Principles of Cloning, Second Edition is the fully revised edition of the authoritative book on the science of cloning. The book presents the basic biological mechanisms of how cloning works and progresses to discuss current and potential applications in basic biology, agriculture, biotechnology, and medicine. Beginning with the history and theory behind cloning, the book goes on to examine methods of micromanipulation, nuclear transfer, genetic modification, and pregnancy and neonatal care of cloned animals. The cloning of various species-including mice, sheep, cattle, and non-mammals-is considered as well. The Editors have been involved in a number of breakthroughs using cloning technique, including the first demonstration that cloning works in differentiated cells done by the Recipient of the 2012 Nobel Prize for Physiology or Medicine - Dr John Gurdon; the cloning of the first mammal from a somatic cell - Drs Keith Campbell and Ian Wilmut; the demonstration that cloning can reset the biological clock - Drs Michael West and Robert Lanza; the demonstration that a terminally differentiated cell can give rise to a whole new individual - Dr Rudolf Jaenisch and the cloning of the first transgenic bovine from a differentiated cell - Dr Jose Cibelli. The majority of the contributing authors are the principal investigators on each of the animal species cloned to date and are expertly qualified to present the state-of-the-art information in their respective areas.
- First and most comprehensive book on animal cloning, 100% revised
- Describes an in-depth analysis of current limitations of the technology and research areas to explore
- Offers cloning applications on basic biology, agriculture, biotechnology, and medicine
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PART ONE-BASIC BIOLOGICAL PROCESES
Activation of Mammalian Oocytes.
Nuclear Reprogramming: Biological and Technological Constraints.
Plasticity of Somatic Nucleus by Epigenetic Reprogramming via Cell Hybridization.
Determinants of Pluripotency in Mammals.
Cloning and Aging.
Micromanipulation Techniques for Cloning.
Microinsemination and Nuclear Transfer with Male Germ Cells.
Development of Viable Mammalian Embryos in Vitro: Evolution of Sequential Media.
Genetic and Phenotypic Similarity Among Members of Mammalian Clonal Sets.
Genetic Modification and Cloning in Mammals.
Pregnancy and Neonatal Care of Clone Animals.
Donor Cell Type and Cloning Efficiency in Mammals.
PART THREE-CLONING BY SPECIES
The Cloning of Amphibians.
Cloning of Fish.
Cloning of Mice.
Cloning of Rabbits.
Nuclear Transfer in Swine.
Cloning of Cattle.
Cloning of Sheep.
Cloning of Goats.
PART FOUR-CURRENTLY SOUGHT AFTER SPECIES
Cloning of Endangered Species.
Cloning of Rats.
PART FIVE-NUCLEAR TRANSFER IN PRIMATES
Cloning in Non-Human Primates.
Nuclear Transfer for Stem Cells (CRNT).
Current Research and Commercial Applications of Cloning Technology.
Transgenic Cloned Goats and the Production of Therapeutic Proteins.
PART SEVEN-ETHICAL AND LEGAL AFFAIRS
Ethical Implications of Cloning.
Mammalian Cloning- Challenges for the Future.
Dr. Jose Cibelli is internationally recognized as one of the pioneers in the area of cloning for the production of animals and embryonic stem cells. Dr. Cibelli and his colleagues were responsible for the generation of the world's first transgenic cloned calves, the first stem cells by nuclear transfer in bovine, and the first embryonic stem cells by parthenogenesis in primates. His work has been published in numerous scientific journals including Science, Nature Biotechnology, Nature Medicine, Nature Methods, PNAS, and JAMA. He has testified about cloning in public forums sponsored by the US Food and Drug administration, the USA National Academy of Sciences, Canadian House of Commons, the USA Department of Agriculture, the United Nations Commission for Human Rights and the British Royal Society. He is currently Professor of Animal Biotechnology at Michigan State University, USA.
Wilmut, Ian Sir
Robert Lanza, M.D. is currently Head of Astellas Global Regenerative Medicine, Chief Scientific Officer of AIRM and an adjunct professor at the Wake Forest Institute for Regenerative Medicine. Time magazine recognized him as one of the "100 Most Influential People in the World, and Prospect magazine named him one of the Top 50 "World Thinkers. His research focuses on stem cells and their potential to provide therapies for some of the world's most deadly and debilitating conditions. He has hundreds of scientific publications and over 30 books, including definitive references in the fields of tissue engineering and regenerative medicine. He is a former Fulbright Scholar, and studied with polio-pioneer Jonas Salk and Nobel laureates Gerald Edelman and Rodney Porter. He also worked closely (and co-authored a series of papers) with psychologist BF Skinner and heart transplant-pioneer Christiaan Barnard. Dr. Lanza received his undergraduate and medical degrees from the University of Pennsylvania, where he was both a University Scholar and Benjamin Franklin Scholar. Lanza was part of the team that cloned the world's first human embryo, the first endangered species, and published the first-ever reports of pluripotent stem cell use in humans.
Campbell, Keith H.S.