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Fundamentals of Analytical Toxicology

  • ID: 2325455
  • Book
  • January 2008
  • Region: Global
  • 544 Pages
  • John Wiley and Sons Ltd
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The analytical toxicologist may be required to detect, identify, and in many cases measure a wide variety of compounds in samples from almost any part of the body or in related materials such as residues in syringes or in soil. This book aims to give principles and practical information on the analysis of drugs and poisons in biological specimens, particularly clinical and forensic specimens.

After providing some background information the book covers aspects of sample collection, transport, storage and disposal, and sample preparation. Analytical techniques – colour tests and spectrophotometry, chromatography and electro­phoresis, mass spectrometry, and immunoassay are covered in depth, and a chapter is devoted to the analysis of trace elements and toxic metals. General aspects of method implementation/validation and laboratory operation are detailed, as is the role of the toxicology laboratory in validating and monitoring the performance of point of care testing (POCT) devices. The book concludes with reviews of xenobiotic absorption, distribution and metabolism, pharmacokinetics, and general aspects of the interpretation of analytical toxicology results.

- A clearly written, practical, integrated approach to the basics of analytical toxicology.
- Focuses on analytical, statistical and pharmacokinetic principles rather than detailed applications.
- Assumes only a basic knowledge of analytical chemistry.
- An accompanying website provides additional material and links to related sites [external URL]

Written by an experienced team of authors, this book will prove invaluable for those starting out in a career in analytical toxicology across a wide range of disciplines including clinical and forensic science, food safety, and pharmaceutical development.
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Health and Safety.

Nomenclature, Symbols and Conventions.

Amount Concentration and Mass Concentration.


List of Abbreviations.

1. Analytical Toxicology: Overview.

2. Sample Collection, Transport, and Storage.

3. Sample Preparation.

4. Colour Tests, and Spectrophotometric and Luminescence techniques.

5. Introduction to Chromatography and Capillary Electrophoresis.

6. Thin–Layer Chromatography.

7. Gas Chromatography.

8. High–Performance Liquid Chromatography.

9. Capillary Electrophoretic Techniques.

10. Mass Spectrometry.

11. Trace Elements and Toxic Metals.

12. Immunoassays and Enzyme–Based Assays.

13. Toxicology Testing at the Point of care.

14. Basic Laboratory Operations.

15. Absorption, Distribution, Metabolism and Excretion of Xenobiotic Compounds.

16. Pharmacokinetics.

17. Clinical Interpretation of Analytical Results.


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Robert J. Flanagan
Andrew A. Taylor
Ian D. Watson
Robin Whelpton
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