Oligomerization in Health and Disease, Vol 117. Progress in Molecular Biology and Translational Science

  • ID: 2496406
  • Book
  • 656 Pages
  • Elsevier Science and Technology
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This special volume of Progress in Molecular Biology and Translational Science focuses on oligomerization in health and disease.

- Contributions from leading authorities- Informs and updates on all the latest developments in the field

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Section I. Structural, Physico-Chemical, and Evolutionary Aspects of Protein Oligomerization

- Evolutionary, Physico-Chemical and Functional Mechanisms of Protein Homooligomerization

- Structural, Evolutionary and Assembly Principles of Protein Oligomerization

- Physico-Chemical Principles of Protein Aggregation

- Structural Aspects of Amyloid Formation

Section II. Oligomerization in Seven-Transmembrane Receptors

- Quaternary Structure Predictions and Structural Communication Features of GPCR Dimers

- Challenges in the Development of Heteromer-GPCR-Based Drugs

- Oligomerization of GPCRs in Health and Disease on "Di/Oligomerisation of GPCRS; Mechanisms and Functional Significance"

- G Protein-Coupled Receptor Heterocomplexes in Neuropsychiatric Disorders

- Disease-Specific Heteromerization of G Protein-Coupled Receptors that Target Drugs of Abuse

Section III. Oligomerization in Ion Channels

- Social Networking among Voltage-Gated Potassium Channels

- Oligomerization of the Mitochondrial Protein VDAC1: From Structure to Function and Cancer Therapy

- Consequences of Dimerization of the Voltage Gated Proton Channel

- Receptor Heteromeric Assembly, How it Works and Why it Matters
The Case of Ionotropic Glutamate Receptors

Section IV. Oligomerization in Enzymes

- The Structural Basis for the Allosteric Regulation of Ribonucleotide Reductase

- Oligomerization of Dynamin Superfamily Proteins in Health and Disease

- Multimerization of the Dnmt3a DNA Methyltransferase and its Functional Implications

- Oligomerization in Endoplasmic Reticulum Stress Signaling

Section V. Oligomerization in Regulatory Proteins

- Toll-IL-1-Receptor-Containing Adaptor Molecule-1 (TICAM-1), a Signaling Adaptor Linking Innate Immunity to Adaptive Immunity

- Assembly of Gamma-Tubulin Ring Complexes: Implications for Cell Biology and Disease

- Chemokine Oligomerization in Cell Signaling and Migration

- Oligomerization of Rab/Effector Complexes in the Regulation of Vesicle Trafficking
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