After providing some background information the book covers aspects of sample collection, transport, storage and disposal, and sample preparation. Analytical techniques – colour tests and spectrophotometry, chromatography and electrophoresis, mass spectrometry, and immunoassay are covered in depth, and a chapter is devoted to the analysis of trace elements and toxic metals. General aspects of method implementation/validation and laboratory operation are detailed, as is the role of the toxicology laboratory in validating and monitoring the performance of point of care testing (POCT) devices. The book concludes with reviews of xenobiotic absorption, distribution and metabolism, pharmacokinetics, and general aspects of the interpretation of analytical toxicology results.
- A clearly written, practical, integrated approach to the basics of analytical toxicology.
- Focuses on analytical, statistical and pharmacokinetic principles rather than detailed applications.
- Assumes only a basic knowledge of analytical chemistry.
- An accompanying website provides additional material and links to related sites [external URL]
Written by an experienced team of authors, this book will prove invaluable for those starting out in a career in analytical toxicology across a wide range of disciplines including clinical and forensic science, food safety, and pharmaceutical development.
Health and Safety.
Nomenclature, Symbols and Conventions.
Amount Concentration and Mass Concentration.
List of Abbreviations.
1. Analytical Toxicology: Overview.
2. Sample Collection, Transport, and Storage.
3. Sample Preparation.
4. Colour Tests, and Spectrophotometric and Luminescence techniques.
5. Introduction to Chromatography and Capillary Electrophoresis.
6. Thin–Layer Chromatography.
7. Gas Chromatography.
8. High–Performance Liquid Chromatography.
9. Capillary Electrophoretic Techniques.
10. Mass Spectrometry.
11. Trace Elements and Toxic Metals.
12. Immunoassays and Enzyme–Based Assays.
13. Toxicology Testing at the Point of care.
14. Basic Laboratory Operations.
15. Absorption, Distribution, Metabolism and Excretion of Xenobiotic Compounds.
17. Clinical Interpretation of Analytical Results.
"This text comes highly recommended for any analytical toxicology trainee." (The Bulletin of the Royal College of Pathologists, April 2009)
"The book will be welcomed in the resource arsenal of the practicing toxicologist. Many toxicologists will add this important reference to their libraries because it competently fills a need at an acceptable cost." (International Journal of Toxicology, September 2008)
"The book is very well illustrated, easy to understand and pleasant to read, and contains a wealth of dedicated information." (International Journal of Environmental and Analytical Chemistry, August 2008)