Apheresis: Principles and Practice, 3rd Edition CD-ROM

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This CD-ROM of the 3rd edition provides an easy way to explore a comprehensive account of the scientific, technical and clinical issues that arise in apheresis practice. Fully updated with the latest ASFA indication category assignments, this easy-to-use, fully searchable CD-ROM contains all the textbook information in one handy disk.
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About the Editors
1 Development of Apheresis Instrumentation
Frank Corbin; Herbert M Cullis; Emil J Freireich, MD, DSc (Hon ); Yoichiro Ito, MD;
Robert M Kellogg, PhD; Allen Latham, Jr ; and Bruce C McLeod, MD
Cohn Centrifuge
Haemonetics Instruments and the Latham Bowl
NCI-IBM Blood Cell Separator
Sealless Continuous Flow Centrifuge
Aminco Celltrifuge II and Fenwal CS3000
IBM 2997/COBE Spectra
Membrane Plasma Separation
2 Applications History
Edwin G Taft, MD
Manual Plasmapheresis and Plateletpheresis
Donor Plasmapheresis and Plateletpheresis by Blood Cell Separator
Pooled Platelets from Whole Blood vs Single-Donor Plateletpheresis
Continuous-Flow Centrifuge
Therapeutic Plateletpheresis
Granulocyte Apheresis
Filtration Leukapheresis
Other Normal-Cell Leukapheresis
Leukapheresis of Pathologic Leukocytes
Red Cell Exchange and Related Procedures
Therapeutic Plasma Exchange
Category I Indications for Therapeutic Plasma Exchange
Non-Category-I Indications for TPE
References 3 Physiology of Apheresis
Kendall P Crookston, MD, PhD, and Deborah J Novak, MD
Fluid Shifts
Drug Interactions and Clearance
Cellular Loss
Plasma Protein Interactions
Adverse Effects
4 Current Instrumentation for Apheresis
Edwin A Burgstaler, MT, HP(ASCP)
Principles of Operation
Instruments for Leukapheresis, Plateletpheresis, and/or Plasma Collection
Instruments for Red Cell and Other Component Collection
Comparison of Donor Apheresis Systems
Therapeutic Applications
5 Selection and Care of Apheresis Donors
Christina Anderson, RN, BSN, HP(ASCP)
Selection of Apheresis Donors
Care of the Apheresis Donor
Special Types of Donations
6 Automated Donations: Plasma, Red Cells, and Multicomponent
Donor Procedures
James W Smith, MD, PhD
Plasma Donation by Apheresis
Red Cell and Multicomponent Donation by Apheresis
Donor Acceptance, Regulatory Concerns, and Administrative Issues
7 Apheresis Platelet Collection, Storage, Quality Assessment, and
Clinical Use
Ralph R Vassallo, Jr, MD, FACP, and Scott Murphy, MD
Platelet Physiology
Platelet Transfusion Dose
Liquid Storage of Platelets in Plasma
Liquid Storage of Platelets in Platelet Additive Solution Assessing Platelet Quality
Component Modification
8 Provision of Apheresis Platelet Transfusions: Patient and
Producer Perspectives
Thomas H Price, MD
Usage Trends
Characteristics of Apheresis and Pooled Platelets
Advantages and Disadvantages of Apheresis Platelets
9 Matched Apheresis Platelets
Janice G McFarland, MD
HLA Alloimmunization and Platelet Transfusions
ABH Antigens and Platelet Transfusion
Platelet-Specific Antigens and Platelet Transfusions
Diagnosis of Alloimmune Refractoriness
Matched Platelets in the Management of the Alloimmunized Patient
Elements of a Matched Donor Program
10 Bacterial Contamination of Platelet Products
Sara C Koenig, MD; Mark E Brecher, MD; and Yara A Park, MD
Clinical Presentation of Septic Transfusion Reactions
Organisms and Sources
Methods to Reduce the Risk of Transfusion-Acquired Sepsis
11 Granulocyte (Neutrophil) Transfusion
Ronald G Strauss, MD
Neutrophil (PMN) Physiology
Clinical Experience and Limitations of Granulocyte Transfusions
Technology of Granulocyte Collection and Transfusion
Future of Granulocyte (Neutrophil) Transfusions
12 Management of the Therapeutic Apheresis Patient
Vishesh Chhibber, MD, and Karen E King, MD
The Therapeutic Apheresis Service
The Therapeutic Apheresis Consultation
Extracorporeal Volume Evaluation and Management Vascular Access
Technical Difficulties and Catheter-Related Complications
Intraprocedural Care and Monitoring
Management of Special Patient Populations
Management of Adverse Events
13 Therapeutic Leukocyte and Platelet Depletion
Nicholas Bandarenko, MD, and Evelyn Lockhart, MD
Hyperleukocytosis and Leukostasis
Selective Leukocyte Apheresis
14 Basic Principles of Therapeutic Blood Exchange
Robert Weinstein, MD
Modeling the Effects of Plasma Exchange
Reduction of Blood Constituent Levels with Therapeutic Plasma Exchange
The Intensity of Therapeutic Plasma Exchange: Volume and Schedule
Replacement Fluids for Plasma Exchange
15 Therapeutic Apheresis in Neurologic Disorders
Bruce C McLeod, MD
Guillain-Barré Syndrome
Chronic Inflammatory Demyelinating Polyneuropathy
Peripheral Neuropathy with Monoclonal Gammopathy
Myasthenia Gravis
Lambert-Eaton Myasthenic Syndrome
Stiff-Person Syndrome
Other Paraneoplastic CNS Syndromes
Multiple Sclerosis and Neuromyelitis Optica
Other Neurologic Syndromes
16 Therapeutic Plasma Exchange in Hematologic Diseases and Dysproteinemias
Joseph E Kiss, MD
Thrombotic Thrombocytopenic Purpura and other Thrombotic Microangiopathies
ABO-Mismatched Hematopoietic Progenitor Cell Transplantation
Acquired Aplastic Anemia and Pure Red Cell Aplasia Autoimmune Hemolytic Anemia
Immune Thrombocytopenic Purpura
Coagulation Factor Inhibitors
Posttransfusion Purpura
Therapeutic Plasma Exchange in Dysproteinemias
17 Therapeutic Plasma Exchange for Renal and Rheumatic Diseases
Andre A Kaplan, MD, FACP, FASN
GBM-Antibody-Mediated Disease (Goodpasture Syndrome)
Rapidly Progressive Glomerulonephritis Not Associated with Anti-GBM
Renal Failure in Multiple Myeloma
IgA Nephropathy and Henoch-Schonlein Purpura
Systemic Lupus Erythematosus
Lupus Anticoagulant, Anticardiolipin Antibodies, and the Antiphospholipid Syndrome
Hemolytic Uremic Syndrome
Renal Transplantation
18 Apheresis in Solid Organ Transplantation
Marisa B Marques, MD
Renal Transplantation
Heart Transplantation
Lung Transplantation
Liver Transplantation
19 Red Cell Exchange and Other Therapeutic Alterations of Red Cell Mass
Beth H Shaz, MD
Techniques for Red Cell Exchange
Indications for Red Cell Exchange
Indications for Red Cell Depletion
20 Selective Extraction of Plasma Constituents
Jeffrey L Winters, MD
Double Filtration Plasmapheresis
Nonspecific Immunoadsorption
Specific Immunoadsorption: Glycosorb
LDL Apheresis
References 21 Therapeutic Apheresis in Pediatric Patients
Haewon C Kim, MD
Special Considerations in Application of Apheresis in Pediatric Patients
Procedural Modifications for Pediatric Apheresis
Intravascular Volume Management
Pediatric Apheresis Procedures
Pediatric Diseases Treated by Therapeutic Apheresis
Adverse Effects
22 Hematopoietic Stem Cell Transplantation: An Overview
John R Wingard, MD; Baldeep Wirk, MD; and Randy Brown, MD
Historical Perspective
The Transplant Procedure
Indications for HSCT
Future Trends
23 Mobilization and Collection of Peripheral Blood Hematopoietic
Progenitor Cells
Joseph Schwartz, MD; Anand Padmanabhan, MD, PhD; Richard O Francis, MD, PhD;
and Michael L Linenberger, MD, FACP
Clinical Applications of Blood HPCs
Mobilization of HPCs
HPC Collection by Apheresis
Standards and Regulatory Considerations for HPC(A) Products
Special Considerations for Mobilization and Collection of Autologous HPC(A)
Adverse Events
24 Receipt, Processing, and Infusion of Hematopoietic Progenitor and
Therapeutic Cells
Kathryn M Bushnell, MT(ASCP), and Zbigniew M Szczepiorkowski, MD, PhD, FCAP
Types of Hematopoietic Stem Cell Transplantation
Characteristics of Hematopoietic Progenitor Cell Products
Hematopoietic Progenitor Cells—Product Types
Collection, Processing, Issue, and Administration
25 Regenerative Medicine
Daniela S Krause, MD, PhD, and David T Scadden, MD
Regeneration from Endogenous Cells
Exogenous Tissue Regeneration by Transplantation
Clinical Applications of Cells with Regenerative Potential
26 Autologous Cellular Immunotherapies
David W O’Neill, MD
Active Cellular Immunotherapies (Dendritic Cell/Antigen-Presenting Cell Vaccines)
Adoptive Cell Transfer
27 Allogeneic Adoptive Immunotherapy with Apheresis Products
David L Porter, MD, and Joseph H Antin, MD
Graft-vs-Tumor Effects in Murine Models of Transplantation
Evidence for a Graft-vs-Tumor Effect in Clinical Transplantation
Treatment of Relapsed Leukemia After Allogeneic Transplantation:
Graft-vs-Leukemia Induction with Donor Lymphocyte Infusions
Toxicity of Adoptive Immunotherapy
New Strategies of Adoptive Immunotherapy
Prophylactic DLI
Cytokine-Mediated Immunotherapy
Adoptive Immunotherapy for Nonrelapse Complications After Allogeneic HSCT
28 Photopheresis
Jaehyuk Choi, MD, PhD, and Francine M Foss, MD
ECP Procedure
Therapeutic Applications of Photopheresis
Clinical Trials of ECP in Autoimmune Disorders
Mechanisms of ECP
29 Cellular Gene Therapy
P Dayanand Borge, Jr, MD, PhD, and Harvey G Klein, MD
Basic Requirements of Gene Transfer Technology
Desirable Properties of a Gene Delivery Vehicle
Applications of Cellular Gene Therapy
Regulatory and Safety Issues
Future Prospects
30 Regulatory Environment for Apheresis Facilities and Personnel
Michelle A Vauthrin, MT(ASCP)SBB, and Jillian Ferschke, BS
Regulatory Agencies
Professional Organizations
References 31 Principles of Quality Management for Apheresis Facilities
Christopher Chun, MT, HP(ASCP)
FDA Criteria
AABB Criteria
FACT Criteria
Minimal Quality System Elements
Suggested Reading
32 Quality Management of Apheresis Personnel
Wanda B Koetz, RN, HP(ASCP)
Employee Categories and Roles
Management of Individuals
Management of the Apheresis Unit
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