This fifth edition has undergone major restructuring, with some sections totally rewritten; it is now more logically organised and substantially more user–friendly (with the addition of ′summary boxes′ throughout the text) to incorporate the new statistical techniques and approaches that have made an appearance in the last nine years since the last edition. Also, some chapters or chapter headings are specifically marked to signify material that is generally a little more difficult than the material in which it is embedded – such sections or chapters can be omitted at first reading.
Several new chapters have been added – "Associations: Chance, Confounded and Causal?" explaining without any formulae the concepts underlying confounding, confidence intervals and p values, and the interpretation of associations observed in research investigations. The other new chapter considers sample size calculations in some detail and provides, in addition to the relevant formulae, useful tables which should give the researcher an indication of the order of magnitude of the number of subjects he or she might require in different situations.
2. Probability, Populations and Samples.
3. Associations: Chance, Confounded or Causal?.
4. Confidence intervals: General principles; Proportions, Means, Medians, Counts and Rates.
5. Hypothesis Testing: General Principles and One–sample Tests for Means, Proportions, Counts and Rates.
6. Epidemiological and Clinical Research Methods.
7. Confidence intervals and Hypothesis Tests: Two–group Comparisons.
8. Sample Size Determination.
9. Comparison of More than Two Independent Groups.
10. Associations between Two Quantitative Variables: Regression and Correlation.
11. Multivariate Analysis and the Control of Confounding!.
12. Bias and Measurement Error.
Appendix A Computational Shortcuts.
Appendix B Statistical Tables.
Appendix C A "Cookbook" of Hypothesis Tests and Confidence Intervals.
Appendix D World Medical Association Declaration of Helsinki
...the book can be warmly recommended as a textbook and reference for undergraduate medical students and health professionals." Statistical Methods in Medical Research (on the fourth edition)
"It should prove useful for both undergraduate medical and paramedical students, and for postgraduate researchers and clinicians who wish to have a greater understanding of medical statistics or to analyse their own data." Modern Medicine of Australia (on the fourth edition)