Fundamentals of Molecular Virology. 2nd Edition

  • ID: 2241058
  • Book
  • 528 Pages
  • John Wiley and Sons Ltd
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  • Clear style. Written in a simple and clear style for students with a background in cell and molecular biology.
  • Full–color figures. Numerous full–color figures complement the text and illustrate virus structure, genome organization, and individual steps in virus replication.
  • Extended coverage. This second edition has five new chapters: Cucumber Mosaic Virus; Viruses of Archaea; Viruses of Algae and the giant Mimivirus; Intrinsic Cellular Responses Against Virus Infection; and Innate and Adaptive Immune Responses to Virus Infection. All other chapters have been revised and updated.
  • Study aids include thumbnail sketches of each virus group, informative chapter subheadings, and a comprehensive glossary with definitions of numerous terms.
  • Chapter introductions give historical background and information about viral diseases.
  • Text boxes throughout the book feature exciting and current developments in molecular virology or practical applications of viruses in science and medicine.
  • Key Terms, Fundamental Concepts, and Review Questions at the end of each chapter help students review and organize information they have learned.
  • Information on human pathogens. Includes chapters on important human pathogens including herpes viruses, hepatitis B and C viruses, human immunodeficiency virus, influenza viruses, measles virus, poliovirus, smallpox virus, West Nile virus, and others.
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Section I: Introduction to Virology

1. Introduction to Virology 2Nicholas H. Acheson

2. Virus Structure and Assembly 18Stephen C. Harrison

3. Virus Classification: The World of Viruses 31Nicholas H. Acheson

4. Virus Entry 45Ari Helenius

Section II: Viruses of Bacteria and Archaea

5. Single–Stranded RNA Bacteriophages 59Jan van Duin

6. Microviruses 69Bentley Fane

7. Bacteriophage T7 77William C. Summers

8. Bacteriophage Lambda 85Michael Feiss

9. Viruses of Archaea 97David Prangishvili

Section III: Positive–Strand RNA Viruses of Eukaryotes

10. Cucumber Mosaic Virus 112Ping Xu, Marilyn J. Roosinck

11. Picornaviruses 125Bert L. Semler

12. Flaviviruses 137Richard Kuhn

13. Togaviruses 148Milton Schlesinger, Sondra Schlesinger, Richard Kuhn

14. Coronaviruses 159Mark Denison, Michelle M. Becker

Section IV: Negative–Strand and Double–Stranded RNA Viruses of Eukaryotes

15. Paramyxoviruses and Rhabdoviruses 175Nicholas H. Acheson, Daniel Kolakofsky, Christopher Richardson, Laurent Roux

16. Filovirouses 188Heinz Feldman, Hans–Dieter Klenk, Nicholas H. Acheson

17. Bunyaviruses 200Richard M. Elliott

18. Influenza Viruses 225Terence S. Dermody, James D. Chappell

19. Reoviruses 225Terence S. Dermody, James D. Chappell

Section V: Small DNA Viruses of Eukaryotes

20. Parvoviruses 238Peter Beard

21. Polyomaviruses 247Nicholas H. Acheson

22. Papillomaviruses 263Greg Matlashewski, Lawrence Banks

Section VI: Larger DNA Viruses of Eukaryotes

23. Adenoviruses 274Philip Branton

24. Herpesviruses 285Bernard Roisman, Gabriella Campadelli–Fiume, Richard Longnecker

25. Baculoviruses 302Eric B. Carstens

26. Poxviruses 312Richard C. Condit

27. Viruses of Algae and Mimivirus 325Michael J. Allen, William H. Wilson

Section VII: Viruses That Use A Reverse Transcriptase

28. Retroviruses 342Alan Cochrane

29. Human Immunodeficiency VirusAlan Cochrane

30. Hepadnaviruses 365Christopher Richardson

Section VIII: Viroids and Prions

31. Viroids and Hepatitis Delta Virus 378Jean–Pierre Perreault, Martin Pelchat

32. Prions 387Dalius J. Briedis

Section IX: Host Defenses Against Virus Infection

33. Intrinsic Cellular Defenses Against Virus Infection 398Karen Mossman, Pierre Geninm, John Hiscott

34. Innate and Adaptive Immune Responses to Virus Infection 415Malcolm G. Baines, Karen Mossman

Section X: Antiviral Agents and Virus Vectors

35. Antiviral Vaccines 428Brian Ward

36. Antiviral ChemotherapyDonald M. Coen

37. Eukaryotic Virus Vectors 456





Rénald Gilbert, Bernard Massie

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I like the overall organization and directness in the writing. The chapter outlines that cover the basic features of the virus discussed are quite useful. The illustrations are clear and easy to interpret.Michael Graves, University of Massachusetts Lowell

Having each chapter that covers a specific virus written by an expert in the field then having Acheson bring the material into a common style is an excellent approach. I enjoy the slight stylistic differences that I find in the chapters, but Acheson has a direct and concise approach that makes the information throughout the text understandable for students. Chapters are short and direct. The table of contents is informative. Sections within the chapters are logically organized and headings are informative. The boxes provide interesting side topics in an extremely concise manner. Overall, I find Acheson to be an excellent text. William Tapprich, University of Nebraska Omaha

The conceptual approach to virus biology is the greatest strength of the text. The book has the appropriate level of molecular detail and it is presented in a manner that an undergraduate can readily grasp. It is a highly readable text. Sharon Roberts, Auburn University

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