Principles and Practice of Mixtures Toxicology

  • ID: 2326686
  • Book
  • 662 Pages
  • John Wiley and Sons Ltd
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The laboratory study of toxic substances usually involves one substance at a time. In the real world, however, organisms are often exposed to a complex mixture of toxins from air, water, food or medications. Assessing the toxic effects of these mixtures requires special know–how and techniques that can account for interactions between toxins in the human body, or in a natural ecosystem.

The goal of this book is to highlight basic concepts and new methods that will impact general toxicology, as well as the field of safety and risk assessment of chemicals and their mixtures. Prominent scholars and toxicologists have provided timely perspectives on how the latest science can be applied to existing problems with overviews of disciplines where significant progress has been made.

Topics covered include:

¿ Mixtures Toxicology and Risk Assessment

¿ Exposure Assessment and Biomonitoring

¿ Relative Potency Factor Approach

¿ Statistical Methods and Techniques

¿ Pharmacokinetics and Pharmacodynamics Interactions

¿ Hazardous waste sites, workplace exposures, drug combinations, water disinfection by–products, endocrine active chemicals, Food Ingredients

¿ Dermal Toxicity

¿ Polycyclic Aromatic Hydrocarbons (PAHs),

¿ Polychlorinated Biphenyls (PCBs), and Nanoparticles

The book is targeted to practicing and future toxicologists in academia, government and industry and will be especially useful to individuals interested in risk assessments where all these techniques come into play. The book constitutes the first comprehensive treatment of this subject in more than a decade.
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Chemical Mixtures in the Environment: Exposure Assessment

Application of a Relative Potency Factor Approach in the Assessment of Health Risks Associated with Exposures to Mixtures of Dioxin–Like Compounds

Statistical Methods in Risk Assessment of Chemical Mixtures

Kinetic Interactions of Chemical Mixtures

Toxicological Interaction Thresholds of Chemical Mixtures

Characterization of Toxicoproteomics Maps for Chemical Mixtures Using Information Theoretic Approach

Pharmacokinetic Mechanisms of Interactions in Chemical Mixtures

Chemical Mixtures and Cumulative Risk Assessment

Application of ATSDRs Mixtures Guidance for the Toxicity Assessment of Hazardous Waste Sites

Application of Mixture Methodology for Workplace Exposures

Assessing Risk of Drug Combinations

Dermal Chemical Mixtures

Synergy: A Risk Management Perspective

Chemistry, Toxicity, and Health Risk Assessment of Drinking Water Disinfection By–Products

Endocrine Active Chemicals

Evaluation of Interactions in Chemical Mixtures

Thyroid Active Environmental Pollutants and Their Interactions on the Hypothalamic–Pituitary–Thyroid (HPT) Axis

Toxic and Genotoxic Effects of Mixtures of Polycyclic Aromatic Hydrocarbons

Development of In Vitro Models to Assess Toxicity of Engineered Nanomaterials

The Application of Physiologically–Based Pharmacokinetics, Bayesian Population PBPK Modeling, and Biochemical Reaction Network Modeling to Chemical Mixture Toxicology

Food Ingredients Are Sometimes Mixtures

Biomonitoring

Adverse Drug Reactions and Interactions
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Moiz Mumtaz is a long–term scientific advisor at the U.S. Agency for Toxic Substances and Disease Registry (ATSDR), where he heads the agency–wide mixtures research program. Dr. Mumtaz obtained his Ph.D. in toxicology form the University of Maryland (USA) and holds M.S. degrees from Oregon State University and from Osmania University (India). He is also a faculty member of Emory University, Atlanta, teaching toxicology and risk assessment courses.
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