Protein Phosphorylation in Parasites. Novel Targets for Antiparasitic Intervention. Drug Discovery in Infectious Diseases

  • ID: 2586490
  • Book
  • 456 Pages
  • John Wiley and Sons Ltd
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This is the first book to collect and summarize in one publication the efforts to target kinases or phosphatases for drug development against parasite infections. The editors and contributors comprise the Who s Who in the field, and they are comprehensive in covering every aspect of the topic, from basic research findings to translational approaches in drug development.

The result will be welcomed by everyone in academia and industry participating in the global effort to finally combat the major diseases caused by eukaryotic parasites. This is volume one of a two–volume treatise, the second being exclusively dedicated to efforts to combat malaria using the same approach.

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Foreword (D. Leroy)

Preface

PART I BIOINFORMATICS

Computational Analysis of Apicomplexan Kinomes (E. Talevich, N. Kannan, D. M. Saavedra)

Phosphatomes of Unicellular Eukaryotic Parasites (A. V. Andreeva, M. A. Kutuzov)

PART II FUNTIONAL ANALYSIS OF PARASITE KINOMES AND PHOSPHATOMES

Trypanosomatid Phosphoproteomics (M. D. Urbaniak)

Trypanosomatid Cell Division Kinases (C. Benz, E. Thomas, T. C. Hammarton)

Kinetoplastid AGC Kinases (S. Bachmaier, M. Boshart,)

Plasmodium eIF2a Kinases (D. E. Goldberg, M. Zhang, V. Nussenzweig)

Protein Kinases of the Parasitic Protist Entamoeba Histolytica (Somlata, M. Babuta, S. Bhattacharya, A. Bhattacharya)

Protein Phosphatases in Trypanosome Growth and Development (B. Szoor, K. R. Matthews)

PART III ROLE OF HOST CELL KINOMES AND PHOSPATOMES IN PARASITIC INFECTIONS

Hijacking of Host Cell Signaling by Theileria (K. Woods, C. von Schubert, D. Dobbelaere)

The Role of Host and Parasite Encoded Kinases in Toxoplasma Host Interactions (I. J. Blader, G. Arrizabalaga, W. J. Sullivan Jr.)

Macrophage Kinases in Leishmaniasis (M. K. Padwal, U. Sarma, R. Sudan, B. Saha)

PART IV DRUG DISCOVERY

Selective Inhibition of Parasite Protein Kinases (J. D. Artz, A. K.Wernimont, L. Y. Lin, M. Amani, M. Neculai, T. Hills, R. Hui)

Kinase Inhibitors among Hits from Malaria Cellular Screens (J. R. Brown, D. Drewry, F.–J. Gamo, J. F. Garcia–Bustos)

Calcium Dependent Protein Kinases of Apicomplexan Parasites as Drug Targets (K. K. Ojo, E. A. Merritt, D. J. Maly, W. C. Van Voorhis)

Protein Kinases as Suitable Targets for Fighting Eimeria spp. (R. J. Marhöfer, J. C. Mottram, P. M. Selzer)

Receptor Tyrosine Kinase Signalling and Drug Targeting in Schistosomes (C. Dissous, M. Vanderstraete, S. Beckmann, N. Gouignard, S. Leutner, C. Buro, C. G. Grevelding)

Protein Kinases as Drug Targets in the Treatment of Alveolar Echinococcosis (K. Brehm)

Collaborative Drug Design of Plasmodium Kinase Inhibitors (B. Hardy, R. Affentranger, A. Contini, H. Gutierrez de Teran, J. Spitzner, R. Papoian, W. Seibel, S. Nelson, J. Wiseman, S. D. Bryant, I. Lucet, C. Doerig)

Index
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Christian Doerig
Gerald Spaeth
Martin Wiese
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