Supramolecular Chemistry. 2nd Edition

  • ID: 2325751
  • Book
  • 990 Pages
  • John Wiley and Sons Ltd
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Supramolecular chemistry is chemistry beyond the molecule – the chemistry of molecular assemblies and intermolecular bonds. It is one of today s fastest growing disciplines, crossing a range of subjects from biological chemistry to materials science; and from synthesis to spectroscopy.

Supramolecular Chemistry is an up–to–date, integrated textbook that tells the newcomer to the field everything they need to know to get started. Assuming little in the way of prior knowledge, the book covers the concepts behind the subject, its breadth, applications and the latest contemporary thinking in the area. It also includes coverage of the more important experimental and instrumental techniques needed by supramolecular chemists.

The book has been thoroughly updated for this second edition. In addition to the strengths of the very popular first edition, this comprehensive new version expands coverage into a broad range of emerging areas. Clear explanations of both fundamental and nascent concepts are supplemented by up–to–date coverage of exciting emerging trends in the literature. Numerous examples and problems are included throughout the book. A system of key references allows rapid access to the secondary literature, and of course comprehensive primary literature citations are provided. A selection of the topics covered is listed below.

  • Cation, anion, ion–pair and molecular host–guest chemistry
  • Crystal engineering
  • Topological entanglement
  • Clathrates
  • Self–assembly,
  • Molecular devices
  • Dendrimers
  • Supramolecular polymers
  • Microfabrication
  • Nanoparticles
  • Chemical emergence
  • Metal–organic frameworks
  • Gels
  • Ionic liquids
  • Supramolecular catalysis
  • Molecular electronics
  • Polymorphism
  • Gas sorption
  • Anion–π interactions
  • Nanochemistry

Supramolecular Chemistry is a must for both students new to the field and for experienced researchers wanting to explore the origins and wider context of their work.

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About the Authors.

Preface to the First Edition.

Preface to the Second Edition.


1 Concepts.

1.1 Definition and Development of Supramolecular Chemistry.

1.2 Classification of Supramolecular Host Guest Compounds.

1.3 Receptors, Coordination and the Lock and Key Analogy.

1.4 Binding Constants.

1.5 Cooperativity and the Chelate Effect.

1.6 Preorganisation and Complementarity.

1.7 Thermodynamic and Kinetic Selectivity, and Discrimination.

1.8 Nature of Supramolecular Interactions.

1.9 Solvation and Hydrophobic Effects.

1.10 Supramolecular Concepts and Design.

2 The Supramolecular Chemistry of Life.

2.1 Biological Inspiration for Supramolecular Chemistry.

2.2 Alkali Metal Cations in Biochemistry.

2.3 Porphyrins and Tetrapyrrole Macrocycles.

2.4 Supramolecular Features of Plant Photosynthesis.

2.5 Uptake and Transport of Oxygen by Haemoglobin.

2.6 Enzymes and Coenzymes.

2.7 Neurotransmitters and Hormones.

2.8 Semiochemistry in the Natural World.

2.9 DNA.

2.10 Biochemical Self–Assembly.

3 Cation–Binding Hosts.

3.1 Introduction to Coordination Chemistry.

3.2 The Crown Ethers.

3.3 The Lariat Ethers and Podands.

3.4 The Cryptands.

3.5 The Spherands.

3.6 Nomenclature of Cation–Binding Macrocycles.

3.7 Selectivity of Cation Complexation.

3.8 Solution Behaviour.

3.9 Synthesis: The Template Effect and High Dilution.

3.10 Soft Ligands for Soft Metal Ions.

3.11 Proton Binding: The Simplest Cation.

3.12 Complexation of Organic Cations.

3.13 Alkalides and Electrides.

3.14 The Calixarenes.

3.15 Carbon Donor and –acid Ligands.

3.16 The Siderophores.

4 Anion Binding.

4.1 Introduction.

4.2 Biological Anion Receptors.

4.3 Concepts in Anion Host Design.

4.4 From Cation Hosts to Anion Hosts a Simple Change in pH.

4.5 Guanidinium–Based Receptors.

4.6 Neutral Receptors.

4.7 Inert Metal–Containing Receptors.

4.8 Common Core Scaffolds.

5 Ion Pair Receptors.

5.1 Simultaneous Anion and Cation Binding.

5.2 Labile Complexes as Anion Hosts.

5.3 Receptors for Zwitterions.

6 Molecular Guests in Solution.

6.1 Molecular Hosts and Molecular Guests.

6.2 Intrinsic Curvature: Guest Binding by Cavitands.

6.3 Cyclodextrins.

6.4 Molecular Clefts and Tweezers.

6.5 Cyclophane Hosts.

6.6 Constructing a Solution Host from Clathrate–Forming Building Blocks: The Cryptophanes.

6.7 Covalent Cavities: Carcerands and Hemicarcerands.

7 Solid–State Inclusion Compounds.

7.1 Solid–State Host–Guest Compounds.

7.2 Clathrate Hydrates.

7.3 Urea and Thiourea Clathrates.

7.4 Other Channel Clathrates.

7.5 Hydroquinone, Phenol, Dianin s Compound and the Hexahost Strategy.

7.6 Tri–o–thymotide.

7.7 Cyclotriveratrylene.

7.8 Inclusion Compounds of the Calixarenes.

7.9 Solid–Gas and Solid–Liquid Reactions in Molecular Crystals.

8 Crystal Engineering.

8.1 Concepts.

8.2 Crystal Nucleation and Growth.

8.3 Understanding Crystal Structures.

8.4 The Cambridge Structural Database.

8.5 Polymorphism.

8.6 Co–crystals.

8.7 Z > 1.

8.8 Crystal Structure Prediction.

8.9 Hydrogen Bond Synthons Common and Exotic.

8.10 Aromatic Rings.

8.11 Halogen Bonding and Other Interactions.

8.12 Crystal Engineering of Diamondoid Arrays.

9 Network Solids.

9.1 What Are Network Solids?

9.2 Zeolites.

9.3 Layered Solids and Intercalates.

9.4 In the Beginning: Hoffman Inclusion Compounds and Werner Clathrates.

9.5 Coordination Polymers.

10 Self–Assembly.

10.1 Introduction.

10.2 Proteins and Foldamers: Single Molecule Self–Assembly.

10.3 Biochemical Self–Assembly.

10.4 Self–Assembly in Synthetic Systems: Kinetic and Thermodynamic Considerations.

10.5 Self–Assembling Coordination Compounds.

10.6 Self–Assembly of Closed Complexes by Hydrogen Bonding.

10.7 Catenanes and Rotaxanes.

10.8 Helicates and Helical Assemblies.

10.9 Molecular Knots.

11 Molecular Devices.

11.1 Introduction.

11.2 Supramolecular Photochemistry.

11.3 Information and Signals: Semiochemistry and Sensing.

11.4 Molecule–Based Electronics.

11.5 Molecular Analogues of Mechanical Machines.

11.6 Nonlinear Optical Materials.

12 Biological Mimics and Supramolecular Catalysis.

12.1 Introduction.

12.2 Cyclodextrins as Enzyme Mimics.

12.3 Corands as ATPase Mimics.

12.4 Cation–Binding Hosts as Transacylase Mimics.

12.5 Metallobiosites.

12.6 Haem Analogues.

12.7 Vitamin B12 Models.

12.8 Ion Channel Mimics.

12.9 Supramolecular Catalysis.

13 Interfaces and Liquid Assemblies.

13.1 Order in Liquids.

13.2 Surfactants and Interfacial Ordering.

13.3 Liquid Crystals.

13.4 Ionic Liquids.

13.5 Liquid Clathrates.

14 Supramolecular Polymers, Gels and Fibres.

14.1 Introduction.

14.2 Dendrimers.

14.3 Covalent Polymers with Supramolecular Properties.

14.4 Self–Assembled Supramolecular Polymers.

14.5 Polycatenanes and Polyrotaxanes.

14.6 Biological Self–Assembled Fibres and Layers.

14.7 Supramolecular Gels.

14.8 Polymeric Liquid Crystals.

15 Nanochemistry.

15.1 When Is Nano Really Nano?

15.2 Nanotechnology: The Top Down and Bottom Up Approaches.

15.3 Templated and Biomimetic Morphosynthesis.

15.4 Nanoscale Photonics.

15.5 Microfabrication, Nanofabrication and Soft Lithography.

15.6 Assembly and Manipulation on the Nanoscale.

15.7 Nanoparticles.

15.8 Endohedral Fullerenes, Nanotubes and Graphene.


Thought Experiment.



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?This second edition ofSupramolecular Chemistry, achieves a difficult task ? both capturing the excitement at the cutting–edge of this active research field, while also providing an in–depth educational introduction to the topic.? (Education in Chemistry , November 2009)

?Entries vary from single species to large groups; hence coverage is quite variable, though always informative. This volume will be useful for researchers and clinicians. Summing Up: Recommended.? (CHOICE, October 2009)

?At just under 1000 pages, the second edition of Steed and Atwood?s Supramolecular Chemistry is the most comprehensive overview of the area available in textbook form.? (Chemistry World, August 2009)

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