Liver Transplantation: Clinical Assessment and Management is the perfect tool for all gastroenterologists, hepatologists and transplant surgeons managing patients with liver disease awaiting and undergoing transplantation.
Led by James Neuberger, world experts in hepatology and transplantation provide a chronological, step–by–step approach to best clinical management and patient care.
Evidence–based throughout and with reference to the very latest practice guidelines from major societies such as EASL and AASLD, the book covers:
- When to refer a patient for liver transplantation
- Selection, assessment and management on the list
- Transplantation for acute liver failure
- Donation and allocation
- Care of the liver transplant recipient
80 high definition videos of transplant surgery allow you to watch the experts in action and provide an outstanding visual and teaching element. In addition, key points, potential pitfalls, management algorithms, and useful weblinks all help ensure rapid reference browsing.
If you′re managing patients requiring a liver transplant, this multimedia resource will save you time and effort by putting essential information within easy reach.
List of Contributors, ix
About the Companion Website, xvi
PART 1 When to Refer a Patient for Liver Transplantation
1 General Considerations, 3S. Tamir Rashid and Alexander E. Gimson
2 Prognostic Models in Liver Transplantation, 18James Neuberger
PART 2 Selection, Assessment and Management on the List
3 Assessing the Potential Transplant Recipient, 29Diarmaid D. Houlihan and Philip N. Newsome
4 Consent, 39Christopher J.E. Watson
5 Management on the Waiting List, 47Sumeet K. Asrani and Jayant A. Talwalkar
6 Specific Diseases, 60Ian A. Rowe and David J. Mutimer
7 Specific Issues of Selection including Non–Compliance, Futility, Nutritional and Social Issues, 73Ken Simpson
PART 3 Transplantation for Acute Liver Failure
8 Assessment of the Patient with Acute Liver Failure, 85Ashley Barnabas and John O Grady
9 Management of the Patient with Fulminant Hepatic Failure Awaiting Liver Transplantation, 93James Neuberger
PART 4 Donation and Allocation
10 Liver Donation, 103Gabriel C. Oniscu
11 Liver Allocation, 116Richard B. Freeman, Jr
12 Alternatives to Orthotopic Liver Replacement, 125James Neuberger
13 Surgical Aspects of Liver Transplantation, 129Thamara Perera and Simon Bramhall
PART 5 Care of the Liver Transplant Recipient
14 Introduction to Outcomes and Follow–Up, 147James Neuberger
15 The Immune System in Liver Transplantation: Rejection vs.Tolerance, 160Palak J. Trivedi and Nick D. Jones
16 Immunosuppression in Liver Transplantation, 184Aaron James Chan and John R. Lake
17 Microbiological Prophylaxis in Liver Transplantation, 197Matthew J. Armstrong and Philip N. Newsome
18 Managing the Liver Transplant Recipient with Abnormal Liver Blood Tests, 208Joanna A. Leithead and James Ferguson
19 Managing Rejection, 227Palak J. Trivedi and James Neuberger
20 Management of Renal Function, 248James Ferguson
21 Management of Post–Transplant Ascites, 256Chris Corbett and Philip N. Newsome
22 Cytomegalovirus and the Liver Transplant Recipient, 261James Ferguson
23 Immunisation and Liver Transplantation, 268James Neuberger
24 Contraception and Pregnancy, 274Carlo B. Ramirez, Cataldo Doria, Michael J. Moritz, John M. Davison andVincent T. Armenti
25 Common Drug Interactions, 283Amanda Smith
26 Management of Recurrent Disease, 290Michael R. Lucey
27 Managing Cardiovascular Risk in the Liver Transplant Recipient, 299Joanna K. Dowman and Philip N. Newsome
28 Bone Disease in Liver Transplantation, 309John Ayuk
29 Malignancy after Liver Transplantation, 316James Neuberger
30 Post–Transplant Lymphoproliferative Disorder, 325Joseph F. Buell, Nathan J. Shores, Thomas G. Gross, Jeremy R. Chapman and Angela C. Webster
Colour plate section facing p. 170
James Neuberger MD, Professor of Hepatology, Queen Elizabeth Hospital, Birmingham. Professor Neuberger is the Associate Medical Director at NHS Blood and Transplant, and Professor of Hepatology, Queen Elizabeth Hospital, Birmingham. He has worked in many aspects of liver disease and transplantation and been involved with UK Transplant (UKT) for over 10 years. He is also Editor–in–Chief of LWW′s Transplantation, the journal of the Transplantation Society, and on the board of several liver and transplant journals. He?has 295 articles listed on PubMed.
Dr James Ferguson MD, Consultant Hepatologist, Queen Elizabeth Hospital, Birmingham. Interests include: cardiovascular and renal dysfunction after liver transplantation and the complications of portal hypertension; portal hypertension, vascular disorders of the liver, alcoholic liver disease and adolescent transition.
Dr Philip Newsome, Senior Lecturer in Hepatology and Clinical Director of the Birmingham University Stem Cell Centre, Birmingham, UK. Dr Newsome has had many major research papers in scientific journals published as well as reviews and book chapters in the fields of virology, cancer and tumour immunology.?He has received major grants from NIHR, Wellcome Trust, UKSCF, BBSRC and the Medical Research Council.?He is an enthusiastic communicator on the theme of translational stem cell work and non–alcoholic fatty liver disease and gives frequent talks to various groups at both the local and national level.