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G Protein Coupled Receptors, Vol 521. Methods in Enzymology

  • ID: 2252738
  • Book
  • March 2013
  • 480 Pages
  • Elsevier Science and Technology
This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. This volume covers G protein coupled receptors and includes chapters on such topics as G protein-coupled receptor trafficking motifs, structure-based virtual screening, and automation-friendly high throughput assays for identification of pharmacoperone drugs.

- Continues the legacy of this premier serial with quality chapters authored by leaders in the field - Covers G protein coupled receptors- Contains chapters on such topics as G protein-coupled receptor trafficking motifs, structure-based virtual screening, and automation-friendly high-throughput assays for identifying pharmacoperone drugs

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GPCR Trafficking

- Therapeutic Rescue of Misfolded/Mistrafficked Mutants: Automation-Friendly High Throughput Assays for Identification of Pharmacoperone Drugs of GPCRs - Trafficking of the Follitropin Receptor - Single Molecule Imaging Technique to Study the Dynamic Regulation of GPCR Function at the Plasma Membrane - GPCR Oligomerization and Receptor Trafficking - b-Arrestins and G Protein-Coupled Receptor Trafficking - Tracking Cell Surface Mobility of GPCRs Using ?-Bungarotoxin Linked Fluorophores - Regulatory Mechanism of G Protein-Coupled Receptor Trafficking to the Plasma Membrane: A Role for mRNA Localization - Dissecting Trafficking and Signaling of Atypical Chemokine Receptors

Trafficking Motifs

- Systematic and Quantitative Analysis of G Protein-Coupled Receptor Trafficking Motifs - Identification of Endoplasmic Reticulum Export Motifs for G Protein-Coupled Receptors - Amino Acid Residues of G-Protein Coupled Receptors Critical for Endoplasmic Reticulum Export and Trafficking

GPCR Oligomerization

- G Protein-Coupled Heteromers Regulation in Disease - Hetero-Oligomerization and Specificity Changes of G Protein-Coupled Purinergic Receptors: Novel Insight into Diversification of Signal Transduction - Bimolecular Fluorescence Complementation Analysis of G Protein-Coupled Receptor Dimerization in Living Cells - G-Protein Coupled Receptor Heterodimerization in the Brain - Experimental Strategies for Studying G Protein-Coupled Receptor Homo- and Heteromerization with Radioligand Binding and Signal Transduction Methods - Analysis of GPCRs Dimerization Using Acceptor Photobleaching Resonance Energy Transfer Techniques - Techniques for the Discovery of GPCR-Associated Protein Complexes - Expression, Purification and Analysis of GProtein-Coupled Receptor Kinases - Modern Methods to Investigate the Oligomerization of Glycoprotein Hormone Receptors (TSHR,LHR, FSHR)
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