A classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a secondhand analysis, we are given stories that vividly demonstrate the power of the human endeavor known as organic synthesis and the creativity and tenacity of its practitioners. Firsthand accounts of each project tell of the excitement of conception, the frustration of failure and the joy experienced when either rational thought or good fortune gives rise to the successful completion of a project. This book series shows how synthesis is really done, and we are educated, challenged and inspired by these accounts, which portray the idea that triumphs do not come without challenges. We also learn that we can meet challenges to further advance the science and art of organic synthesis, driving it forward to meet the demands of society, in discovering new reactions, creating new designs and building molecules with atom and step economies that provide solutions through function to create a better world.
- Presents state-of-the-art developments in organic synthesis
- Provides insight and offers new perspective to problem-solving
- Written by leading experts in the field
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Foreword, Albert Eschenmoser Preface, Michael Harmata Total Synthesis of Strychnos Alkaloids, Rodrigo B. Andrade Total Synthesis of Celogentin C: Development of an Unusual Indole-Imidazole Oxidative Coupling, Steven L. Castle A Carbonyl-Enabled Synthesis of the Guaiane Sesquiterpene Englerin A, William J. Chain Synthesis of the Sesquiterpenes Anislactone A and Merrilactone A, Michael Greaney Symmetry-Driven Total Synthesis of Merrilactone A and Resolvin E2, Masayuki Inoue Studies on bis
1, 2, 4
triazine ligands: Privileged Ligands for Separating Actinides from Lanthanides, Frank Lewis, Laurence M. Harwood Synthesis of (+) Hamigeran B using an Intramolecular Alkynylogous Mukaiyama Aldol Reaction, Michel Miesch Exploring Prins Strategies for the Synthesis of Okilactomycin, Karl Scheidt Taking Risks in Complex Synthesis Design, Erik J. Sorensen Stereoselective Addition of Halogen to Conjugated Enynes and Its Application in the Total Synthesis of (-)-Kumausallene, Weiping Tang Total Synthesis of Aspergillide C, Stephen P. Waters Index
Professor Michael Harmata graduated from the University of Illinois-Chicago with honors and highest distinction in chemistry.
In 1980, he began graduate studies in chemistry at the University of Illinois-Champaign/Urbana where he was awarded a University Teaching Fellowship. He worked with Professor Scott E. Denmark on the invention of the carbanion-accelerated Claisen rearrangement. In his second year of study, he was awarded an Eastman Kodak Research Fellowship.
Upon graduation in 1985, he was awarded an NIH postdoctoral fellowship which he used to study with Professor Paul A. Wender at Stanford University, where he worked on the synthesis of the neocarzinostatin chromophore.
In 1986, Prof. Harmata began his independent career at the University of Missouri-Columbia. He became an Associate Professor in 1992 and a full professor in 1998. In 2000, he was named the Norman Rabjohn Distinguished Professor of Chemistry in recognition of his achievements in research and teaching. In 1998, he received a research fellowship from the Alexander von Humboldt Foundation and stayed for a year at the University of Göttingen where he was affiliated with the groups of Professors Reinhard Brückner and Lutz. F. Tietze. In 2000, he served as chair of the Gordon conference on Organic Reactions and Processes. In 2010, he was named the first Justus Liebig Professor of Chemistry at the Justus Liebig Üniversität in Giessen, Germany. In 2011, he was a JSPS fellow. He has been a visiting professor in Giessen and Strasbourg and has delivered over 180 invited lectures in the United States and Europe. He is a member of the American Chemical Society, Gesellschaft Deutscher Chemiker, International Society of Heterocyclic Chemistry, and the Alexander von Humboldt Association of America.