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Molecular Aspects of Neurodegeneration and Neuroprotection

  • ID: 2317179
  • Book
  • January 2011
  • Region: Global
  • Bentham Science Publishers Ltd
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Neurodegenerative diseases are a complex heterogeneous group of diseases associated with site-specific premature and slow death of certain neuronal populations in brain and spinal cord tissues. For example, in Alzheimer disease, neuronal degeneration occurs in the nucleus basalis, whereas in Parkinson disease, neurons in the substantia nigra die. The most severely affected neurons in Huntington disease are striatal medium spiny neurons. The neuronal populations that are lost in neurodegenerative diseases modulate functions such as controlling movements, processing sensory information, memory, and making decisions. Although, the molecular mechanism of neurodegeneration remains unknown, but excitotoxicity, inflammation, and oxidative stress may contribute to neural cell demise independently or synergistically.The purpose of this E-book is to present readers with cutting edge and comprehensive information on molecular aspects of neurodegenerative diseases and neuroprotection in a manner that is useful not only to students and teachers, but also to researchers and physicians.
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Foreword i
Preface ii
List of Contributors iii
Acknowledgements vi

1. Arachidonic Acid and Docosahexaenoic Acid-derived Lipid Mediators in Brain 1
Akhlaq A. Farooqui

2. Neurochemical Aspects of Inflammation in Brain 10
Akhlaq A. Farooqui

3. Suitable Biomarkers of Oxidative Stress in Neurodegenerative Diseases 23
Fabio Coppedè and Lucia Migliore

4. Kainic Acid-mediated Neural Cell Death in Brain: Interplay among Glycerophospholipid, Sphingolipid-, and Cholesterol-derived Lipid Mediators 39
Wei-Yi Ong and Akhlaq A. Farooqui

5. Association of Mitochondrial Signaling in Alzheimer's Disease and Hypoxia 50
Cristina Carvalho, Sónia C. Correia, Renato X. Santos, Susana Cardoso, Paula I. Moreira, Xiongwei Zhu, Mark A. Smith, George Perry

6. Dopamine-Mediated Oxidative Stress Associated with Neurodegeneration in Parkinson Disease 62
Tahira Farooqui

7. Contribution of Complement in Neurodegenerative and Neuroinflammatory Diseases 72
Annapurna Nayak, Uday Kishore, DM Bonifati

8. The Roles of Platelet-activating Factor (PAF) and its Related Signaling and Metabolism in Neurological Diseases 90
Yutaka Hirashima

9. Novel Mechanism for Oxidative Stress in Neurodevelopmental Pathophysiology and Course of Schizophrenia 102
Anvita Kale , Sadhana R. Joshi and Sahebarao P. Mahadik

10. Neuroprotective Actions of Polyunsaturated Fatty Acids with Particular Reference to Alzheimer's disease 121
Undurti N Das

11. Future Perspective: Directions for Future Development on Various Aspects of Neurodegeneration and Neuroprotection in Neurological Disorders 132
Akhlaq A. Farooqui and Tahira Farooqui

Index 140
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Editor: Akhlaq Farooqui
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