutionary Genetics
The Emergence of Evolutionary Theory
Genetic Variation in Natural Populations
Appendix A: The Rules of Probability
Appendix B: Binomial Probabilities
Appendix C: In Situ Hybridization
Appendix D: Evidence for an Unstable Messenger RNA
Appendix E: Evolutionary Rates
Answers to Odd–Numbered Questions and Problems
Michael J. Simmons is a Professor in the Department of Genetics, Cell Biology and Development at the University of Minnesota, Twin Cities. He received his B.A. degree in biology from St. Vincent College in Latrobe, Pennsylvania, and his M.S. and Ph.D. degrees in genetics from the University of Wisconsin, Madison. Dr. Simmons has taught a variety of courses, including genetics and population genetics. He has also mentored many students on research projects in his laboratory. Early in his career he received the Morse–Amoco teaching award from the University of Minnesota in recognition of his contributions to undergraduate education. Dr. Simmons s research focuses on the genetic significance of transposable elements in the genome of Drosophila melanogaster. He has served on advisory committees at the National Institutes of Health and was a member of the Editorial Board of the journal Genetics for 21 years. One of his favorite activities, figure skating, is especially compatible with the Minnesota climate.