NOTE: Annals volumes are available for sale as individual books or as a journal. For more information on institutional journal subscriptions, please visit: Annals online and discounts on print volumes. Please visit <a href="[external URL] for more information on becoming a member.
Introduction for Thymosins in Health and Disease viiAllan I. Goldstein and Enrico Garaci
Thymosin 1: immunomodulation, immunopharmacology, infectious diseases, and cancers
Thymosin 1: a novel therapeutic option for patients with refractory chronic purulent rhinosinusitis 1Virgil A. S. H. Dalm, Harm de Wit and Hemmo A. Drexhage
Thymosin 1: in melanoma: from the clinical trial setting to the daily practice and beyond 8Riccardo Danielli, Ester Fonsatti, Luana Calabrò, Anna Maria Di Giacomo and Michele Maio
Thymosin 1 as a stimulatory agent of innate cell–mediated immune response 13Annalucia Serafino, Pasquale Pierimarchi, Francesca Pica, Federica Andreola, Roberta Gaziano, Noemi Moroni, Manuela Zonfrillo, Paola Sinibaldi–Vallebona and Enrico Garaci
Thymosin 1 continues to show promise as an enhancer for vaccine response 21Cynthia Tuthill, Israel Rios, Alfonso De Rosa and Roberto Camerini
Clinical and preclinical applications of thymosin 4: wound healing, eye injuries, cardiovascular diseases, and neurological injuries
The use of angiogenic–antimicrobial agents in experimental wounds in animals: problems and solutions 28Paritosh Suman, Harikrishman Ramachandran, Sossy Sahakian, Kamraan Z. Gill, Basil A. J. Horst, Shanta M. Modak and Mark A. Hardy
The regenerative peptide thymosin 4 accelerates the rate of dermal healing in preclinical animal models and in patients 37Terry Treadwell, Hynda K. Kleinman, David Crockford, Mark A. Hardy, Georgio T. Guarnera and Allan L. Goldstein
Thymosin 4: a potential novel dry eye therapy 45
Gabriel Sosne, Ping Qiu, George W. Ousler 3rd, Steven P. Dunn and David Crockford
Neuroprotective and neurorestorative effects of thymosin 4 treatment following experimental traumatic brain injury 51Ye Xiong, Asim Mahmood, Yuling Meng, Yanlu Zhang, Zheng Gang Zhang, Daniel C. Morris and Michael Chopp
Use of the cardioprotectants thymosin 4 and dexrazoxane during congenial heart surgery: proposal for a randomized, double–blind, clinical trial 59Daniel Stromberg, Tia Raymond, David Samuel, David Crockford, William Stigall, Steven Leonard, Eric Mendeloff and Andrew Gormley
Cardiac repair with thymosin 4 and cardiac reprogramming factors 66Deepak Srivastava, Masaki Ieda, Jidong Fu and Li Qian
Late breaking paper session
NMR structural studies of thymosin 1 and –thymosins 73David E. Volk, Cynthia W. Tuthill, Miguel–Angel Elizondo–Riojas and David G. Gorenstein
Fragments of –thymosin from the sea urchin Paracentrotus lividus as potential antimicrobial peptides against staphylococcal biofilms 79Domenico Schillaci, Maria Vitale, Maria Grazia Cusimano and Vincenzo Arizza
Development of an analytical HPLC methodology to study the effects of thymosin 4 on actin in sputum of cystic fibrosis patients 86Mahnaz Badamchain, Ali A. Damavandy and Allan L. Goldstein
The role of biologically active peptides in tissue repair using umbilical cord mesenchymal stem cells 93Carlos Cabrera, Gabriela Carriquiry, Chiara Pierinelli, Nancy Reinoso, Javier Arias–Stella and Javier Paino
Identification on interaction partners of –thymosins: applications of thymosin 4 labeled by transglutaminase 98Christine App, Jana Knop, Hans Georg Mannherz and Ewald Hannappel
Antibodies in research of thymosin 4: investigation of cross–reactivity and influence of fixatives 105Jana Knop, Christine App and Ewald Hannappel
Thymosin 4 sustained release from poly(lactide–co–glycolide) microspheres: synthesis and implications for treatment of myocardial ischemia 112Jeffrey E. Thatcher, Tré Welch, Robert C. Eberhart, Zoltan A. Schelly and J. Michael DiMaio
Allan L. Goldstein is professor and Catharine B. & William McCormick Chair of the department of Biochemistry and Molecular Biology at The George Washington University School of Medicine and Health Sciences, where he has served since 1978. He is a world–renowned authority on the thymus gland and the workings of the immune system, and co–discoverer of the thymosins.
Dr. Goldstein is the author of over 400 scientific articles in professional journals, the inventor on more than 15 U.S. Patents, and the editor of several books in the fields of biochemistry, biomedicine, immunology and neuroscience.
He is on the editorial boards of numerous scientific and medical journals and has been a consultant to many research organizations in industry and government; co–founder of The Institute for Advanced Studies in Aging and Geriatric Medicine, a non–profit research and educational institute; a member of the Board of Trustees of the Albert Sabin Vaccine Institute; and serves as the Chairman of the Board of RegeneRx Biopharmaceuticals.
Dr. Goldstein received his B.S. from Wagner College in 1959 and his M.S. and Ph.D. from Rutgers University in 1964. He served as a faculty member of the Albert Einstein College of Medicine from 1964 to 1972, and moved to the University of Texas Medical Branch in Galveston in 1972 as professor and director of the division of Biochemistry.