Disorders of Neuronal Migration. International Child Neurology Association

  • ID: 2250377
  • Book
  • Region: Global
  • 220 Pages
  • John Wiley and Sons Ltd
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Neuronal migration is a unique process during the development of brain structure. Although cerebral anomalies resulting from impaired migration have been identified for nearly a century, most of our knowledge has accumulated in the last decade. Disorders of neuronal migration are causes of mental handicap, autism, and epilepsy. Many are genetically determined and need precise diagnosis to provide genetic counselling.

This book addresses the various aspects of neuronal migration disorders in an ordered way. It will help the clinician to acquire insight as well as proficiency in diagnosis. Individual chapters describe subgroups including lissencephalies, subependymal heterotopia, non–lissencephalic cortical dysplasias, anomalies of the corpus callosum, hemimegalencephaly, schizencephaly, polymicrogyria and multisystem disorders with impaired migration such as chromosomal and metabolic syndromes. Neuroradiological and genetic data are provided with the respective chapters.

Although the book is intended for clinical practice, it provides core information for all interested in this important biological process.

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Introduction, Peter G. Barth

Morphogenesis of the human cerebral cortex, V. S. Caviness Jr, T. Takahashi, R. S. Nowakowski and Robert Wood

Lissencephaly: the clinical and molecular genetic basis of diffuse malformations of neuronal migration, William B. Dobyns and Richard J. Leventer

Non–lissencephalic cortical dysplasias, Ruben I. Kuzniecky and Frederick Andermann

Periventricular gray matter heterotopia: a heterogenous group of malformations of cortical development, Richard J. Leventer and William B. Dobyns

Anomalies of the Corpus Callosum and cortical malformations, A. James Barkovich

Hemimegalencephaly, Laura Flores–Sarnat
.

Index
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"I found this to be a very worthwhile book which provides an excellent overview of a challenging and increasingly important area of pediatric neurology."
Developmental Medicine & Child Neurology

"This book is going to be a text of reference for neurologists and epileptologists no mater how many updated classifications of malformations of cortical development may arise." Infant & Child Development

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