This is the first book to collect and summarize in one publication the efforts to target kinases or phosphatases for drug development against parasite infections. The editors and contributors comprise the Who s Who in the field, and they are comprehensive in covering every aspect of the topic, from basic research findings to translational approaches in drug development.
The result will be welcomed by everyone in academia and industry participating in the global effort to finally combat the major diseases caused by eukaryotic parasites. This is volume one of a two–volume treatise, the second being exclusively dedicated to efforts to combat malaria using the same approach.
PART I BIOINFORMATICS
Computational Analysis of Apicomplexan Kinomes (E. Talevich, N. Kannan, D. M. Saavedra)
Phosphatomes of Unicellular Eukaryotic Parasites (A. V. Andreeva, M. A. Kutuzov)
PART II FUNTIONAL ANALYSIS OF PARASITE KINOMES AND PHOSPHATOMES
Trypanosomatid Phosphoproteomics (M. D. Urbaniak)
Trypanosomatid Cell Division Kinases (C. Benz, E. Thomas, T. C. Hammarton)
Kinetoplastid AGC Kinases (S. Bachmaier, M. Boshart,)
Plasmodium eIF2a Kinases (D. E. Goldberg, M. Zhang, V. Nussenzweig)
Protein Kinases of the Parasitic Protist Entamoeba Histolytica (Somlata, M. Babuta, S. Bhattacharya, A. Bhattacharya)
Protein Phosphatases in Trypanosome Growth and Development (B. Szoor, K. R. Matthews)
PART III ROLE OF HOST CELL KINOMES AND PHOSPATOMES IN PARASITIC INFECTIONS
Hijacking of Host Cell Signaling by Theileria (K. Woods, C. von Schubert, D. Dobbelaere)
The Role of Host and Parasite Encoded Kinases in Toxoplasma Host Interactions (I. J. Blader, G. Arrizabalaga, W. J. Sullivan Jr.)
Macrophage Kinases in Leishmaniasis (M. K. Padwal, U. Sarma, R. Sudan, B. Saha)
PART IV DRUG DISCOVERY
Selective Inhibition of Parasite Protein Kinases (J. D. Artz, A. K.Wernimont, L. Y. Lin, M. Amani, M. Neculai, T. Hills, R. Hui)
Kinase Inhibitors among Hits from Malaria Cellular Screens (J. R. Brown, D. Drewry, F.–J. Gamo, J. F. Garcia–Bustos)
Calcium Dependent Protein Kinases of Apicomplexan Parasites as Drug Targets (K. K. Ojo, E. A. Merritt, D. J. Maly, W. C. Van Voorhis)
Protein Kinases as Suitable Targets for Fighting Eimeria spp. (R. J. Marhöfer, J. C. Mottram, P. M. Selzer)
Receptor Tyrosine Kinase Signalling and Drug Targeting in Schistosomes (C. Dissous, M. Vanderstraete, S. Beckmann, N. Gouignard, S. Leutner, C. Buro, C. G. Grevelding)
Protein Kinases as Drug Targets in the Treatment of Alveolar Echinococcosis (K. Brehm)
Collaborative Drug Design of Plasmodium Kinase Inhibitors (B. Hardy, R. Affentranger, A. Contini, H. Gutierrez de Teran, J. Spitzner, R. Papoian, W. Seibel, S. Nelson, J. Wiseman, S. D. Bryant, I. Lucet, C. Doerig)
Christian Doerig obtained his PhD in molecular virology at the Swiss Institute for Experimental Cancer Research in Lausanne, Switzerland. After a post–doctoral training on herpes simplex virus in the USA, he turned his attention to malaria and pioneered the study of protein phosphorylation in Plasmodium. He is Directeur de Recherches at the French biomedical research agency Inserm and established the first Inserm units in the UK at the Wellcome Trust Centre for Molecular Parasitology, University of Glasgow and subsequently in Switzerland at the Inserm–EPFL joint laboratory, Ecole Polytechnique Fédérale de Lausanne. In 2011, he joined Monash University in Melbourne, AUS, as Head of the Department of Microbiology, focusing on kinomics, cell proliferation, and development of malaria parasites.
Gerald Späth studied biology at the Johannes Gutenberg University, Mainz, Germany. He carried out his PhD thesis at the Institut Pasteur and joined Washington University Medical School in Saint Louis, USA, to carry out his post–doctoral training on the analysis of Leishmania virulence genes. He obtained his first faculty appointment in 2001 at the NYU Medical School, New York,USA, and created his research unit in 2005 at the Institut Pasteur in Paris, France, where he applies phospho–proteomics approaches to define Leishmania–specific signaling pathways as novel drug targets. Gerald Späth is currently Associate Professor at the Institut Pasteur, where he coordinates the Leishmania research of the Institut Pasteur International Network.
Martin Wiese studied biology, microbiology, biochemistry and parasitology at the Universities of Karlsruhe and Tübingen, Germany. He obtained his PhD for his studies on Leishmania at the Max–Planck Institute for Biology, laying the foundation for his studies on mitogen–activated protein kinases of Leishmania. In 2001 he became independent research group leader at the
Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany. Since 2007 he is a John Anderson Research Senior Lecturer at the University of Strathclyde, Glasgow, UK. His research is focused on parasite protein kinases as drug targets and the identification of signaling pathways in Leishmania using phosphoproteomics, molecular parasitology and protein biochemistry.
Paul M. Selzer studied biology, parasitology, and biochemistry at the University of Tübingen, Germany, where he also received his PhD in biochemistry. He spent three years at the Molecular Design Institute and the Parasitology and Tropical Disease Research Laboratory at the University of California, San Francisco. During his career he has worked as a researcher and scientific manager for several pharmaceutical companies, and is currently Director, Molecular Discovery Sciences
at MSD Animal Health Innovation GmbH, Germany. He is also a visiting professor and teacher at the Biochemistry Institute of the University of Tübingen, and an honorary professor of the Department of Infection, Immunity, and Inflammation at the University of Glasgow, UK.