Oligomerization and Allosteric Modulation in G-Protein Coupled Receptors, Vol 115. Progress in Molecular Biology and Translational Science

  • ID: 2299018
  • Book
  • 488 Pages
  • Elsevier Science and Technology
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In this thematic volume of Progress in Molecular Biology and Translational Science, researchers reflect on recent developments and research surrounding G protein-coupled receptors. The chapters cover a large breadth of research, including GPCR role in stem cell function and pharmacology.

Authors explore in-depth research techniques and applications of GPCR usage, covering theory, laboratory approaches, and unique qualities that make GPCRs a crucial tool in microbiological and cancer research.

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field

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- Approaches for Probing Allosteric Interactions at 7 Transmembrane Spanning Receptors

Michael T. Klein, Paige N. Vinson and Colleen M. Niswender

- Pharmacology of Metabotropic Glutamate Receptor Allosteric Modulators: Structural Basis and Therapeutic Potential for CNS Disorders

Karen J. Gregory, Meredith J. Noetzel and Colleen M. Niswender

- Mining the Potential of Label-Free Biosensors for Seven-Transmembrane Receptor Drug Discovery

Magalie Rochville, Julio Martin, Jeffrey Clifford Jerman & Evi Kostenis

- G Protein-Coupled Receptors in Cancer : Biochemical Interactions and Drug Design

Yves Audigier, François-Xavier Picault, Carline Chaves-Almagro and Bernard Masri

- GPCRs in Stem Cell Function

Van A. Doze and Dianne M. Perez

- Application of Receptor Theory to Allosteric Modulation of Receptors

David A. Hall

- What Ligand-Gated Ion Channels Can Tell Us about the Allosteric Regulation of G protein-Coupled Receptors

Frederick J. Ehlert

- Modelling Cooperativity Effects in Dimeric G Protein-Coupled Receptors

Jesús Giraldo

- Chemokine Receptor Oligomerization and Allostery

Bryan Stephens and Tracy M. Handel

- Fine-Tuning of GPCR Signals by Intracellular G Protein Modulators Peishen Zhao, Wendy Cladman, Hubert HM Van Tol and Peter Chidiac
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