Epigenetics in Human Disease. Translational Epigenetics

  • ID: 2485098
  • Book
  • 592 Pages
  • Elsevier Science and Technology
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Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of epigenetic factors such as cancer, autoimmune disorders and aging as well as those that are yielding exciting breakthroughs in epigenetics such as diabetes, neurobiological disorders and cardiovascular disease. Where applicable, attempts are made to not only detail the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, but also novel epigenetic approaches to the treatment of these diseases. Chapters are also presented on human imprinting disorders, respiratory diseases, infectious diseases and gynecological and reproductive diseases. Since epigenetics plays a major role in the aging process, advances in the epigenetics of aging are highly relevant to many age-related human diseases. Therefore, this volume closes with chapters on aging epigenetics and breakthroughs that have been made to delay the aging process through epigenetic approaches. With its translational focus, this book will serve as valuable reference for both basic scientists and clinicians alike.

  • Comprehensive coverage of fundamental and emergent science and clinical usage
  • Side-by-side coverage of the basis of epigenetic diseases and their treatments
  • Evaluation of recent epigenetic clinical breakthroughs
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  1. Epigenetics of Human Disease

    Methods and Strategies to Determine Epigenetic Variation in Human Disease

    DNA Methylation Alterations in Human Cancers

    Alterations of Histone Modifications in Cancer

    MicroRNA in Oncogenesis

    Epigenetic Approaches to Cancer Therapy

    Epigenomics in Neurobehavioral Diseases

    Emerging Role of Epigenetics in Human Neurodevelopmental Disorders

    The Epigenetics of Alzheimer's Disease

    Epigenetic Modulation of Human Neurobiological Disorders

    Epigenetic Basis of Autoimmune Disorders in Humans

    Approaches to Autoimmune Diseases Using Epigenetic Therapy

    Epigenetic Mechanisms of Human Imprinting Disorders

    Epigenomic Factors in Human Obesity

    Epigenetic Approaches to Control Obesity

    Epigenetics of Diabetes in Humans

    The Potential of Epigenetic Compounds in Treating Diabetes

    Epigenetic Aberrations in Human Allergic Diseases,

    Therapy of Airway Disease: Epigenetic Potential

    The Role of Epigenetics in Cardiovascular Disease

    Epigenetics and Human Infectious Diseases

    The Epigenetics of Endometriosis

    Aberrant DNA Methylation in Endometrial Cancer

    Stem Cell Epigenetics and Human Disease

    Non-Coding RNA Regulatory Networks, Epigenetics, and Programming Stem Cell Renewal and Differentiation: Implications for Stem Cell Therapy

    Aging and Disease: The Epigenetic Bridge

    Early-Life Epigenetic Programming of Human Disease and Aging

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Tollefsbol, Trygve
Professor of Biology, University of Alabama at Birmingham, Birmingham, AL. Dr. Tollefsbol is a Professor of Biology and a Senior Scientist in the Center for Aging, Comprehensive Cancer Center, Nutrition Obesity Research Center, and the Comprehensive Diabetes Center at the University of Alabama at Birmingham (UAB). He is Director of the UAB Cell Senescence Culture Facility which he established in 1999 and a Steering Committee Member of the UAB Center for Aging. Dr. Tollefsbol trained as a Postdoctoral Fellow and Assistant Research Professor with members of the National Academy of Science at Duke University and the University of North Carolina. He earned doctorates in molecular biology and osteopathic medicine from the University of North Texas Health Sciences Center and his bachelor's degree in Biology from the University of Houston. He has received prior funding from the NIA, NCI, NHLBI, NIMH and other federal institutes as well as the Glenn Foundation for Medical Research, Susan G. Komen for the Cure, the American Federation for Aging Research (AFAR), and the American Institute for Cancer Research (AICR) among many other sources. The Glenn Foundation for Medical Research funding was unsolicited and was awarded to Dr. Tollefsbol for lifetime contributions to the field of aging. In 2006 Dr. Tollefsbol was selected and highlighted as part of the 25th anniversary of the AFAR for significant contributions to aging research. Dr. Tollefsbol's research interests have covered a wide range of topics such as aging, epigenetics, nutrition, cancer, telomerase, and caloric restriction. Work from his laboratory has been featured in Women's Health magazine, Shape magazine, and the AICR Newsletter and Dr. Tollefsbol has been a Scientist in the Spotlight in ScienceNow. Currently he serves as an Associate Editor for Frontiers in Epigenomics and is on the Editorial Boards of the international journals Open Longevity Science, Epigenetics of Diabetes and Obesity, Molecular Biotechnology and Clinical Epigenetics. He is also a contributing Editor of Lewin's GENES X classic textbook. Over 25 of the publications from Dr. Tollefsbol's laboratory have received national or international accolades such as best paper award, selection for press release by the journal editors and featured on the journal homepage. Dr. Tollefsbol has been invited to give presentations on his research in many countries including Germany, China, Italy, Switzerland, France and The Netherlands as well as at various leading institutions in the US such as Harvard Medical School, Tufts University and the University of California at San Francisco. His research has received considerable media attention both nationally and internationally through television, newspaper and radio venues and has been highlighted in eScience News and ScienceDaily. He has ten books which have been published or are in progress and a recent book on "Epigenetics of Aging” that Dr. Tollefsbol co-authored and edited was highlighted in Nature.
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