Bioactive Heterocyclic Compound Classes. Pharmaceuticals and Agrochemicals, 2 Volume Set

  • ID: 2253864
  • Book
  • 670 Pages
  • John Wiley and Sons Ltd
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Due to the fact that a large number of natural products, such as hormones, antibiotics, and vitamins, are composed of heterocyclic structures, this is an important branch of organic chemistry.

In these two volumes, each of the around 40 chapters covers one class of heterocycle, clearly structured as follows:

∗ Structural formulas of most important examples (market products)

∗ Short background of history or discovery

∗ Typical syntheses of important examples

∗ Mode of action

∗ Characteristic biological activity

∗ Structure–activity relationship

∗ Additional chemistry information

∗ References.

A valuable one–stop reference source for researchers in academia and industry as well as for graduate students with career aspirations in the field of pharmaceutical and agrochemical chemistry.
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INTRODUCTION

I. PHARMACEUTICALS

NEUROLOGICAL DISORDERS

Tropanes

Morphines

Barbituric Acid

Phenothiazine

Aryl Piperazines

Aryl Piperidines

Benzazepines

CARDIOVASCULAR DISEASES

Dihydropyridines

Tetrazoles

Thiazides

Tetrahydropyranones

INFECTIOUS DISEASES

Adenines

Guanines

Penicillins and Cephalosporins

ONCOLOGY

Pyrimidines

Triazoles

INFLAMMATION AND GASTROINTESTINAL DISEASES

Glucocorticoids

Benzimidazoles

METABOLIC DISEASES

Thiazolidinediones

II. AGROCHEMICALS

INTRODUCTION

HERBICIDES

Triazines

Pyrimidine and Triazine Sulfonylureas

Triazolopyrimidines

Benzoylpyrazoles

Pyridyloxyphenoxypropionates

Imidazolinones

Uracils

FUNGICIDES

Benzimidazoles

Morpholines

Triazoles

Anilinopyrimidines

Phenylpyrroles

Pyrimidine Strobilurins

Pyrazole carboxamides

INSECTICIDES

Avermectins

Pyridine and Thiazole Neonicotinoids

Pyrazole and Pyrimidine Acaricides

Phenylpyrazole Fiproles

Pyrazolylpyridine Diamides

Tetronic Acids
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Clemens Lamberth is a senior team leader in the crop protection research department of Syngenta AG, Switzerland. He studied chemistry at the Technical University of Darmstadt, Germany, where he obtained his Ph.D. under the supervision of Prof. Bernd Giese in 1990. Subsequently, he spent one and a half years as a postdoctoral fellow in the group of Prof. Mark Bednarski at the University of California at Berkeley (USA). In 1992 Clemens Lamberth joined the agrochemical research department of Sandoz Agro AG, Switzerland, which is today, after two mergers, part of Syngenta Crop Protection AG. Since 20 years he is specialized in fungicide discovery. He was the organizer of the two–day session "New Trends for Agrochemicals" at the 2nd EUCHEMS congress in Torino, Italy, 2008. He is the author of 46 publications and 56 patents and the inventor of Syngenta′s fungicide mandipropamid (Revus®, Pergado®).

Jürgen Dinges obtained his M.S. degree in organic chemistry at the Technical University in Darmstadt, Germany, in 1988. He then joined the group of Prof. Frieder W. Lichtenthaler at the same university, where he received his Ph.D. degree in organic chemistry and chemical engineering in 1991. After being awarded a Feodor–Lynen scholarship from the Humboldt foundation, he spent 18 months as a postdoctoral fellow in the group of Prof. William G. Dauben at the University of California at Berkeley (USA). In 1993, Jürgen Dinges joined the department for biochemistry at Syntex, USA and since 1995 he is working in the pharmaceutical research department at Abbott Laboratories, USA. During his 18 years of industrial experience, Jürgen Dinges has specialized in drug discovery. In 2009, he was a guest editor for "Current Topics in Medicinal Chemistry" for a special issue on Parkinson′s disease. He is an author of 17 publications and 23 patents and a co–inventor of more than 10 clinical drug development candidates.

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