This book provides an overview of skeletal biology from the molecular level to the organ level, including cellular control, interaction and response; adaptive responses to various external stimuli; the interaction of the skeletal system with other metabolic processes in the body; and the effect of various disease processes on the skeleton. The book also includes chapters that address how the skeleton can be evaluated through the use of various imaging technologies, biomechanical testing, histomorphometric analysis, and the use of genetically modified animal models.
- Presents an in-depth overview of skeletal biology from the molecular to the organ level
- Offers "refresher" level content for clinicians or researchers outside their areas of expertise
- Boasts editors and many chapter authors from Indiana and Purdue Universities, two of the broadest and deepest programs in skeletal biology in the US; other chapter authors include clinician scientists from pharmaceutical companies that apply the basics of bone biology
Chapter 1: Bone morphology and organization
Chapter 2: Bone cells
Chapter 3: Local regulation of bone cell function
Chapter 4: Bone modeling and remodeling
Assessment of Bone Structure and Function
Chapter 5: Skeletal imaging
Chapter 6: Skeletal hard tissue biomechanics
Chapter 7: Techniques in histomorphometry
Chapter 8: Skeletal genetics
Chapter 9: Mechanical adaptation
Chapter 10: Fracture healing
Chapter 11: Craniofacial biology, orthodontics, and implants
Hormonal and Metabolic Effects on Bone
Chapter 12: Skeletal growth and development
Chapter 13: Calcium and phosphate: Hormonal regulation and metabolism
Chapter 14: Nutrition
Chapter 15: Hormonal effects on bone cells
Skeletal disease and treatment
Chapter 16: Metabolic bone diseases
Chapter 17: Pharmaceutical treatments of osteoporosis
David B. Burr is a University Distinguished Professor of Anatomy and Cell Biology at Indiana University School of Medicine, and Professor of Biomedical Engineering at IUPUI. He joined the Indiana University School of Medicine faculty in 1990 as Chair of the Department of Anatomy (1990-2010), following faculty positions at the University of Kansas and West Virginia University Medical Schools. He served as President of the American Association of Anatomists (2007-2009) and the Orthopaedic Research Society, and is the Director of the IBMS Sun Valley Workshop on Musculoskeletal Biology. He is a fellow of the American Association of Anatomists, and serves as Editor-in-Chief for Current Osteoporosis Reports, Associate Editor for Bone and the J of Musculoskeletal and Neuronal Interactions. He is the author of more than 230 research articles in the peer- reviewed literature, 48 book chapters and reviews, and four books on the structure, function and mechanics of bone.
Allen, Matthew R.
Matthew R. Allen is an Associate Professor of Anatomy and Cell Biology at Indiana University School of Medicine. His research career, and interest in bone biology, began at Alma College during a summer research fellowship and continued during his years as a PhD student at Texas A&M (in Kinesiology) and post-doctoral fellow at IU School of Medicine. His research focuses on understanding how interventions can be maximized to strengthen the skeleton and his teaching duties include Medical Histology (to first year medical students) and Basic Bone Biology (to graduate students). He serves on the Editorial Board for the Journal of Bone and Mineral Research, BONE, and BoneKEY, and as an Associate Editor for Clinical Reviews in Bone and Mineral Metabolism. He has authored more than 70 research articles and 18 book chapters and reviews.