Divided into two parts, the first section on methodology presents new innovative methods for enzymatic catalysis optimization, including such new trends as medium engineering, directed evolution and computer–aided prediction of enantioselectivity. The second and main section deals with applications to synthesis, showing important reaction types and their applications. Only those reactions with very high selectivity are presented, allowing readers to improve their own reaction yields.
The search for new enzymes:
Dynamic Kinetic Resolutions:
Deracemization and Enantioconvergent Processes:
Transesterification and hydrolysis of carboxylic acid derivatives, alcohols and epoxides
Aminolysis and ammonolysis of carboxylic acid derivatives:
Making and breaking C–C bonds: