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Six-Membered Transition States in Organic Synthesis

  • ID: 2325588
  • Book
  • 224 Pages
  • John Wiley and Sons Ltd
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How stereoselective reactions occur through six–membered transition states

This book is a definitive guide for furthering readers′ understanding of the amazing features of six–membered transition states in stereoselective organic reactions. Comprehensive and logically organized, it:

  • Covers reactions classified in four categories: [3,3]–sigmatropic rearrangements, aldol reactions, metal allylation reactions, and stereoselective reductions

  • Includes "General Considerations" for each category in which the author presents computational studies that support a proposal of a six–membered state

  • Provides a thorough discussion of each reaction category, including an introduction and history, a discussion of the corresponding six–membered transition state, and details of synthetic applications in natural product synthesis

  • Incorporates real–life applications of these transition states to the total syntheses of biologically active natural products

  • Covers literature up to 2006, with the original references cited for further study

This is a premier reference for organic chemists, medicinal chemists, and physical organic chemists and researchers in industries and institutes focusing on fine chemicals, including pharmaceuticals, agriculture/biotech, and polymers/materials. It is also an illuminating text for upper–level undergraduate and graduate students in organic chemistry. The author′s primary goal is to assist professors, researchers, and students in proposing reasonable transition states for the description of newly discovered stereo–selective reactions.

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1 [3,3]–Sigmatropic Rearrangements.

General Considerations.


1.1 Claisen Rearrangement.

1.2 Johnson Claisen Rearrangement.

1.3 Ireland Claisen Rearrangement.

1.4 Cope Rearrangement.

1.5 Anionic Oxy–Cope Rearrangement.

1.6 Aza–Cope Mannich Reaction.

2 Aldol Reactions.

General Considerations.


2.1 Asymmetric Syn–Aldol Reaction.

2.2 Asymmetric Anti–Aldol Reaction.

2.3 Proline–Catalyzed Asymmetric Aldol Reaction.

3 Metal Allylation Reactions.

General Considerations.


3.1 Boron Allylation Reaction.

3.2 Silicon Allylation Reaction.

4 Stereoselective Reductions.

General Considerations.


4.1 Diastereoselective Syn–Reduction of –Hydroxy Ketones.

4.2 Diastereoselective Anti–Reduction of –Hydroxy Ketones.

4.3 Asymmetric Reduction.

List of Copyrighted Materials.


Subject Index.

Scheme Index of Natural Products.

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Jaemoon Yang
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