In this second edition of Post-Genomic Cardiology, developing and new technologies such as translational genomics, next generation sequencing (NGS), bioinformatics, and systems biology in molecular cardiology are assessed in light of their therapeutic potential. As new methods of mutation screening emerge, both for the genome and for the "epigenome, comprehensive understanding of the many mutations that underlie cardiovascular diseases and adverse drug reactions is within our reach.
This book, written by respected cardiologist José Marín-García, features discussion on the Hap-Map: the largest international effort to date aiming to define the differences between our individual genomes. This unique reference further reviews and investigates genome sequences from our evolutionary relatives that could help us decipher the signals of genes, and offers a comprehensive and critical evaluation of regulatory elements from the complicated network of the background DNA.
- Offers updated discussion of cutting-edge molecular techniques including new genomic sequencing / NGS / Hap-Map / bioinformatics / systems biology approaches
- Analyzes mitochondria dynamics and their role in cardiac dysfunction, up-to-date analysis of cardio-protection, and cardio-metabolic syndrome
- Presents recent translational studies, gene therapy, transplantation of stem cells, and pharmacological treatments in CVDs
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Section I: Post-Genomic Cardiology 1. Introduction to the Molecular Biology of the Cell 2. Methodologies in the Era of Cardiovascular "Omics 3. Post-Genomics Cardiovascular Signaling Pathways
Section II: Pediatric Cardiology in the Post-Genomic Era 4. Molecular Determinants of Cardiac Development 5. Molecular Determinants of Congenital Heart Disease
Section III: Post-Genomic Assessment of Coronary Artery Disease, Angiogenesis, and Hypertension 6. Molecular Determinants of Atherosclerosis 7. Molecular Genetics of Coronary Artery Disease and Myocardial Infarction 8. Cellular and Molecular Aspects of Cardioprotection 9. Molecular Determinants of Cardiac Neovascularization 10. Post-Genomics Appraisal of Systemic and Pulmonary Hypertension
Section IV: Post-Genomic Analysis of the Myocardium 11. Post-Genomic Appraisal of Myocarditis 12. Cardiomyopathies: A Comparative Analysis of Phenotypes and Genotypes
Section V: Heart Failure, Cell Death, and Mitochondria Dynamics 13. Gene Profiling, Energy Metabolism, and Remodeling of the Failing Heart 14. Oxidative Stress and Cell Death in Cardiovascular Disease: A Post-Genomic Appraisal 15. The Emerging Role of Mitochondrial Dynamics in Cardiovascular Disease
Section VI: Molecular and Genetic Analysis of Metabolic Disorders 16. Post-Genomic Analysis of Fatty Acid and Glucose Metabolism in Cardiovascular Disease
Section VII: Molecular Genetics of Dysrhythmias 17. Post-Genomic Analysis of Dysrhythmias and Sudden Death
Section VIII: Genes, Gender, and Epigenetics 18. Gender and Cardiovascular Disease in the Post-Genomic Era
Section IX: Aging and the Cardiovascular System 19. The Aging Heart: A Post-Genomic Appraisal 20. Targeted Strategies to Fight Cardiac Aging 21. Aging and the Cardiovascular System: The Road Ahead
Section X: Genetics, Epigenetics, and New Approaches to Treatment 22. Epigenetics and Cardiovascular Disease 23. Gene- and Cell-Based Therapy for Cardiovascular Disease
Section XI: Looking to the Future 24. The Path to Personalized Cardiovascular Medicine
Dr.José Marín-García, highly respected cardiologist, is the current Director of Molecular Cardiology and Neuromuscular Institute in Highland Park, NJ. He has 189 listed publications and an H-index of 30. He has written and edited Mitochondria and the heart (2005), Aging and the Heart (2008), Signaling in the Heart (2008). Heart Failure (2010), Post-Genomic Cardiology (2007), and Mitochondria and Their Role in Cardiovascular Disease (2012).