Since publication of the 4th Edition of The Autoimmune Diseases in 2006, the understanding of the immune mechanisms underlying autoimmunity and autoimmune disease has significantly deepened and broadened. This fully revised 5th Edition incorporates new material and combines common themes underlying inductive and effector mechanisms and therapies that relate generally to the autoimmune disorders. It discusses the biological basis of disease at genetic, molecular, cellular, and epidemiologic levels and includes expanded coverage of autoinflammatory disease and autoimmune responses to tumors.
Part I. Immunologic Basis of Autoimmunity
Part II A.Immune Cells and Immune Responses
Part II B. Non-Antigen-Specific Recognition
Part III. Initiation of Autoimmunity
Part IV. Facilitation of Autoimmunity
Part V. Experimental Models of Autoimmunity
Part VI. Multisystem Autoimmune Diseases
Part VII. Endocrine System
Part VIII. Blood Disorders
Part IX. Central and Peripheral Nervous System
Part X. Gastrointestinal System
Part XI. Skin Diseases
Part XII. Nephropathies and Reproductive System
Part XIII. Cardiovascular System and Lungs
Part XIV. Unclassified Expressions of Autoimmunity
Part XV. Diagnosis, Prevention and Therapy
Noel Rose was born in Stamford, Connecticut. He attended Yale University for his undergraduate education followed by the University of Pennsylvania for a Ph.D. and State University of New York at Buffalo for an MD. He was a member of the faculty of the State University of New York at Buffalo School of Medicine for a period of 20 years, rising through the ranks to become a professor of Microbiology and Medicine, Director of Clinical Laboratories and Director of the Center for Immunology. He then spent ten years at Wayne State University School of Medicine where he chaired the Department of Immunology and Microbiology. In 1981, he joined the faculty of Johns Hopkins University as chairman of the Department of Immunology and Infectious Diseases. He presently holds professorial appointments in the Departments of Pathology, Molecular Microbiology and Immunology, Medicine and Environmental Health Sciences at The Johns Hopkins University and directs the Center for Autoimmune Disease Research. Dr. Rose's original investigations on the autoimmune basis of thyroid disease in 1956 opened the present era of research on autoimmunity. He has since investigated many areas of autoimmunity and related issues in clinical and basic immunology. Dr. Rose is the author or co-author of over 800 scientific papers and editor or co-editor of 24 books. He has received numerous honors, including two honorary doctoral degrees, election to fellowship in national or international societies, service in national and international organizations and editorial boards of leading journals.
Ian R. Mackay Professor, Monash University, Clayton, Victoria, Australia.
In the 1950s and 1960s Professor Mackay led the field of research into autoimmune diseases, coining the term 'autoimmunity'.
In 1963, he and Sir Macfarlane Burnet published a definitive monograph on the subject, firmly placing autoimmunity on the research map. Professor Mackay defined major autoimmune diseases of the liver and devised a life-saving protocol for autoimmune hepatitis that remains standard today. He also advanced knowledge on many other expressions of autoimmunity.