This book consists of 9 chapters which deal with different aspects of this kinase. These chapters are written by more than two dozen world-leading PAK experts. Each of these will provide updated biomedical information as well as future insight to a wide range of readers who are interested in this unique kinase and both its pathological and physiological roles as well as its functional evolution from its ancestral origins.
- This publication will be the very first book ever published solely focused on PAK family kinases.
- Each chapter deals with the latest progress in PAK research written by a leading PAK expert with his or her own ideas and insight.
- Each chapter of this book has been written in such a way that clinical doctors who seek the effective cure of these formidable diseases, in addition to research scientists and biomedical students will value this book.
- This book describes in detail a number of PAK blockers which would be potentially useful for the therapy of these PAK-dependent diseases, and some of them are indeed available on the market inexpensively, without any side effect.
Chapter 1: Functional Maturation of PAKs Chapter 2: Oncogenicity of PAKs and Their Substrates Chapter 3:Natural or Synthetic Therapeutics that Block PAKs Chapter 4:PAK1 in Parasites-Host Interaction Chapter 5: PAK1 in Brain Diseases Chapter 6: PAK1 in Alzheimer's and Huntington's diseases Chapter 7: PAK1 Controls the Lifespan Chapter 8: PAK 4-6 in Cancer and Neuronal Development