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The Septins

  • ID: 2325782
  • Book
  • 380 Pages
  • John Wiley and Sons Ltd
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Septins are an evolutionarily conserved group of GTP–binding and filament–forming proteins that were originally discovered in yeast. Once the preserve of a small band of yeast biologists, the field has grown rapidly in the past few years and now encompasses the whole of animal and fungal biology. Furthermore, septins are nowadays recognized to be involved in a variety of disease processes from neoplasia to neurodegenerative conditions.

  The Septins is the first comprehensive book devoted to the septin gene family and their proteins, providing those new to this research area with a detailed and wide ranging introduction to septin biology. It starts with a unique historical perspective on the development of the field, from its beginnings in the screen for cell division mutants by the Nobel Laureate Lee Hartwell. The evolution of the septin gene family then forms a basis for consideration of the biochemistry and functions of septins in yeast and other model organisms including C. elegans and Drosophila . 

A major part of the book considers the diversity of septins in mammals, their functions and properties as well as their involvement in normal and abnormal cellular states, followed by a speculative overview from the editors of the key questions in septin research and of where the field may be headed.
In addition, several appendices summarise important information for those in, or just entering, the field, e.g. nomenclature and septin and septin–like sequences.

  The Septins is an essential source of reference material for researchers in septin biology, cell biology, genetics and medicine, in particular pathology, including areas of neurobiology, oncology, infectious disease and developmental biology.
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Authors and Affiliations vii

An introduction to the septins 1

Peter A. Hall, S. E. Hilary Russell and John R. Pringle

Section I Setting the scene 5

Chapter 1 Origins and development of the septin field 7

John R. Pringle

Chapter 2 Evolution and conserved domains of the septins 35

Michelle Momany, Fangfang Pan and Russell L. Malmberg

Section II Septins in model systems 47

Chapter 3 Biochemical properties and supramolecular architecture of septin hetero–oligomers and septin filaments 49

Michael A. McMurray and Jeremy Thorner

Chapter 4 Yeast septins: a cortical organizer 101

Yves Barral

Chapter 5 Septins in four model fungal systems: diversity in form and function 125

Amy Gladfelter and Peter Sudbery

Chapter 6 Septins in the metazoan model systems Drosophila melanogaster and Caenorhabditis elegans 147

Christine M. Field, Amy Shaub Maddox, John R. Pringle and Karen Oegema

Section III Septins in mammals 169

Chapter 7 The genomics and regulation of the human septin

genes 171

S.E. Hilary Russell

Chapter 8 The functions of septins in mammals 187

Carol D. Froese and William S. Trimble

Chapter 9 Septin–interacting proteins in mammals 211

Brandon E. Kremer and Ian G. Macara

Chapter 10 Septin functions in the mammalian cytoskeleton 229

Elias T. Spiliotis and W. James Nelson

Chapter 11 Septins and the synapse 247

Jing Xue, Victor Anggono and Phillip J. Robinson

Chapter 12 Septins and platelets 269

Jerry Ware, Constantino Mart´ nez and Barbara Zieger

Chapter 13 Septins and apoptosis 281

Marie–Jeanne Carp and Sarit Larisch

Chapter 14 Septins and human disease 295

Peter A. Hall and Fern P. Finger

Chapter 15 Insight into septin functions from mouse models 319

Makoto Kinoshita

Section IV Envoi 337

Chapter 16 Septins: 2008 and beyond 339

Peter A. Hall, S.E. Hilary Russell and John R. Pringle

Appendix A Septin and septin–like sequences 343

Michelle Momany, Fangfang Pan and Russell L. Malmberg

Appendix B Mammalian septin nomenclature 351

Peter A. Hall, Elspeth Bruford, Hilary Russell, Ian G. Macara and John R. Pringle

Appendix C Septin meetings and workshops 355

Peter A. Hall and John R. Pringle

Index 361

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Peter A. Hall
S. E. Hilary Russell
John R. Pringle
Note: Product cover images may vary from those shown