Microfluidics and Nanofluidics. Theory and Selected Applications

  • ID: 2542517
  • Book
  • 456 Pages
  • John Wiley and Sons Ltd
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A one–stop resource for understanding all aspects of microfluidics and nanofluidics

An increasingly influential topic in nanoscience and technology, fluidics is often necessarily employed in handling fluid–particle flow, material processing, and signal transferring in devices ranging from the macro–scale to the nano–scale. Microfluidics and Nanofluidics reviews key concepts in fluid mechanics and heat transfer, microfluidics, nanofluidics, and applicable math modeling and computer simulation.

With attention to the fundamentals as well as advanced applications of fluidics, this book imparts a solid knowledge base and develops skills for future problem–solving and system analysis. Fluidics expert and author Clement Kleinstreuer offers a problem/solution format that addresses system sketches, assumptions and postulates, as well as concepts and approaches before launching into analytical solutions and their extensions. Engineers, physicists and mathematicians will be comfortable with the author′s split approach to introducing new material, explaining concepts, presenting flow visualizations, and outlining problem–solving techniques.

Designed to help advanced undergraduate and first–year graduate students solve fluidics problems independently, provide physical insight, and suggest system design improvements, Microfluidics and Nanofluidics includes:

  • Eight comprehensive chapters on classical fluidics theory with applications in macrofluidics, microfluidics theory, applications in microfluidics, nanofluidics theory, applications in nanofluidics, modeling and simulation aspects, and computational case studies
  • Step–by–step example problems and homework assignments for each chapter
  • Solutions manual available to qualified instructors
  • Exposure to the firsthand research and insights of a well–known author who has published extensively on advanced mechanical and biomedical engineering topics

This is a vital resource for upper–level engineering students who want to expand their potential career opportunities and familiarize themselves with an increasingly important field.

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Preface xv

Part A: A REVIEW OF ESSENTIALS IN MACROFLUIDICS 1

CHAPTER 1 Theory 3

1.1 Introduction and Overview 3

1.2 Definitions and Concepts 8

1.3 Conservation Laws 23

1.4 Homework Assignments 74

CHAPTER 2 Applications 79

2.1 Internal Fluid Flow 79

2.2 Porous Medium Flow 108

2.3 Mixture Flows 118

2.4 Heat Transfer 151

2.5 Convection–Diffusion Mass Transfer 162

2.6 Homework Assignments 176

References (Part A) 186

Part B: MICROFLUIDICS 189

CHAPTER 3 Microchannel Flow Theory 191

3.1 Introduction 191

3.2 Basic Concepts and Limitations 195

3.3 Homework Assignments 251

CHAPTER 4 Applications in Microfluidics 255

4.1 Introduction 255

4.2 Micropumps and Microchannel Flow 256

4.3 Micromixing 280

4.4 Laboratory–on–a–Chip Devices 284

4.5 Homework Assignments and Course Projects 288

References (Part B) 290

Part C: NANOFLUIDICS 293

CHAPTER 5 Fluid Flow and Nanofluid Flow in Nanoconduits 295

5.1 Introduction 295

5.2 Liquid Flow in Nanoconduits 303

5.3 Rarefied Gas Flow in Nanochannels 328

5.4 Homework Assignments and Course Projects 335

CHAPTER 6 Applications in Nanofluidics 339

6.1 Introduction 339

6.2 Nanoparticle Fabrication 340

6.3 Forced Convection Cooling with Nanofluids 342

6.4 Nanodrug Delivery 351

6.5 Homework Assignments and Course Projects 356

References (Part C) 358

Part D: COMPUTER SIMULATIONS OF FLUID–PARTICLE MIXTURE FLOWS 361

CHAPTER 7 Modeling and Simulation Aspects 363

7.1 Introduction 363

7.2 Mathematical Modeling 365

7.3 Computer Simulation 367

CHAPTER 8 Computational Case Studies 375

8.1 Introduction 375

8.2 Model Validation and Physical Insight 376

8.3 Solid Tumor Targeting with Microspheres 386

8.4 Homework Assignments and Course Projects 390

References (Part D) 393

APPENDICES 395

APPENDIX A 397

A.1 Tensor Calculus 397

A.2 Differentiation 403

A.3 Integral Transformations 407

A.4 Ordinary Differential Equations 411

A.5 Transport Equations (Continuity, Momentum, and Heat Transfer) 415

APPENDIX B 420

B.1 Conversion Factors 420

B.2 Properties 423

B.3 Drag Coefficient: (A) Smooth Sphere and (B) An Infinite Cylinder as a Function of Reynolds Number 427

B.4 Moody Chart 428

References (Appendices) 429

INDEX 431

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Clement Kleinstreuer, PhD, is a professor of mechanical and biomedical engineering at North Carolina State University. His current research pertains to computational fluid–particle dynamics with applications of micro/nanofluidics to medical device development.

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