Metabolic Syndrome and Neurological Disorders

  • ID: 2505290
  • Book
  • 576 Pages
  • John Wiley and Sons Ltd
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Metabolic syndrome is a recognized suite of biological risk factors that increase the likelihood of developing long–term health problems including a wide range of neurological disorders. Metabolic Syndrome and Neurological Disorders brings together information on the cluster of common pathologies which cause metabolic syndrome – obesity, insulin resistance, and hypertension – to provide a comprehensive and cutting edge exploration of the link between metabolic syndrome and neurological disorders.

Metabolic Syndrome and Neurological Disorders covers the molecular mechanisms thought to connect metabolic syndrome with neurological disorders ranging from stroke to neurodegenerative diseases. Chapters also look at how other factors such as oxidative stress and inflammation may play a role in disease development.

Grounded in a series of epidemiological studies of metabolic–cognitive syndrome, Metabolic Syndrome and Neurological Disorders is a valuable reference for researchers and clinicians in the field.

  • Comprehensive coverage of the molecular mechanisms behind the link between metabolic syndrome and stroke, Alzheimer disease, and depression
  • Timely investigation of a health issue which will be of increasing importance given the aging of the world′s population
  • Written by leaders in the field of metabolic syndrome
  • Unique, accessible exploration of a topic with relevance for a wide variety of disciplines, including neuroscientists, pharmacologists, and clinicians
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Foreword Mark P. Mattson xi

Preface Tahira Farooqui and Akhlaq A. Farooqui xiii

Acknowledgments Tahira Farooqui and Akhlaq A. Farooqui xv

Contributors xvii

1 Insulin Resistance and Metabolic Failure Underlie Alzheimer Disease 1Suzanne M. de la Monte and Ming Tong

2 Insulin Receptor and the Pathophysiology of Alzheimer Disease 31Johanna Zemva and Markus Schubert

3 Contribution of Insulin Resistance in Pathogenesis of Alzheimer Disease 51Adnan Erol

4 Insulin Leptin Signaling in the Brain 75Vicente Barrios, Emma Burgos–Ramos, and Jes´us Argente

5 The Janus Face of Insulin in Brain 85Ana Duarte, Emanuel Candeias, S´onia C. Correia, Renato X. Santos, Cristina Carvalho, Susana Cardoso, Ana I. Pl´acido, Maria S. Santos, Catarina R. Oliveira, and Paula I. Moreira

6 Modulation of Cognition by Insulin and Aging: Implications for Alzheimer Disease 115Maite Solas and Maria J. Ram´ýrez

7 Contribution of Phospholipid, Sphingolipids, and Cholesterol–Derived Lipid Mediators in the Pathogenesis of Metabolic Syndrome and Neurological Disorders 137Akhlaq A. Farooqui and Tahira Farooqui

8 Lipids, Cholesterol, and Oxidized Cholesterol in Alzheimer Amyloid Beta–Mediated
Neurotoxicity 163Mun delanji C. Vestergaard, Masamune Morita, Tsutomu Hamada, and Masahiro Takagi

9 Of Sound Mind and Body: Dietary Lifestyles, Promotion of Healthy Brain Aging, and Prevention of Dementia in Healthy Individuals 179Giulio Maria Pasinetti, Amanda Bilski, Lap Ho, Jun Wang, Mario Ferruzzi, Masahito Yamada, Kenjiro Ono, and Salvatore Mannino

10 Metabolic Syndrome as an Independent Risk Factor of Silent Brain Infarction 191Jae–Sung Lim and Hyung–Min Kwon

11 Neurochemical Linkage Among Metabolic Syndrome, Alzheimer Disease, and Depression 197Undurti N. Das

12 Alterations in the Endocannabinoid System as a Link Between Unbalanced Energy Homeostasis, Neuroinflammation, and Neurological and Neuropsychiatric Disorders 219Tiziana Bisogno and Vincenzo Di Marzo

13 Metabolic Syndrome, Alzheimer Disease, Schizophrenia, and Depression: Role for Leptin, Melatonin, Kynurenine Pathways, and Neuropeptides 235George Anderson and Michael Maes

14 Binge Eating and Metabolic Syndrome 249Ignacio J´auregui–Lobera

15 Phytochemical Principles in the Traditional Indian System of Medicine Used for the Management of Metabolic Syndrome 261Syed Ibrahim Rizvi and Neetu Mishra

16 Oxidative Stress and Obesity: Their Impact on Metabolic Syndrome 275Morihiro Matsuda and Iichiro Shimomura

17 The Relationship Among Obesity, Inflammation, and Insulin Resistance 283Jean–Philippe Bastard and Bruno F`eve

18 Involvement of Adipocytokines in Pathogenesis of Insulin Resistance, Obesity, and Metabolic Syndrome 297Hardik Gandhi and Ramachandran Balaraman

19 Obesity, Inflammation, and Vascular Disease: Novel Insight in the Role of Adipose Tissue 311Paolo Calabro, Enrica Golia, Valeria Maddaloni, Giuseppe Limongelli, Brunella Ziello, Fabio Fimiani, Ilaria Jane Romano, Mario Crisci, Maria Giovanna Russo, Edward T.H. Yeh, and Raffaele Calabro

20 Is Diabetes a Risk Factor for Parkinson Disease? 327Akhlaq A. Farooqui and Tahira Farooqui

21 Role of Iron in the Pathogenesis of Diabetes and Metabolic Syndrome 335Lu Cai

22 Contributions of AMP Kinase to the Pathogenesis of Type 2 Diabetes and Neurodegenerative Diseases 363Mohamed Kodiha, Hicham Mahboubi, and Ursula Stochaj

23 A— Deposition, Insulin Signaling, and Tau Phosphorylation in Animal Models of Alzheimer Disease and Diabetes 383Naoyuki Sato and Ryuichi Morishita

24 In Vivo Evidence of the Convergence of Type 2 Diabetes and Alzheimer Disease 395Sun Ah Park

25 Metabolic Syndrome and its Impact on Cardiovascular Disease 409John A. Larry

26 Contribution of Inflammation, Adiponectin, and Obesity in Cardiovascular Diseases 423Harald Mangge and Gunter Almer

27 Brain and Cardiovascular Diseases: Molecular Aspects 439Ewa Szczepanska–Sadowska

28 Molecular Aspects of Dietary Exercise Regimen for the Prevention of Metabolic Syndrome 461Wataru Aoi

29 Ghrelin, Lipid Metabolism, and Metabolic Syndrome 475Pablo B. Mart´ýnez de Morentin, Sulay Tovar, Rub´en Nogueiras, Miguel L´opez, and Carlos Di´eguez

30 Leptin and Cognitive Function 485Jenni Harvey

31 Fructose, Sugar Consumption, and Metabolic Diseases 501Virgile Lecoultre and Luc Tappy

32 Inflammation–Mediated Cognitive and Emotional Alterations in Experimental Models of Metabolic Syndrome 515Nathalie Castanon and Sophie Lay´e33 Summary and Perspective 529Tahira Farooqui and Akhlaq A. Farooqui

Index 539

Color plate section is located between pages 196 and 197.

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Akhlaq A. Farooqui
Tahira Farooqui
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